Immune Tolerance in the Oral Mucosa

The oral mucosa is a site of intense immune activity, where a large variety of immune cells meet to provide a first line of defense against pathogenic organisms. Interestingly, the oral mucosa is exposed to a plethora of antigens from food and commensal bacteria that must be tolerated. The mechanism...

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Autores principales:	Hector F. Pelaez-Prestel, Jose L. Sanchez-Trincado, Esther M. Lafuente, Pedro A. Reche
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oral mucosa tolerance T cell dendritic cell epithelial cell Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9e3c3eef15d34a43903c0af11c695e4e
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spelling	oai:doaj.org-article:9e3c3eef15d34a43903c0af11c695e4e2021-11-25T17:53:49ZImmune Tolerance in the Oral Mucosa10.3390/ijms2222121491422-00671661-6596https://doaj.org/article/9e3c3eef15d34a43903c0af11c695e4e2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12149https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The oral mucosa is a site of intense immune activity, where a large variety of immune cells meet to provide a first line of defense against pathogenic organisms. Interestingly, the oral mucosa is exposed to a plethora of antigens from food and commensal bacteria that must be tolerated. The mechanisms that enable this tolerance are not yet fully defined. Many works have focused on active immune mechanisms involving dendritic and regulatory T cells. However, epithelial cells also make a major contribution to tolerance by influencing both innate and adaptive immunity. Therefore, the tolerogenic mechanisms concurring in the oral mucosa are intertwined. Here, we review them systematically, paying special attention to the role of oral epithelial cells.Hector F. Pelaez-PrestelJose L. Sanchez-TrincadoEsther M. LafuentePedro A. RecheMDPI AGarticleoralmucosatoleranceT celldendritic cellepithelial cellBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12149, p 12149 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral mucosa tolerance T cell dendritic cell epithelial cell Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	oral mucosa tolerance T cell dendritic cell epithelial cell Biology (General) QH301-705.5 Chemistry QD1-999 Hector F. Pelaez-Prestel Jose L. Sanchez-Trincado Esther M. Lafuente Pedro A. Reche Immune Tolerance in the Oral Mucosa
description	The oral mucosa is a site of intense immune activity, where a large variety of immune cells meet to provide a first line of defense against pathogenic organisms. Interestingly, the oral mucosa is exposed to a plethora of antigens from food and commensal bacteria that must be tolerated. The mechanisms that enable this tolerance are not yet fully defined. Many works have focused on active immune mechanisms involving dendritic and regulatory T cells. However, epithelial cells also make a major contribution to tolerance by influencing both innate and adaptive immunity. Therefore, the tolerogenic mechanisms concurring in the oral mucosa are intertwined. Here, we review them systematically, paying special attention to the role of oral epithelial cells.
format	article
author	Hector F. Pelaez-Prestel Jose L. Sanchez-Trincado Esther M. Lafuente Pedro A. Reche
author_facet	Hector F. Pelaez-Prestel Jose L. Sanchez-Trincado Esther M. Lafuente Pedro A. Reche
author_sort	Hector F. Pelaez-Prestel
title	Immune Tolerance in the Oral Mucosa
title_short	Immune Tolerance in the Oral Mucosa
title_full	Immune Tolerance in the Oral Mucosa
title_fullStr	Immune Tolerance in the Oral Mucosa
title_full_unstemmed	Immune Tolerance in the Oral Mucosa
title_sort	immune tolerance in the oral mucosa
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9e3c3eef15d34a43903c0af11c695e4e
work_keys_str_mv	AT hectorfpelaezprestel immunetoleranceintheoralmucosa AT joselsancheztrincado immunetoleranceintheoralmucosa AT esthermlafuente immunetoleranceintheoralmucosa AT pedroareche immunetoleranceintheoralmucosa
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Immune Tolerance in the Oral Mucosa

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