Pulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.

<h4>Background</h4>Previous studies revealed that reduction of airway caliber in infancy might increase the risks for wheezing and asthma. However, the evidence for the predictive effects of pulmonary function on respiratory health in children was still inconsistent.<h4>Methods<...

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Autores principales:	Yungling Leo Lee, Bing-Fang Hwang, Yu-An Chen, Jer-Min Chen, Yi-Fan Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e43a20f01c94fca9c69903f17d77c50
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spelling	oai:doaj.org-article:9e43a20f01c94fca9c69903f17d77c502021-11-18T07:24:27ZPulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.1932-620310.1371/journal.pone.0032477https://doaj.org/article/9e43a20f01c94fca9c69903f17d77c502012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22457716/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Previous studies revealed that reduction of airway caliber in infancy might increase the risks for wheezing and asthma. However, the evidence for the predictive effects of pulmonary function on respiratory health in children was still inconsistent.<h4>Methods</h4>We conducted a population-based prospective cohort study among children in 14 Taiwanese communities. There were 3,160 children completed pulmonary function tests in 2007 and follow-up questionnaire in 2009. Poisson regression models were performed to estimate the effect of pulmonary function on the development of bronchitis and asthma.<h4>Results</h4>After adjustment for potential confounders, pulmonary function indices consistently showed protective effects on respiratory diseases in children. The incidence rate ratios of bronchitis and asthma were 0.86 (95% CI 0.79-0.95) and 0.91 (95% CI 0.82-0.99) for forced expiratory volume in 1 second (FEV₁). Similar adverse effects of maximal mid-expiratory flow (MMEF) were also observed on bronchitis (RR = 0.73, 95% CI 0.67-0.81) and asthma (RR = 0.85, 95% CI 0.77-0.93). We found significant decreasing trends in categorized FEV₁ (p for trend = 0.02) and categories of MMEF (p for trend = 0.01) for incident bronchitis. Significant modification effects of traffic-related air pollution were noted for FEV₁ and MMEF on bronchitis and also for MMEF on asthma.<h4>Conclusions</h4>Children with high pulmonary function would have lower risks on the development of bronchitis and asthma. The protective effect of high pulmonary function would be modified by traffic-related air pollution exposure.Yungling Leo LeeBing-Fang HwangYu-An ChenJer-Min ChenYi-Fan WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e32477 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yungling Leo Lee Bing-Fang Hwang Yu-An Chen Jer-Min Chen Yi-Fan Wu Pulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.
description	<h4>Background</h4>Previous studies revealed that reduction of airway caliber in infancy might increase the risks for wheezing and asthma. However, the evidence for the predictive effects of pulmonary function on respiratory health in children was still inconsistent.<h4>Methods</h4>We conducted a population-based prospective cohort study among children in 14 Taiwanese communities. There were 3,160 children completed pulmonary function tests in 2007 and follow-up questionnaire in 2009. Poisson regression models were performed to estimate the effect of pulmonary function on the development of bronchitis and asthma.<h4>Results</h4>After adjustment for potential confounders, pulmonary function indices consistently showed protective effects on respiratory diseases in children. The incidence rate ratios of bronchitis and asthma were 0.86 (95% CI 0.79-0.95) and 0.91 (95% CI 0.82-0.99) for forced expiratory volume in 1 second (FEV₁). Similar adverse effects of maximal mid-expiratory flow (MMEF) were also observed on bronchitis (RR = 0.73, 95% CI 0.67-0.81) and asthma (RR = 0.85, 95% CI 0.77-0.93). We found significant decreasing trends in categorized FEV₁ (p for trend = 0.02) and categories of MMEF (p for trend = 0.01) for incident bronchitis. Significant modification effects of traffic-related air pollution were noted for FEV₁ and MMEF on bronchitis and also for MMEF on asthma.<h4>Conclusions</h4>Children with high pulmonary function would have lower risks on the development of bronchitis and asthma. The protective effect of high pulmonary function would be modified by traffic-related air pollution exposure.
format	article
author	Yungling Leo Lee Bing-Fang Hwang Yu-An Chen Jer-Min Chen Yi-Fan Wu
author_facet	Yungling Leo Lee Bing-Fang Hwang Yu-An Chen Jer-Min Chen Yi-Fan Wu
author_sort	Yungling Leo Lee
title	Pulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.
title_short	Pulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.
title_full	Pulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.
title_fullStr	Pulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.
title_full_unstemmed	Pulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.
title_sort	pulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9e43a20f01c94fca9c69903f17d77c50
work_keys_str_mv	AT yunglingleolee pulmonaryfunctionandincidentbronchitisandasthmainchildrenacommunitybasedprospectivecohortstudy AT bingfanghwang pulmonaryfunctionandincidentbronchitisandasthmainchildrenacommunitybasedprospectivecohortstudy AT yuanchen pulmonaryfunctionandincidentbronchitisandasthmainchildrenacommunitybasedprospectivecohortstudy AT jerminchen pulmonaryfunctionandincidentbronchitisandasthmainchildrenacommunitybasedprospectivecohortstudy AT yifanwu pulmonaryfunctionandincidentbronchitisandasthmainchildrenacommunitybasedprospectivecohortstudy
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Pulmonary function and incident bronchitis and asthma in children: a community-based prospective cohort study.

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