Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models

Abstract Heart diseases are associated with changes in the biomechanical properties of the myocardial wall. However, there is no modality available to assess myocardial stiffness directly. Brillouin microspectroscopy (mBS) is a consolidated mechanical characterization technique, applied to the study...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	María Villalba-Orero, Rafael J. Jiménez-Riobóo, Nuria Gontán, Daniel Sanderson, Marina López-Olañeta, Pablo García-Pavía, Manuel Desco, Enrique Lara-Pezzi, Maria Victoria Gómez-Gaviro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e31b42098c045219dd2e96c6340751e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e31b42098c045219dd2e96c6340751e
record_format	dspace
spelling	oai:doaj.org-article:9e31b42098c045219dd2e96c6340751e2021-11-08T10:48:49ZAssessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models10.1038/s41598-021-00661-42045-2322https://doaj.org/article/9e31b42098c045219dd2e96c6340751e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00661-4https://doaj.org/toc/2045-2322Abstract Heart diseases are associated with changes in the biomechanical properties of the myocardial wall. However, there is no modality available to assess myocardial stiffness directly. Brillouin microspectroscopy (mBS) is a consolidated mechanical characterization technique, applied to the study of the viscoelastic and elastic behavior of biological samples and may be a valuable tool for assessing the viscoelastic properties of the cardiac tissue. In this work, viscosity and elasticity were assessed using mBS in heart samples obtained from healthy and unhealthy mice (n = 6 per group). Speckle-tracking echocardiography (STE) was performed to evaluate heart deformation. We found that mBS was able to detect changes in stiffness in the ventricles in healthy myocardium. The right ventricle showed reduced stiffness, in agreement with its increased compliance. mBS measurements correlated strongly with STE data, highlighting the association between displacement and stiffness in myocardial regions. This correlation was lost in pathological conditions studied. The scar region in the infarcted heart presented changes in stiffness when compared to the rest of the heart, and the hypertrophied left ventricle showed increased stiffness following aortic stenosis, compared to the right ventricle. We demonstrate that mBS can be applied to determine myocardial stiffness, that measurements correlate with functional parameters and that they change with disease.María Villalba-OreroRafael J. Jiménez-RiobóoNuria GontánDaniel SandersonMarina López-OlañetaPablo García-PavíaManuel DescoEnrique Lara-PezziMaria Victoria Gómez-GaviroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q María Villalba-Orero Rafael J. Jiménez-Riobóo Nuria Gontán Daniel Sanderson Marina López-Olañeta Pablo García-Pavía Manuel Desco Enrique Lara-Pezzi Maria Victoria Gómez-Gaviro Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models
description	Abstract Heart diseases are associated with changes in the biomechanical properties of the myocardial wall. However, there is no modality available to assess myocardial stiffness directly. Brillouin microspectroscopy (mBS) is a consolidated mechanical characterization technique, applied to the study of the viscoelastic and elastic behavior of biological samples and may be a valuable tool for assessing the viscoelastic properties of the cardiac tissue. In this work, viscosity and elasticity were assessed using mBS in heart samples obtained from healthy and unhealthy mice (n = 6 per group). Speckle-tracking echocardiography (STE) was performed to evaluate heart deformation. We found that mBS was able to detect changes in stiffness in the ventricles in healthy myocardium. The right ventricle showed reduced stiffness, in agreement with its increased compliance. mBS measurements correlated strongly with STE data, highlighting the association between displacement and stiffness in myocardial regions. This correlation was lost in pathological conditions studied. The scar region in the infarcted heart presented changes in stiffness when compared to the rest of the heart, and the hypertrophied left ventricle showed increased stiffness following aortic stenosis, compared to the right ventricle. We demonstrate that mBS can be applied to determine myocardial stiffness, that measurements correlate with functional parameters and that they change with disease.
format	article
author	María Villalba-Orero Rafael J. Jiménez-Riobóo Nuria Gontán Daniel Sanderson Marina López-Olañeta Pablo García-Pavía Manuel Desco Enrique Lara-Pezzi Maria Victoria Gómez-Gaviro
author_facet	María Villalba-Orero Rafael J. Jiménez-Riobóo Nuria Gontán Daniel Sanderson Marina López-Olañeta Pablo García-Pavía Manuel Desco Enrique Lara-Pezzi Maria Victoria Gómez-Gaviro
author_sort	María Villalba-Orero
title	Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models
title_short	Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models
title_full	Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models
title_fullStr	Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models
title_full_unstemmed	Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models
title_sort	assessment of myocardial viscoelasticity with brillouin spectroscopy in myocardial infarction and aortic stenosis models
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e31b42098c045219dd2e96c6340751e
work_keys_str_mv	AT mariavillalbaorero assessmentofmyocardialviscoelasticitywithbrillouinspectroscopyinmyocardialinfarctionandaorticstenosismodels AT rafaeljjimenezrioboo assessmentofmyocardialviscoelasticitywithbrillouinspectroscopyinmyocardialinfarctionandaorticstenosismodels AT nuriagontan assessmentofmyocardialviscoelasticitywithbrillouinspectroscopyinmyocardialinfarctionandaorticstenosismodels AT danielsanderson assessmentofmyocardialviscoelasticitywithbrillouinspectroscopyinmyocardialinfarctionandaorticstenosismodels AT marinalopezolaneta assessmentofmyocardialviscoelasticitywithbrillouinspectroscopyinmyocardialinfarctionandaorticstenosismodels AT pablogarciapavia assessmentofmyocardialviscoelasticitywithbrillouinspectroscopyinmyocardialinfarctionandaorticstenosismodels AT manueldesco assessmentofmyocardialviscoelasticitywithbrillouinspectroscopyinmyocardialinfarctionandaorticstenosismodels AT enriquelarapezzi assessmentofmyocardialviscoelasticitywithbrillouinspectroscopyinmyocardialinfarctionandaorticstenosismodels AT mariavictoriagomezgaviro assessmentofmyocardialviscoelasticitywithbrillouinspectroscopyinmyocardialinfarctionandaorticstenosismodels
_version_	1718442646161063936

Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models

Ejemplares similares