Evaluation of connectivity map shows limited reproducibility in drug repositioning

Abstract The Connectivity Map (CMap) is a popular resource designed for data-driven drug repositioning using a large transcriptomic compendium. However, evaluations of its performance are limited. We used two iterations of CMap (CMap 1 and 2) to assess their comparability and reliability. We queried...

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Autores principales: Nathaniel Lim, Paul Pavlidis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9e2c9782c48e4f3c8dd4b0ba6b14221c
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