Comorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012: A multicentre, nationwide, retrospective study in China

Abstract Parkinson’s disease (PD) and Parkinsonism are common neurodegenerative disorders with continuously increasing prevalence, causing high global burdens. However, data concerning the comorbidity burden of patients with PD or Parkinsonism in China are lacking. To investigate the health conditio...

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Autores principales:	Xin Wang, Fan Zeng, Wang-Sheng Jin, Chi Zhu, Qing-Hua Wang, Xian-Le Bu, Hong-Bo Luo, Hai-Qiang Zou, Jie Pu, Zhong-He Zhou, Xiao-Ping Cui, Qing-Song Wang, Xiang-Qun Shi, Wei Han, Qiang Wu, Hui-Sheng Chen, Hang Lin, Li-Li Zhang, Meng Zhang, Yan Lian, Zhi-Qiang Xu, Hua-Dong Zhou, Tao Zhang, Yan-Jiang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e39d4c3280f415fb0fb5e4ebbe40ea2
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spelling	oai:doaj.org-article:9e39d4c3280f415fb0fb5e4ebbe40ea22021-12-02T12:30:34ZComorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012: A multicentre, nationwide, retrospective study in China10.1038/s41598-017-01795-02045-2322https://doaj.org/article/9e39d4c3280f415fb0fb5e4ebbe40ea22017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01795-0https://doaj.org/toc/2045-2322Abstract Parkinson’s disease (PD) and Parkinsonism are common neurodegenerative disorders with continuously increasing prevalence, causing high global burdens. However, data concerning the comorbidity burden of patients with PD or Parkinsonism in China are lacking. To investigate the health condition and comorbidity burden, a total of 3367 PD and 823 Parkinsonism patients were included from seven tertiary hospitals in seven cities across China from 2003 to 2012. Their comorbidity burden was collected and quantified by the Elixhauser Comorbidity Index (ECI) and Charlson Comorbidity Index (CCI). The comorbidity spectra differed between PD and Parkinsonism patients. Compared with PD patients, Parkinsonism patients were older (69.8 ± 11.5 vs. 67.9 ± 11.4, P < 0.001); had a higher comorbidity burden, including ECI (1.1 ± 1.2 vs. 1.0 ± 1.2, P < 0.001) and CCI (1.3 ± 1.6 vs. 1.1 ± 1.5, P < 0.001); and had higher hospitalization expenses. The ECI (1.1 ± 1.3 vs. 0.9 ± 1.1, P < 0.001) and CCI (1.3 ± 1.6 vs. 0.9 ± 1.2, P < 0.001) were higher in males than in females. The average length of stay and daily hospitalization expenses increased with age, as did ECI and CCI. This is the first study to report the disease burden of Chinese PD and Parkinsonism patients. It provides useful information to better understand their health status, and to raise the awareness of clinicians for providing better health care.Xin WangFan ZengWang-Sheng JinChi ZhuQing-Hua WangXian-Le BuHong-Bo LuoHai-Qiang ZouJie PuZhong-He ZhouXiao-Ping CuiQing-Song WangXiang-Qun ShiWei HanQiang WuHui-Sheng ChenHang LinLi-Li ZhangMeng ZhangYan LianZhi-Qiang XuHua-Dong ZhouTao ZhangYan-Jiang WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Wang Fan Zeng Wang-Sheng Jin Chi Zhu Qing-Hua Wang Xian-Le Bu Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Li-Li Zhang Meng Zhang Yan Lian Zhi-Qiang Xu Hua-Dong Zhou Tao Zhang Yan-Jiang Wang Comorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012: A multicentre, nationwide, retrospective study in China
description	Abstract Parkinson’s disease (PD) and Parkinsonism are common neurodegenerative disorders with continuously increasing prevalence, causing high global burdens. However, data concerning the comorbidity burden of patients with PD or Parkinsonism in China are lacking. To investigate the health condition and comorbidity burden, a total of 3367 PD and 823 Parkinsonism patients were included from seven tertiary hospitals in seven cities across China from 2003 to 2012. Their comorbidity burden was collected and quantified by the Elixhauser Comorbidity Index (ECI) and Charlson Comorbidity Index (CCI). The comorbidity spectra differed between PD and Parkinsonism patients. Compared with PD patients, Parkinsonism patients were older (69.8 ± 11.5 vs. 67.9 ± 11.4, P < 0.001); had a higher comorbidity burden, including ECI (1.1 ± 1.2 vs. 1.0 ± 1.2, P < 0.001) and CCI (1.3 ± 1.6 vs. 1.1 ± 1.5, P < 0.001); and had higher hospitalization expenses. The ECI (1.1 ± 1.3 vs. 0.9 ± 1.1, P < 0.001) and CCI (1.3 ± 1.6 vs. 0.9 ± 1.2, P < 0.001) were higher in males than in females. The average length of stay and daily hospitalization expenses increased with age, as did ECI and CCI. This is the first study to report the disease burden of Chinese PD and Parkinsonism patients. It provides useful information to better understand their health status, and to raise the awareness of clinicians for providing better health care.
format	article
author	Xin Wang Fan Zeng Wang-Sheng Jin Chi Zhu Qing-Hua Wang Xian-Le Bu Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Li-Li Zhang Meng Zhang Yan Lian Zhi-Qiang Xu Hua-Dong Zhou Tao Zhang Yan-Jiang Wang
author_facet	Xin Wang Fan Zeng Wang-Sheng Jin Chi Zhu Qing-Hua Wang Xian-Le Bu Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Li-Li Zhang Meng Zhang Yan Lian Zhi-Qiang Xu Hua-Dong Zhou Tao Zhang Yan-Jiang Wang
author_sort	Xin Wang
title	Comorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012: A multicentre, nationwide, retrospective study in China
title_short	Comorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012: A multicentre, nationwide, retrospective study in China
title_full	Comorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012: A multicentre, nationwide, retrospective study in China
title_fullStr	Comorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012: A multicentre, nationwide, retrospective study in China
title_full_unstemmed	Comorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012: A multicentre, nationwide, retrospective study in China
title_sort	comorbidity burden of patients with parkinson’s disease and parkinsonism between 2003 and 2012: a multicentre, nationwide, retrospective study in china
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9e39d4c3280f415fb0fb5e4ebbe40ea2
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Comorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012: A multicentre, nationwide, retrospective study in China

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