The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.

<h4>Purpose</h4>To examine the relationship between pre-corneal and pre-contact lens tear film stability (TFS), and to determine whether pre-corneal TFS is a reliable predictor of subsequent pre-lens TFS after a contact lens is placed on the eye.<h4>Methods</h4>667 records me...

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Autores principales:	Andrew D Graham, Meng C Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e3085adbd214dbeb627d32a11e15837
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spelling	oai:doaj.org-article:9e3085adbd214dbeb627d32a11e158372021-12-02T20:09:56ZThe relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.1932-620310.1371/journal.pone.0247877https://doaj.org/article/9e3085adbd214dbeb627d32a11e158372021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0247877https://doaj.org/toc/1932-6203<h4>Purpose</h4>To examine the relationship between pre-corneal and pre-contact lens tear film stability (TFS), and to determine whether pre-corneal TFS is a reliable predictor of subsequent pre-lens TFS after a contact lens is placed on the eye.<h4>Methods</h4>667 records met inclusion criteria and were extracted from a soft contact lens multi-study database. Multivariable linear mixed effects models were fit to examine the association between pre-corneal and pre-lens TFS, adjusting for potential confounders and accounting for repeated measures. Receiver Operating Characteristic (ROC) analysis was employed to assess the predictive performance of pre-corneal TFS for subsequent pre-lens TFS. TFS was quantified for this analysis as the non-invasive tear breakup time (NITBUT).<h4>Results</h4>Pre-corneal NITBUT was significantly related to the pre-lens NITBUT at both 10 min (p<0.001) and 2-6 hrs (p<0.001) post-lens insertion. However, the sensitivities of pre-corneal NITBUT for predicting symptom-associated thresholds of pre-lens NITBUT ranged from 50-65%, and specificities ranged from 57-72%, suggesting poor-to-moderate diagnostic performance.<h4>Conclusions</h4>Despite the association of pre-corneal and pre-lens TFS, the inherent lability and sensitivity to environmental exposures of the tear film introduce significant variability into NITBUT measurements. Using pre-corneal NITBUT to identify likely successful contact lens candidates prior to fitting is thus not sufficiently accurate to be relied upon in the clinical setting.Andrew D GrahamMeng C LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0247877 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrew D Graham Meng C Lin The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.
description	<h4>Purpose</h4>To examine the relationship between pre-corneal and pre-contact lens tear film stability (TFS), and to determine whether pre-corneal TFS is a reliable predictor of subsequent pre-lens TFS after a contact lens is placed on the eye.<h4>Methods</h4>667 records met inclusion criteria and were extracted from a soft contact lens multi-study database. Multivariable linear mixed effects models were fit to examine the association between pre-corneal and pre-lens TFS, adjusting for potential confounders and accounting for repeated measures. Receiver Operating Characteristic (ROC) analysis was employed to assess the predictive performance of pre-corneal TFS for subsequent pre-lens TFS. TFS was quantified for this analysis as the non-invasive tear breakup time (NITBUT).<h4>Results</h4>Pre-corneal NITBUT was significantly related to the pre-lens NITBUT at both 10 min (p<0.001) and 2-6 hrs (p<0.001) post-lens insertion. However, the sensitivities of pre-corneal NITBUT for predicting symptom-associated thresholds of pre-lens NITBUT ranged from 50-65%, and specificities ranged from 57-72%, suggesting poor-to-moderate diagnostic performance.<h4>Conclusions</h4>Despite the association of pre-corneal and pre-lens TFS, the inherent lability and sensitivity to environmental exposures of the tear film introduce significant variability into NITBUT measurements. Using pre-corneal NITBUT to identify likely successful contact lens candidates prior to fitting is thus not sufficiently accurate to be relied upon in the clinical setting.
format	article
author	Andrew D Graham Meng C Lin
author_facet	Andrew D Graham Meng C Lin
author_sort	Andrew D Graham
title	The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.
title_short	The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.
title_full	The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.
title_fullStr	The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.
title_full_unstemmed	The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.
title_sort	relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9e3085adbd214dbeb627d32a11e15837
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The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time.

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