Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers

Objective. The aim of the present study was to investigate the transcriptional activity of the GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin-induced diabetes in both untreated and treated with pentoxifylline, as a non-specific blocker of TNF-α.

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Autores principales:	Degen Anna S., Krynytska Inna Y., Kamyshnyi Aleksandr M.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	entero-insular axis mrna diabetes mellitus pentoxifylline Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/9e248494f2a24267ae224bfea6f6a009
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spelling	oai:doaj.org-article:9e248494f2a24267ae224bfea6f6a0092021-12-02T19:07:37ZChanges in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers1336-032910.2478/enr-2020-0019https://doaj.org/article/9e248494f2a24267ae224bfea6f6a0092020-07-01T00:00:00Zhttps://doi.org/10.2478/enr-2020-0019https://doaj.org/toc/1336-0329Objective. The aim of the present study was to investigate the transcriptional activity of the GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin-induced diabetes in both untreated and treated with pentoxifylline, as a non-specific blocker of TNF-α.Degen Anna S.Krynytska Inna Y.Kamyshnyi Aleksandr M.Sciendoarticleentero-insular axismrnadiabetes mellituspentoxifyllineDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 54, Iss 3, Pp 160-171 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	entero-insular axis mrna diabetes mellitus pentoxifylline Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	entero-insular axis mrna diabetes mellitus pentoxifylline Diseases of the endocrine glands. Clinical endocrinology RC648-665 Degen Anna S. Krynytska Inna Y. Kamyshnyi Aleksandr M. Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
description	Objective. The aim of the present study was to investigate the transcriptional activity of the GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin-induced diabetes in both untreated and treated with pentoxifylline, as a non-specific blocker of TNF-α.
format	article
author	Degen Anna S. Krynytska Inna Y. Kamyshnyi Aleksandr M.
author_facet	Degen Anna S. Krynytska Inna Y. Kamyshnyi Aleksandr M.
author_sort	Degen Anna S.
title	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_short	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_full	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_fullStr	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_full_unstemmed	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_sort	changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of tnf-α non-selective blockers
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/9e248494f2a24267ae224bfea6f6a009
work_keys_str_mv	AT degenannas changesinthetranscriptionalactivityoftheenteroinsularaxisgenesinstreptozotocininduceddiabetesandaftertheadministrationoftnfanonselectiveblockers AT krynytskainnay changesinthetranscriptionalactivityoftheenteroinsularaxisgenesinstreptozotocininduceddiabetesandaftertheadministrationoftnfanonselectiveblockers AT kamyshnyialeksandrm changesinthetranscriptionalactivityoftheenteroinsularaxisgenesinstreptozotocininduceddiabetesandaftertheadministrationoftnfanonselectiveblockers
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Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers

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