Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

Malignant rhabdoid tumours (MRT) have been suggested to originate in the ectoderm-derived neural crest. Here, the authors analyse MRTs using phylogenetics, scRNA-seq, and patient-derived organoids; they find evidence for an MRT origin in the neural crest lineage and suggest differentiation treatment...

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Autores principales:	Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e2c930bc7d3403e9e825b38fb4e38bf
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spelling	oai:doaj.org-article:9e2c930bc7d3403e9e825b38fb4e38bf2021-12-02T13:34:48ZSomatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours10.1038/s41467-021-21675-62041-1723https://doaj.org/article/9e2c930bc7d3403e9e825b38fb4e38bf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21675-6https://doaj.org/toc/2041-1723Malignant rhabdoid tumours (MRT) have been suggested to originate in the ectoderm-derived neural crest. Here, the authors analyse MRTs using phylogenetics, scRNA-seq, and patient-derived organoids; they find evidence for an MRT origin in the neural crest lineage and suggest differentiation treatment with HDAC/mTOR inhibitors.Lars CustersEleonora KhabirovaTim H. H. CoorensThomas R. W. OliverCamilla CalandriniMatthew D. YoungFelipe A. Vieira BragaPeter EllisLira MamanovaHeidi SegersArie MaatMarcel KoolEelco W. HovingMarry M. van den Heuvel-EibrinkJames NicholsonKarin StraathofLiz HookRonald R. de KrijgerClaire TrayersKieren AllinsonSam BehjatiJarno DrostNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lars Custers Eleonora Khabirova Tim H. H. Coorens Thomas R. W. Oliver Camilla Calandrini Matthew D. Young Felipe A. Vieira Braga Peter Ellis Lira Mamanova Heidi Segers Arie Maat Marcel Kool Eelco W. Hoving Marry M. van den Heuvel-Eibrink James Nicholson Karin Straathof Liz Hook Ronald R. de Krijger Claire Trayers Kieren Allinson Sam Behjati Jarno Drost Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
description	Malignant rhabdoid tumours (MRT) have been suggested to originate in the ectoderm-derived neural crest. Here, the authors analyse MRTs using phylogenetics, scRNA-seq, and patient-derived organoids; they find evidence for an MRT origin in the neural crest lineage and suggest differentiation treatment with HDAC/mTOR inhibitors.
format	article
author	Lars Custers Eleonora Khabirova Tim H. H. Coorens Thomas R. W. Oliver Camilla Calandrini Matthew D. Young Felipe A. Vieira Braga Peter Ellis Lira Mamanova Heidi Segers Arie Maat Marcel Kool Eelco W. Hoving Marry M. van den Heuvel-Eibrink James Nicholson Karin Straathof Liz Hook Ronald R. de Krijger Claire Trayers Kieren Allinson Sam Behjati Jarno Drost
author_facet	Lars Custers Eleonora Khabirova Tim H. H. Coorens Thomas R. W. Oliver Camilla Calandrini Matthew D. Young Felipe A. Vieira Braga Peter Ellis Lira Mamanova Heidi Segers Arie Maat Marcel Kool Eelco W. Hoving Marry M. van den Heuvel-Eibrink James Nicholson Karin Straathof Liz Hook Ronald R. de Krijger Claire Trayers Kieren Allinson Sam Behjati Jarno Drost
author_sort	Lars Custers
title	Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
title_short	Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
title_full	Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
title_fullStr	Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
title_full_unstemmed	Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
title_sort	somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e2c930bc7d3403e9e825b38fb4e38bf
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Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

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