Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease

Abstract Weight loss, the most established therapy for nonalcoholic fatty liver disease (NAFLD), is frequently followed by weight regain and fluctuation. The aim of this study was to investigate whether body weight change and variability were independent risk factors for incident NAFLD. We conducted...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eun Ju Cho, Su Jong Yu, Gu Cheol Jung, Min-Sun Kwak, Jong In Yang, Jeong Yoon Yim, Goh Eun Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e494caba5ea45a19d4186a2ea95dae4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e494caba5ea45a19d4186a2ea95dae4
record_format	dspace
spelling	oai:doaj.org-article:9e494caba5ea45a19d4186a2ea95dae42021-12-02T16:08:06ZBody weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease10.1038/s41598-021-93883-52045-2322https://doaj.org/article/9e494caba5ea45a19d4186a2ea95dae42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93883-5https://doaj.org/toc/2045-2322Abstract Weight loss, the most established therapy for nonalcoholic fatty liver disease (NAFLD), is frequently followed by weight regain and fluctuation. The aim of this study was to investigate whether body weight change and variability were independent risk factors for incident NAFLD. We conducted a longitudinal cohort study. Among the 1907 participants, incident NAFLD occurred in 420 (22.0%) cases during median follow-up of 5.6 years. In the multivariate analysis, there was no significant association between weight variability and the risk of incident NAFLD. The risk of incident NAFLD was significantly higher in subjects with weight gain ≥ 10% and 7% < gain ≤ 10% [hazard ratios (HR), 2.43; 95% confidence intervals (CI), 1.65–3.58 and HR, 1.73; 95% CI, 1.26–2.39, respectively], while the risk of incident NAFLD was significantly lower in those with −7% < weight loss ≤ -−3% (HR, 0.33; 95% CI, 0.22–0.51). Overall body weight gain rather than bodyweight variability was independently associated with the risk of incident NAFLD. Understanding the association between body weight variability and incident NAFLD may have future clinical implications for the quantification of weight loss as a treatment for patients with NAFLD.Eun Ju ChoSu Jong YuGu Cheol JungMin-Sun KwakJong In YangJeong Yoon YimGoh Eun ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eun Ju Cho Su Jong Yu Gu Cheol Jung Min-Sun Kwak Jong In Yang Jeong Yoon Yim Goh Eun Chung Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease
description	Abstract Weight loss, the most established therapy for nonalcoholic fatty liver disease (NAFLD), is frequently followed by weight regain and fluctuation. The aim of this study was to investigate whether body weight change and variability were independent risk factors for incident NAFLD. We conducted a longitudinal cohort study. Among the 1907 participants, incident NAFLD occurred in 420 (22.0%) cases during median follow-up of 5.6 years. In the multivariate analysis, there was no significant association between weight variability and the risk of incident NAFLD. The risk of incident NAFLD was significantly higher in subjects with weight gain ≥ 10% and 7% < gain ≤ 10% [hazard ratios (HR), 2.43; 95% confidence intervals (CI), 1.65–3.58 and HR, 1.73; 95% CI, 1.26–2.39, respectively], while the risk of incident NAFLD was significantly lower in those with −7% < weight loss ≤ -−3% (HR, 0.33; 95% CI, 0.22–0.51). Overall body weight gain rather than bodyweight variability was independently associated with the risk of incident NAFLD. Understanding the association between body weight variability and incident NAFLD may have future clinical implications for the quantification of weight loss as a treatment for patients with NAFLD.
format	article
author	Eun Ju Cho Su Jong Yu Gu Cheol Jung Min-Sun Kwak Jong In Yang Jeong Yoon Yim Goh Eun Chung
author_facet	Eun Ju Cho Su Jong Yu Gu Cheol Jung Min-Sun Kwak Jong In Yang Jeong Yoon Yim Goh Eun Chung
author_sort	Eun Ju Cho
title	Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease
title_short	Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease
title_full	Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease
title_fullStr	Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease
title_full_unstemmed	Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease
title_sort	body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e494caba5ea45a19d4186a2ea95dae4
work_keys_str_mv	AT eunjucho bodyweightgainratherthanbodyweightvariabilityassociatedwithincreasedriskofnonalcoholicfattyliverdisease AT sujongyu bodyweightgainratherthanbodyweightvariabilityassociatedwithincreasedriskofnonalcoholicfattyliverdisease AT gucheoljung bodyweightgainratherthanbodyweightvariabilityassociatedwithincreasedriskofnonalcoholicfattyliverdisease AT minsunkwak bodyweightgainratherthanbodyweightvariabilityassociatedwithincreasedriskofnonalcoholicfattyliverdisease AT jonginyang bodyweightgainratherthanbodyweightvariabilityassociatedwithincreasedriskofnonalcoholicfattyliverdisease AT jeongyoonyim bodyweightgainratherthanbodyweightvariabilityassociatedwithincreasedriskofnonalcoholicfattyliverdisease AT goheunchung bodyweightgainratherthanbodyweightvariabilityassociatedwithincreasedriskofnonalcoholicfattyliverdisease
_version_	1718384612861804544

Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease

Ejemplares similares