Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma

Nicholas Wride1, Majed Habib1, Keith Morris2, Steve Campbell3, Scott Fraser11Sunderland Eye Infirmary, City Hospitals Sunderland NHS Foundation Trust, Sunderland, Tyne and Wear, UK; 2Applied Neurodiagnostics Ltd, Cramlington, Northumberland, UK; 3School of Health, University of New England, New Sout...

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Autores principales:	Nicholas Wride, Majed Habib, Keith Morris, Steve Campbell, Scott Fraser
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9e38a36c79934e32892234992a5b8690
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spelling	oai:doaj.org-article:9e38a36c79934e32892234992a5b86902021-12-02T00:13:46ZClinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma1177-54671177-5483https://doaj.org/article/9e38a36c79934e32892234992a5b86902008-12-01T00:00:00Zhttp://www.dovepress.com/clinical-evaluation-of-a-rapid-pupil-based-assessment-of-retinal-damag-a2708https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Nicholas Wride1, Majed Habib1, Keith Morris2, Steve Campbell3, Scott Fraser11Sunderland Eye Infirmary, City Hospitals Sunderland NHS Foundation Trust, Sunderland, Tyne and Wear, UK; 2Applied Neurodiagnostics Ltd, Cramlington, Northumberland, UK; 3School of Health, University of New England, New South Wales, AustraliaAims: To evaluate the effectiveness of a new test, the Pupilmetrix&trade; PLR60, which uses the pupillary light reflex (PLR) to detect asymmetric retinal damage in patients diagnosed with glaucoma.Methods: 30 patients, clinically diagnosed as having glaucoma, were recruited to the study, 29 of whom completed testing using the PLR60. A control group of 30 patients who had glaucoma excluded by clinical examination were also recruited and tested using the same protocol on the PLR60.Results: Of the 110 eyes with test outcomes, overall agreement between the PLR60 result and clinical diagnosis (glaucoma positive or negative) per eye was 84.7%. Sensitivity was 93.1% (95% CI 77.2%&ndash;99.2%) and specificity was 76.7% (95% CI 57.7%&ndash;90.1%). Average (SD) test times (min:sec) for both eyes were 3:21 (0:33) minutes for the glaucoma group and 2:40 (0:35) minutes for the non-glaucoma group.Conclusions: The results of this preliminary study suggest that the PLR as used in the Pupilmetrix&trade; PLR60 test is able to discriminate between patients with glaucomatous retinal defects and those with clinically normal retinas with a diagnostic accuracy that is potentially useful for screening for glaucoma. Test times were markedly quicker than with standard visual field testing.Keywords: glaucoma, pupillary light reflex, retina, Pupilmetrix Nicholas WrideMajed HabibKeith MorrisSteve CampbellScott FraserDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 123-128 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Nicholas Wride Majed Habib Keith Morris Steve Campbell Scott Fraser Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma
description	Nicholas Wride1, Majed Habib1, Keith Morris2, Steve Campbell3, Scott Fraser11Sunderland Eye Infirmary, City Hospitals Sunderland NHS Foundation Trust, Sunderland, Tyne and Wear, UK; 2Applied Neurodiagnostics Ltd, Cramlington, Northumberland, UK; 3School of Health, University of New England, New South Wales, AustraliaAims: To evaluate the effectiveness of a new test, the Pupilmetrix&trade; PLR60, which uses the pupillary light reflex (PLR) to detect asymmetric retinal damage in patients diagnosed with glaucoma.Methods: 30 patients, clinically diagnosed as having glaucoma, were recruited to the study, 29 of whom completed testing using the PLR60. A control group of 30 patients who had glaucoma excluded by clinical examination were also recruited and tested using the same protocol on the PLR60.Results: Of the 110 eyes with test outcomes, overall agreement between the PLR60 result and clinical diagnosis (glaucoma positive or negative) per eye was 84.7%. Sensitivity was 93.1% (95% CI 77.2%&ndash;99.2%) and specificity was 76.7% (95% CI 57.7%&ndash;90.1%). Average (SD) test times (min:sec) for both eyes were 3:21 (0:33) minutes for the glaucoma group and 2:40 (0:35) minutes for the non-glaucoma group.Conclusions: The results of this preliminary study suggest that the PLR as used in the Pupilmetrix&trade; PLR60 test is able to discriminate between patients with glaucomatous retinal defects and those with clinically normal retinas with a diagnostic accuracy that is potentially useful for screening for glaucoma. Test times were markedly quicker than with standard visual field testing.Keywords: glaucoma, pupillary light reflex, retina, Pupilmetrix
format	article
author	Nicholas Wride Majed Habib Keith Morris Steve Campbell Scott Fraser
author_facet	Nicholas Wride Majed Habib Keith Morris Steve Campbell Scott Fraser
author_sort	Nicholas Wride
title	Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma
title_short	Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma
title_full	Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma
title_fullStr	Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma
title_full_unstemmed	Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma
title_sort	clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/9e38a36c79934e32892234992a5b8690
work_keys_str_mv	AT nicholaswride clinicalevaluationofarapidpupilbasedassessmentofretinaldamageassociatedwithglaucoma AT majedhabib clinicalevaluationofarapidpupilbasedassessmentofretinaldamageassociatedwithglaucoma AT keithmorris clinicalevaluationofarapidpupilbasedassessmentofretinaldamageassociatedwithglaucoma AT stevecampbell clinicalevaluationofarapidpupilbasedassessmentofretinaldamageassociatedwithglaucoma AT scottfraser clinicalevaluationofarapidpupilbasedassessmentofretinaldamageassociatedwithglaucoma
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Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma

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