Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.

<h4>Background</h4>Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like receptors (TLRs), innate immune receptors which govern tailore...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eric J Downer, Raasay S Jones, Claire L McDonald, Eleonora Greco, Sabina Brennan, Thomas J Connor, Ian H Robertson, Marina A Lynch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e38fa3a402544f0b9ce616e6b518ad6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e38fa3a402544f0b9ce616e6b518ad6
record_format	dspace
spelling	oai:doaj.org-article:9e38fa3a402544f0b9ce616e6b518ad62021-11-18T07:46:47ZIdentifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.1932-620310.1371/journal.pone.0063194https://doaj.org/article/9e38fa3a402544f0b9ce616e6b518ad62013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23671673/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like receptors (TLRs), innate immune receptors which govern tailored inflammatory gene expression patterns. Monocytes, which produce pro-inflammatory mediators, are readily recruited to the central nervous system (CNS) in neurodegenerative diseases.<h4>Methods</h4>This study explored the expression of receptors (CD11b, TLR2 and TLR4) on circulating monocyte-derived macrophages (MDMs) and peripheral blood mononuclear cells (PBMCs) isolated from healthy elderly adults who we classified as either IQ memory-consistent (high-performing, HP) or IQ memory-discrepant (low-performing, LP).<h4>Results</h4>The expression of CD11b, TLR4 and TLR2 was increased in MDMs from the LP group when compared to HP cohort. MDMs from both groups responded robustly to treatment with the TLR4 activator, lipopolysaccharide (LPS), in terms of cytokine production. Significantly, MDMs from the LP group displayed hypersensitivity to LPS exposure.<h4>Interpretation</h4>Overall these findings define differential receptor expression and cytokine profiles that occur in MDMs derived from a cohort of IQ memory-discrepant individuals. These changes are indicative of inflammation and may be involved in the prodromal processes leading to the development of neurodegenerative disease.Eric J DownerRaasay S JonesClaire L McDonaldEleonora GrecoSabina BrennanThomas J ConnorIan H RobertsonMarina A LynchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63194 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eric J Downer Raasay S Jones Claire L McDonald Eleonora Greco Sabina Brennan Thomas J Connor Ian H Robertson Marina A Lynch Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.
description	<h4>Background</h4>Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like receptors (TLRs), innate immune receptors which govern tailored inflammatory gene expression patterns. Monocytes, which produce pro-inflammatory mediators, are readily recruited to the central nervous system (CNS) in neurodegenerative diseases.<h4>Methods</h4>This study explored the expression of receptors (CD11b, TLR2 and TLR4) on circulating monocyte-derived macrophages (MDMs) and peripheral blood mononuclear cells (PBMCs) isolated from healthy elderly adults who we classified as either IQ memory-consistent (high-performing, HP) or IQ memory-discrepant (low-performing, LP).<h4>Results</h4>The expression of CD11b, TLR4 and TLR2 was increased in MDMs from the LP group when compared to HP cohort. MDMs from both groups responded robustly to treatment with the TLR4 activator, lipopolysaccharide (LPS), in terms of cytokine production. Significantly, MDMs from the LP group displayed hypersensitivity to LPS exposure.<h4>Interpretation</h4>Overall these findings define differential receptor expression and cytokine profiles that occur in MDMs derived from a cohort of IQ memory-discrepant individuals. These changes are indicative of inflammation and may be involved in the prodromal processes leading to the development of neurodegenerative disease.
format	article
author	Eric J Downer Raasay S Jones Claire L McDonald Eleonora Greco Sabina Brennan Thomas J Connor Ian H Robertson Marina A Lynch
author_facet	Eric J Downer Raasay S Jones Claire L McDonald Eleonora Greco Sabina Brennan Thomas J Connor Ian H Robertson Marina A Lynch
author_sort	Eric J Downer
title	Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.
title_short	Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.
title_full	Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.
title_fullStr	Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.
title_full_unstemmed	Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.
title_sort	identifying early inflammatory changes in monocyte-derived macrophages from a population with iq-discrepant episodic memory.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9e38fa3a402544f0b9ce616e6b518ad6
work_keys_str_mv	AT ericjdowner identifyingearlyinflammatorychangesinmonocytederivedmacrophagesfromapopulationwithiqdiscrepantepisodicmemory AT raasaysjones identifyingearlyinflammatorychangesinmonocytederivedmacrophagesfromapopulationwithiqdiscrepantepisodicmemory AT clairelmcdonald identifyingearlyinflammatorychangesinmonocytederivedmacrophagesfromapopulationwithiqdiscrepantepisodicmemory AT eleonoragreco identifyingearlyinflammatorychangesinmonocytederivedmacrophagesfromapopulationwithiqdiscrepantepisodicmemory AT sabinabrennan identifyingearlyinflammatorychangesinmonocytederivedmacrophagesfromapopulationwithiqdiscrepantepisodicmemory AT thomasjconnor identifyingearlyinflammatorychangesinmonocytederivedmacrophagesfromapopulationwithiqdiscrepantepisodicmemory AT ianhrobertson identifyingearlyinflammatorychangesinmonocytederivedmacrophagesfromapopulationwithiqdiscrepantepisodicmemory AT marinaalynch identifyingearlyinflammatorychangesinmonocytederivedmacrophagesfromapopulationwithiqdiscrepantepisodicmemory
_version_	1718422991296004096

Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.

Ejemplares similares