The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice

Abstract Hypercholesterolaemia is a major risk factor for cardiovascular disease and it has been found that some probiotic bacteria possess cholesterol-lowering capabilities. In this study, the ability of the Lab4 probiotic consortium to hydrolyse bile salts, assimilate cholesterol and regulate chol...

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Autores principales:	D. R. Michael, T. S. Davies, J. W. E. Moss, D. Lama Calvente, D. P. Ramji, J. R. Marchesi, A. Pechlivanis, S. F. Plummer, T. R. Hughes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e49a95073474e3cbe49125acb48e050
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spelling	oai:doaj.org-article:9e49a95073474e3cbe49125acb48e0502021-12-02T16:08:08ZThe anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice10.1038/s41598-017-02889-52045-2322https://doaj.org/article/9e49a95073474e3cbe49125acb48e0502017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02889-5https://doaj.org/toc/2045-2322Abstract Hypercholesterolaemia is a major risk factor for cardiovascular disease and it has been found that some probiotic bacteria possess cholesterol-lowering capabilities. In this study, the ability of the Lab4 probiotic consortium to hydrolyse bile salts, assimilate cholesterol and regulate cholesterol transport by polarised Caco-2 enterocytes was demonstrated. Furthermore, in wild-type C57BL/6J mice fed a high fat diet, 2-weeks supplementation with Lab4 probiotic consortium plus Lactobacillus plantarum CUL66 resulted in significant reductions in plasma total cholesterol levels and suppression of diet-induced weight gain. No changes in plasma levels of very low-density lipoprotein/low-density lipoprotein, high-density lipoprotein, triglycerides, cytokines or bile acids were observed. Increased amounts of total and unconjugated bile acids in the faeces of the probiotic-fed mice, together with modulation of hepatic small heterodimer partner and cholesterol-7α-hydroxylase mRNA expression, implicates bile salt hydrolase activity as a potential mechanism of action. In summary, this study demonstrates the cholesterol-lowering efficacy of short-term feeding of the Lab4 probiotic consortium plus L. plantarum CUL66 in wild-type mice and supports further assessment in human trials.D. R. MichaelT. S. DaviesJ. W. E. MossD. Lama CalventeD. P. RamjiJ. R. MarchesiA. PechlivanisS. F. PlummerT. R. HughesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. R. Michael T. S. Davies J. W. E. Moss D. Lama Calvente D. P. Ramji J. R. Marchesi A. Pechlivanis S. F. Plummer T. R. Hughes The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice
description	Abstract Hypercholesterolaemia is a major risk factor for cardiovascular disease and it has been found that some probiotic bacteria possess cholesterol-lowering capabilities. In this study, the ability of the Lab4 probiotic consortium to hydrolyse bile salts, assimilate cholesterol and regulate cholesterol transport by polarised Caco-2 enterocytes was demonstrated. Furthermore, in wild-type C57BL/6J mice fed a high fat diet, 2-weeks supplementation with Lab4 probiotic consortium plus Lactobacillus plantarum CUL66 resulted in significant reductions in plasma total cholesterol levels and suppression of diet-induced weight gain. No changes in plasma levels of very low-density lipoprotein/low-density lipoprotein, high-density lipoprotein, triglycerides, cytokines or bile acids were observed. Increased amounts of total and unconjugated bile acids in the faeces of the probiotic-fed mice, together with modulation of hepatic small heterodimer partner and cholesterol-7α-hydroxylase mRNA expression, implicates bile salt hydrolase activity as a potential mechanism of action. In summary, this study demonstrates the cholesterol-lowering efficacy of short-term feeding of the Lab4 probiotic consortium plus L. plantarum CUL66 in wild-type mice and supports further assessment in human trials.
format	article
author	D. R. Michael T. S. Davies J. W. E. Moss D. Lama Calvente D. P. Ramji J. R. Marchesi A. Pechlivanis S. F. Plummer T. R. Hughes
author_facet	D. R. Michael T. S. Davies J. W. E. Moss D. Lama Calvente D. P. Ramji J. R. Marchesi A. Pechlivanis S. F. Plummer T. R. Hughes
author_sort	D. R. Michael
title	The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice
title_short	The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice
title_full	The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice
title_fullStr	The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice
title_full_unstemmed	The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice
title_sort	anti-cholesterolaemic effect of a consortium of probiotics: an acute study in c57bl/6j mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9e49a95073474e3cbe49125acb48e050
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The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice

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