Diffusion microscopist simulator: a general Monte Carlo simulation system for diffusion magnetic resonance imaging.

This article describes the development and application of an integrated, generalized, and efficient Monte Carlo simulation system for diffusion magnetic resonance imaging (dMRI), named Diffusion Microscopist Simulator (DMS). DMS comprises a random walk Monte Carlo simulator and an MR image synthesiz...

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Autores principales:	Chun-Hung Yeh, Benoît Schmitt, Denis Le Bihan, Jing-Rebecca Li-Schlittgen, Ching-Po Lin, Cyril Poupon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e427a1f2a514c3d81ebbd5a7f2c6599
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spelling	oai:doaj.org-article:9e427a1f2a514c3d81ebbd5a7f2c65992021-11-18T08:51:38ZDiffusion microscopist simulator: a general Monte Carlo simulation system for diffusion magnetic resonance imaging.1932-620310.1371/journal.pone.0076626https://doaj.org/article/9e427a1f2a514c3d81ebbd5a7f2c65992013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24130783/?tool=EBIhttps://doaj.org/toc/1932-6203This article describes the development and application of an integrated, generalized, and efficient Monte Carlo simulation system for diffusion magnetic resonance imaging (dMRI), named Diffusion Microscopist Simulator (DMS). DMS comprises a random walk Monte Carlo simulator and an MR image synthesizer. The former has the capacity to perform large-scale simulations of Brownian dynamics in the virtual environments of neural tissues at various levels of complexity, and the latter is flexible enough to synthesize dMRI datasets from a variety of simulated MRI pulse sequences. The aims of DMS are to give insights into the link between the fundamental diffusion process in biological tissues and the features observed in dMRI, as well as to provide appropriate ground-truth information for the development, optimization, and validation of dMRI acquisition schemes for different applications. The validity, efficiency, and potential applications of DMS are evaluated through four benchmark experiments, including the simulated dMRI of white matter fibers, the multiple scattering diffusion imaging, the biophysical modeling of polar cell membranes, and the high angular resolution diffusion imaging and fiber tractography of complex fiber configurations. We expect that this novel software tool would be substantially advantageous to clarify the interrelationship between dMRI and the microscopic characteristics of brain tissues, and to advance the biophysical modeling and the dMRI methodologies.Chun-Hung YehBenoît SchmittDenis Le BihanJing-Rebecca Li-SchlittgenChing-Po LinCyril PouponPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e76626 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chun-Hung Yeh Benoît Schmitt Denis Le Bihan Jing-Rebecca Li-Schlittgen Ching-Po Lin Cyril Poupon Diffusion microscopist simulator: a general Monte Carlo simulation system for diffusion magnetic resonance imaging.
description	This article describes the development and application of an integrated, generalized, and efficient Monte Carlo simulation system for diffusion magnetic resonance imaging (dMRI), named Diffusion Microscopist Simulator (DMS). DMS comprises a random walk Monte Carlo simulator and an MR image synthesizer. The former has the capacity to perform large-scale simulations of Brownian dynamics in the virtual environments of neural tissues at various levels of complexity, and the latter is flexible enough to synthesize dMRI datasets from a variety of simulated MRI pulse sequences. The aims of DMS are to give insights into the link between the fundamental diffusion process in biological tissues and the features observed in dMRI, as well as to provide appropriate ground-truth information for the development, optimization, and validation of dMRI acquisition schemes for different applications. The validity, efficiency, and potential applications of DMS are evaluated through four benchmark experiments, including the simulated dMRI of white matter fibers, the multiple scattering diffusion imaging, the biophysical modeling of polar cell membranes, and the high angular resolution diffusion imaging and fiber tractography of complex fiber configurations. We expect that this novel software tool would be substantially advantageous to clarify the interrelationship between dMRI and the microscopic characteristics of brain tissues, and to advance the biophysical modeling and the dMRI methodologies.
format	article
author	Chun-Hung Yeh Benoît Schmitt Denis Le Bihan Jing-Rebecca Li-Schlittgen Ching-Po Lin Cyril Poupon
author_facet	Chun-Hung Yeh Benoît Schmitt Denis Le Bihan Jing-Rebecca Li-Schlittgen Ching-Po Lin Cyril Poupon
author_sort	Chun-Hung Yeh
title	Diffusion microscopist simulator: a general Monte Carlo simulation system for diffusion magnetic resonance imaging.
title_short	Diffusion microscopist simulator: a general Monte Carlo simulation system for diffusion magnetic resonance imaging.
title_full	Diffusion microscopist simulator: a general Monte Carlo simulation system for diffusion magnetic resonance imaging.
title_fullStr	Diffusion microscopist simulator: a general Monte Carlo simulation system for diffusion magnetic resonance imaging.
title_full_unstemmed	Diffusion microscopist simulator: a general Monte Carlo simulation system for diffusion magnetic resonance imaging.
title_sort	diffusion microscopist simulator: a general monte carlo simulation system for diffusion magnetic resonance imaging.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9e427a1f2a514c3d81ebbd5a7f2c6599
work_keys_str_mv	AT chunhungyeh diffusionmicroscopistsimulatorageneralmontecarlosimulationsystemfordiffusionmagneticresonanceimaging AT benoitschmitt diffusionmicroscopistsimulatorageneralmontecarlosimulationsystemfordiffusionmagneticresonanceimaging AT denislebihan diffusionmicroscopistsimulatorageneralmontecarlosimulationsystemfordiffusionmagneticresonanceimaging AT jingrebeccalischlittgen diffusionmicroscopistsimulatorageneralmontecarlosimulationsystemfordiffusionmagneticresonanceimaging AT chingpolin diffusionmicroscopistsimulatorageneralmontecarlosimulationsystemfordiffusionmagneticresonanceimaging AT cyrilpoupon diffusionmicroscopistsimulatorageneralmontecarlosimulationsystemfordiffusionmagneticresonanceimaging
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Diffusion microscopist simulator: a general Monte Carlo simulation system for diffusion magnetic resonance imaging.

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