Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.

Neural tube defects are a common congenital anomaly involving incomplete closure of the spinal cord. Myelomeningocele (MMC) is a severe form in which there is complete exposure of neural tissue with a lack of skin, soft tissue, or bony covering to protect the spinal cord. The all-trans retinoic acid...

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Autores principales:	Nathan Maassel, James Farrelly, Daniel Coman, Mollie Freedman-Weiss, Samantha Ahle, Sarah Ullrich, Nicholas Yung, Fahmeed Hyder, David Stitelman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e25c29e5daa41eb862d55f65b30fd53
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spelling	oai:doaj.org-article:9e25c29e5daa41eb862d55f65b30fd532021-12-02T20:15:43ZDiffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.1932-620310.1371/journal.pone.0253583https://doaj.org/article/9e25c29e5daa41eb862d55f65b30fd532021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253583https://doaj.org/toc/1932-6203Neural tube defects are a common congenital anomaly involving incomplete closure of the spinal cord. Myelomeningocele (MMC) is a severe form in which there is complete exposure of neural tissue with a lack of skin, soft tissue, or bony covering to protect the spinal cord. The all-trans retinoic acid (ATRA) induced rat model of (MMC) is a reproducible, cost-effective means of studying this disease; however, there are limited modalities to objectively quantify disease severity, or potential benefits from experimental therapies. We sought to determine the feasibility of detecting differences between MMC and wild type (WT) rat fetuses using diffusion magnetic resonance imaging techniques (MRI). Rat dams were gavage-fed ATRA to produce MMC defects in fetuses, which were surgically delivered prior to term. Average diffusion coefficient (ADC) and fractional anisotropy (FA) maps were obtained for each fetus. Brain volumes and two anatomically defined brain length measurements (D1 and D2) were significantly decreased in MMC compared to WT. Mean ADC signal was significantly increased in MMC compared to WT, but no difference was found for FA signal. In summary, ADC and brain measurements were significantly different between WT and MMC rat fetuses. ADC could be a useful complementary imaging biomarker to current histopathologic analysis of MMC models, and potentially expedite therapeutic research for this disease.Nathan MaasselJames FarrellyDaniel ComanMollie Freedman-WeissSamantha AhleSarah UllrichNicholas YungFahmeed HyderDavid StitelmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253583 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nathan Maassel James Farrelly Daniel Coman Mollie Freedman-Weiss Samantha Ahle Sarah Ullrich Nicholas Yung Fahmeed Hyder David Stitelman Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.
description	Neural tube defects are a common congenital anomaly involving incomplete closure of the spinal cord. Myelomeningocele (MMC) is a severe form in which there is complete exposure of neural tissue with a lack of skin, soft tissue, or bony covering to protect the spinal cord. The all-trans retinoic acid (ATRA) induced rat model of (MMC) is a reproducible, cost-effective means of studying this disease; however, there are limited modalities to objectively quantify disease severity, or potential benefits from experimental therapies. We sought to determine the feasibility of detecting differences between MMC and wild type (WT) rat fetuses using diffusion magnetic resonance imaging techniques (MRI). Rat dams were gavage-fed ATRA to produce MMC defects in fetuses, which were surgically delivered prior to term. Average diffusion coefficient (ADC) and fractional anisotropy (FA) maps were obtained for each fetus. Brain volumes and two anatomically defined brain length measurements (D1 and D2) were significantly decreased in MMC compared to WT. Mean ADC signal was significantly increased in MMC compared to WT, but no difference was found for FA signal. In summary, ADC and brain measurements were significantly different between WT and MMC rat fetuses. ADC could be a useful complementary imaging biomarker to current histopathologic analysis of MMC models, and potentially expedite therapeutic research for this disease.
format	article
author	Nathan Maassel James Farrelly Daniel Coman Mollie Freedman-Weiss Samantha Ahle Sarah Ullrich Nicholas Yung Fahmeed Hyder David Stitelman
author_facet	Nathan Maassel James Farrelly Daniel Coman Mollie Freedman-Weiss Samantha Ahle Sarah Ullrich Nicholas Yung Fahmeed Hyder David Stitelman
author_sort	Nathan Maassel
title	Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.
title_short	Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.
title_full	Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.
title_fullStr	Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.
title_full_unstemmed	Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.
title_sort	diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9e25c29e5daa41eb862d55f65b30fd53
work_keys_str_mv	AT nathanmaassel diffusionweightedimagingasabiomarkerofretinoicacidinducedmyelomeningocele AT jamesfarrelly diffusionweightedimagingasabiomarkerofretinoicacidinducedmyelomeningocele AT danielcoman diffusionweightedimagingasabiomarkerofretinoicacidinducedmyelomeningocele AT molliefreedmanweiss diffusionweightedimagingasabiomarkerofretinoicacidinducedmyelomeningocele AT samanthaahle diffusionweightedimagingasabiomarkerofretinoicacidinducedmyelomeningocele AT sarahullrich diffusionweightedimagingasabiomarkerofretinoicacidinducedmyelomeningocele AT nicholasyung diffusionweightedimagingasabiomarkerofretinoicacidinducedmyelomeningocele AT fahmeedhyder diffusionweightedimagingasabiomarkerofretinoicacidinducedmyelomeningocele AT davidstitelman diffusionweightedimagingasabiomarkerofretinoicacidinducedmyelomeningocele
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Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele.

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