Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats

Clerodendrum trichotomum has been reported to possess beneficial properties for human health, but its effects on metabolic syndrome have not been reported. In this study, we investigated the effect of C. trichotomum leaf extract (CT) on the metabolic derangements induced by a high-fructose (HF) diet...

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Autores principales:	Mi Gyeong Jang, Jung Min Oh, Hee Chul Ko, Jae-Won Kim, Songyee Baek, Yeong Jun Jin, Sung-Pyo Hur, Se-Jae Kim
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	clerodendrum trichotomum dyslipidemia insulin resistance high fructose diet metabolic disorders Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9e22db6b0d1648f69a9daf0ce438c074
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id	oai:doaj.org-article:9e22db6b0d1648f69a9daf0ce438c074
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spelling	oai:doaj.org-article:9e22db6b0d1648f69a9daf0ce438c0742021-11-26T11:19:48ZClerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats1976-83542151-248510.1080/19768354.2021.2004221https://doaj.org/article/9e22db6b0d1648f69a9daf0ce438c0742021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/19768354.2021.2004221https://doaj.org/toc/1976-8354https://doaj.org/toc/2151-2485Clerodendrum trichotomum has been reported to possess beneficial properties for human health, but its effects on metabolic syndrome have not been reported. In this study, we investigated the effect of C. trichotomum leaf extract (CT) on the metabolic derangements induced by a high-fructose (HF) diet. Sprague–Dawley rats were fed with a 46% carbohydrate diet (HC group), 60% high-fructose diet (HF group), or HF diet supplemented with CT (500 mg/kg of body weight/day, CT group) via drinking water for 16 weeks. Results showed that CT alleviated HF diet-induced insulin resistance, dyslipidemia, and hepatic steatosis In liver tissues, CT affected the signaling pathways of AMP-activated protein kinase, peroxisome proliferator-activated receptor α (PPARα), and sterol regulatory element binding protein 1. CT enriched the genes that were mainly involved in cytokine-cytokine receptor interaction, PPAR, PI3K-Akt signaling pathways, and fatty acid metabolism pathway. These results suggest that CT is a promising therapeutic against metabolic disorders.Mi Gyeong JangJung Min OhHee Chul KoJae-Won KimSongyee BaekYeong Jun JinSung-Pyo HurSe-Jae KimTaylor & Francis Grouparticleclerodendrum trichotomumdyslipidemiainsulin resistancehigh fructose dietmetabolic disordersMedicine (General)R5-920Biology (General)QH301-705.5ENAnimal Cells and Systems, Vol 0, Iss 0, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clerodendrum trichotomum dyslipidemia insulin resistance high fructose diet metabolic disorders Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	clerodendrum trichotomum dyslipidemia insulin resistance high fructose diet metabolic disorders Medicine (General) R5-920 Biology (General) QH301-705.5 Mi Gyeong Jang Jung Min Oh Hee Chul Ko Jae-Won Kim Songyee Baek Yeong Jun Jin Sung-Pyo Hur Se-Jae Kim Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats
description	Clerodendrum trichotomum has been reported to possess beneficial properties for human health, but its effects on metabolic syndrome have not been reported. In this study, we investigated the effect of C. trichotomum leaf extract (CT) on the metabolic derangements induced by a high-fructose (HF) diet. Sprague–Dawley rats were fed with a 46% carbohydrate diet (HC group), 60% high-fructose diet (HF group), or HF diet supplemented with CT (500 mg/kg of body weight/day, CT group) via drinking water for 16 weeks. Results showed that CT alleviated HF diet-induced insulin resistance, dyslipidemia, and hepatic steatosis In liver tissues, CT affected the signaling pathways of AMP-activated protein kinase, peroxisome proliferator-activated receptor α (PPARα), and sterol regulatory element binding protein 1. CT enriched the genes that were mainly involved in cytokine-cytokine receptor interaction, PPAR, PI3K-Akt signaling pathways, and fatty acid metabolism pathway. These results suggest that CT is a promising therapeutic against metabolic disorders.
format	article
author	Mi Gyeong Jang Jung Min Oh Hee Chul Ko Jae-Won Kim Songyee Baek Yeong Jun Jin Sung-Pyo Hur Se-Jae Kim
author_facet	Mi Gyeong Jang Jung Min Oh Hee Chul Ko Jae-Won Kim Songyee Baek Yeong Jun Jin Sung-Pyo Hur Se-Jae Kim
author_sort	Mi Gyeong Jang
title	Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats
title_short	Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats
title_full	Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats
title_fullStr	Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats
title_full_unstemmed	Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats
title_sort	clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/9e22db6b0d1648f69a9daf0ce438c074
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Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats

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