BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis

c-MYC genomic distribution is dictated by the epigenetic context but the mechanisms are unknown. Here, the authors show that c-MYC requires the chromatin reader BPTF to activate its transcriptional program and promote tumour development in vivo, suggesting that BPTF is a potential target for cancer...

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Autores principales:	Laia Richart, Enrique Carrillo-de Santa Pau, Ana Río-Machín, Mónica P. de Andrés, Juan C. Cigudosa, Víctor J. Sánchez-Arévalo Lobo, Francisco X. Real
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e41642534ff4cecb91d4e1d757e9e25
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spelling	oai:doaj.org-article:9e41642534ff4cecb91d4e1d757e9e252021-12-02T14:39:51ZBPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis10.1038/ncomms101532041-1723https://doaj.org/article/9e41642534ff4cecb91d4e1d757e9e252016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10153https://doaj.org/toc/2041-1723c-MYC genomic distribution is dictated by the epigenetic context but the mechanisms are unknown. Here, the authors show that c-MYC requires the chromatin reader BPTF to activate its transcriptional program and promote tumour development in vivo, suggesting that BPTF is a potential target for cancer therapy.Laia RichartEnrique Carrillo-de Santa PauAna Río-MachínMónica P. de AndrésJuan C. CigudosaVíctor J. Sánchez-Arévalo LoboFrancisco X. RealNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laia Richart Enrique Carrillo-de Santa Pau Ana Río-Machín Mónica P. de Andrés Juan C. Cigudosa Víctor J. Sánchez-Arévalo Lobo Francisco X. Real BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
description	c-MYC genomic distribution is dictated by the epigenetic context but the mechanisms are unknown. Here, the authors show that c-MYC requires the chromatin reader BPTF to activate its transcriptional program and promote tumour development in vivo, suggesting that BPTF is a potential target for cancer therapy.
format	article
author	Laia Richart Enrique Carrillo-de Santa Pau Ana Río-Machín Mónica P. de Andrés Juan C. Cigudosa Víctor J. Sánchez-Arévalo Lobo Francisco X. Real
author_facet	Laia Richart Enrique Carrillo-de Santa Pau Ana Río-Machín Mónica P. de Andrés Juan C. Cigudosa Víctor J. Sánchez-Arévalo Lobo Francisco X. Real
author_sort	Laia Richart
title	BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
title_short	BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
title_full	BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
title_fullStr	BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
title_full_unstemmed	BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
title_sort	bptf is required for c-myc transcriptional activity and in vivo tumorigenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9e41642534ff4cecb91d4e1d757e9e25
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BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis

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