Deep-coverage whole genome sequences and blood lipids among 16,324 individuals
Common genetic variants associated with plasma lipids have been extensively studied for a better understanding of common diseases. Here, the authors use whole-genome sequencing of 16,324 individuals to analyze rare variant associations and to determine their monogenic and polygenic contribution to l...
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Nature Portfolio
2018
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oai:doaj.org-article:9e3763d9201a473097a59d1dfd1ef3d82021-12-02T14:40:08ZDeep-coverage whole genome sequences and blood lipids among 16,324 individuals10.1038/s41467-018-05747-82041-1723https://doaj.org/article/9e3763d9201a473097a59d1dfd1ef3d82018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05747-8https://doaj.org/toc/2041-1723Common genetic variants associated with plasma lipids have been extensively studied for a better understanding of common diseases. Here, the authors use whole-genome sequencing of 16,324 individuals to analyze rare variant associations and to determine their monogenic and polygenic contribution to lipid traits.Pradeep NatarajanGina M. PelosoSeyedeh Maryam ZekavatMay MontasserAndrea GannaMark ChaffinAmit V. KheraWei ZhouJonathan M. BloomJesse M. EngreitzJason ErnstJeffrey R. O’ConnellSanni E. RuotsalainenMaris AlverAni ManichaikulW. Craig JohnsonJames A. PerryTimothy PoterbaCotton SeedIda L. SurakkaTonu EskoSamuli RipattiVeikko SalomaaAdolfo CorreaRamachandran S. VasanManolis KellisBenjamin M. NealeEric S. LanderGoncalo AbecasisBraxton MitchellStephen S. RichJames G. WilsonL. Adrienne CupplesJerome I. RotterCristen J. WillerSekar KathiresanNHLBI TOPMed Lipids Working GroupNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Pradeep Natarajan Gina M. Peloso Seyedeh Maryam Zekavat May Montasser Andrea Ganna Mark Chaffin Amit V. Khera Wei Zhou Jonathan M. Bloom Jesse M. Engreitz Jason Ernst Jeffrey R. O’Connell Sanni E. Ruotsalainen Maris Alver Ani Manichaikul W. Craig Johnson James A. Perry Timothy Poterba Cotton Seed Ida L. Surakka Tonu Esko Samuli Ripatti Veikko Salomaa Adolfo Correa Ramachandran S. Vasan Manolis Kellis Benjamin M. Neale Eric S. Lander Goncalo Abecasis Braxton Mitchell Stephen S. Rich James G. Wilson L. Adrienne Cupples Jerome I. Rotter Cristen J. Willer Sekar Kathiresan NHLBI TOPMed Lipids Working Group Deep-coverage whole genome sequences and blood lipids among 16,324 individuals |
| description |
Common genetic variants associated with plasma lipids have been extensively studied for a better understanding of common diseases. Here, the authors use whole-genome sequencing of 16,324 individuals to analyze rare variant associations and to determine their monogenic and polygenic contribution to lipid traits. |
| format |
article |
| author |
Pradeep Natarajan Gina M. Peloso Seyedeh Maryam Zekavat May Montasser Andrea Ganna Mark Chaffin Amit V. Khera Wei Zhou Jonathan M. Bloom Jesse M. Engreitz Jason Ernst Jeffrey R. O’Connell Sanni E. Ruotsalainen Maris Alver Ani Manichaikul W. Craig Johnson James A. Perry Timothy Poterba Cotton Seed Ida L. Surakka Tonu Esko Samuli Ripatti Veikko Salomaa Adolfo Correa Ramachandran S. Vasan Manolis Kellis Benjamin M. Neale Eric S. Lander Goncalo Abecasis Braxton Mitchell Stephen S. Rich James G. Wilson L. Adrienne Cupples Jerome I. Rotter Cristen J. Willer Sekar Kathiresan NHLBI TOPMed Lipids Working Group |
| author_facet |
Pradeep Natarajan Gina M. Peloso Seyedeh Maryam Zekavat May Montasser Andrea Ganna Mark Chaffin Amit V. Khera Wei Zhou Jonathan M. Bloom Jesse M. Engreitz Jason Ernst Jeffrey R. O’Connell Sanni E. Ruotsalainen Maris Alver Ani Manichaikul W. Craig Johnson James A. Perry Timothy Poterba Cotton Seed Ida L. Surakka Tonu Esko Samuli Ripatti Veikko Salomaa Adolfo Correa Ramachandran S. Vasan Manolis Kellis Benjamin M. Neale Eric S. Lander Goncalo Abecasis Braxton Mitchell Stephen S. Rich James G. Wilson L. Adrienne Cupples Jerome I. Rotter Cristen J. Willer Sekar Kathiresan NHLBI TOPMed Lipids Working Group |
| author_sort |
Pradeep Natarajan |
| title |
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals |
| title_short |
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals |
| title_full |
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals |
| title_fullStr |
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals |
| title_full_unstemmed |
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals |
| title_sort |
deep-coverage whole genome sequences and blood lipids among 16,324 individuals |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/9e3763d9201a473097a59d1dfd1ef3d8 |
| work_keys_str_mv |
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| _version_ |
1718390433002815488 |