Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation

Given combined efforts of neuroscience and immunology, increasing evidence has revealed the critical roles of the immune system in regulating homeostasis and disorders of the central nervous system (CNS). Microglia have long been considered as the only immune cell type in parenchyma, while at the in...

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Autores principales:	Liang Guo, Lingling Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	peripheral inflammation neuroinflammation brain-peripheral crosstalk hypobaric hypoxia ischemic hypoxia Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9e3c7f8c1f7f4e72ac8a0ae357664e17
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spelling	oai:doaj.org-article:9e3c7f8c1f7f4e72ac8a0ae357664e172021-11-22T04:55:52ZMultiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation2296-889X10.3389/fmolb.2021.752465https://doaj.org/article/9e3c7f8c1f7f4e72ac8a0ae357664e172021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.752465/fullhttps://doaj.org/toc/2296-889XGiven combined efforts of neuroscience and immunology, increasing evidence has revealed the critical roles of the immune system in regulating homeostasis and disorders of the central nervous system (CNS). Microglia have long been considered as the only immune cell type in parenchyma, while at the interface between CNS and the peripheral (meninges, choroid plexus, and perivascular space), embryonically originated border-associated macrophages (BAMs) and multiple surveilling leukocytes capable of migrating into and out of the brain have been identified to function in the healthy brain. Hypoxia-induced neuroinflammation is the key pathological procedure that can be detected in healthy people at high altitude or in various neurodegenerative diseases, during which a very thin line between a beneficial response of the peripheral immune system in maintaining brain homeostasis and a pathological role in exacerbating neuroinflammation has been revealed. Here, we are going to focus on the role of the peripheral immune system and its crosstalk with CNS in the healthy brain and especially in hypobaric or ischemic hypoxia-associated neuroinflammation.Liang GuoLingling ZhuLingling ZhuLingling ZhuFrontiers Media S.A.articleperipheral inflammationneuroinflammationbrain-peripheral crosstalkhypobaric hypoxiaischemic hypoxiaBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	peripheral inflammation neuroinflammation brain-peripheral crosstalk hypobaric hypoxia ischemic hypoxia Biology (General) QH301-705.5
spellingShingle	peripheral inflammation neuroinflammation brain-peripheral crosstalk hypobaric hypoxia ischemic hypoxia Biology (General) QH301-705.5 Liang Guo Lingling Zhu Lingling Zhu Lingling Zhu Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation
description	Given combined efforts of neuroscience and immunology, increasing evidence has revealed the critical roles of the immune system in regulating homeostasis and disorders of the central nervous system (CNS). Microglia have long been considered as the only immune cell type in parenchyma, while at the interface between CNS and the peripheral (meninges, choroid plexus, and perivascular space), embryonically originated border-associated macrophages (BAMs) and multiple surveilling leukocytes capable of migrating into and out of the brain have been identified to function in the healthy brain. Hypoxia-induced neuroinflammation is the key pathological procedure that can be detected in healthy people at high altitude or in various neurodegenerative diseases, during which a very thin line between a beneficial response of the peripheral immune system in maintaining brain homeostasis and a pathological role in exacerbating neuroinflammation has been revealed. Here, we are going to focus on the role of the peripheral immune system and its crosstalk with CNS in the healthy brain and especially in hypobaric or ischemic hypoxia-associated neuroinflammation.
format	article
author	Liang Guo Lingling Zhu Lingling Zhu Lingling Zhu
author_facet	Liang Guo Lingling Zhu Lingling Zhu Lingling Zhu
author_sort	Liang Guo
title	Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation
title_short	Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation
title_full	Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation
title_fullStr	Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation
title_full_unstemmed	Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation
title_sort	multiple roles of peripheral immune system in modulating ischemia/hypoxia-induced neuroinflammation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9e3c7f8c1f7f4e72ac8a0ae357664e17
work_keys_str_mv	AT liangguo multiplerolesofperipheralimmunesysteminmodulatingischemiahypoxiainducedneuroinflammation AT linglingzhu multiplerolesofperipheralimmunesysteminmodulatingischemiahypoxiainducedneuroinflammation AT linglingzhu multiplerolesofperipheralimmunesysteminmodulatingischemiahypoxiainducedneuroinflammation AT linglingzhu multiplerolesofperipheralimmunesysteminmodulatingischemiahypoxiainducedneuroinflammation
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Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation

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