Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China

Meng-Qi Chen,1 Wen-Rui Shi,1 Hao-Yu Wang,2 Zhao Li,1 Xiao-Fan Guo,1 Ying-Xian Sun1 1Department of Cardiology, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Cardiology, Coronary Heart Disease Center, Fuwai Hospital, National Cen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chen MQ, Shi WR, Wang HY, Li Z, Guo XF, Sun YX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	interaction diabetes hypertension general obesity central obesity Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9e4b74dd2f12479196f0b5cb5fec1c59
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e4b74dd2f12479196f0b5cb5fec1c59
record_format	dspace
spelling	oai:doaj.org-article:9e4b74dd2f12479196f0b5cb5fec1c592021-12-02T14:20:31ZInteraction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China1178-7007https://doaj.org/article/9e4b74dd2f12479196f0b5cb5fec1c592021-03-01T00:00:00Zhttps://www.dovepress.com/interaction-of-general-or-central-obesity-and-hypertension-on-diabetes-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Meng-Qi Chen,1 Wen-Rui Shi,1 Hao-Yu Wang,2 Zhao Li,1 Xiao-Fan Guo,1 Ying-Xian Sun1 1Department of Cardiology, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Cardiology, Coronary Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100037, People’s Republic of ChinaCorrespondence: Ying-Xian SunDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing, North Street, Heping District, Shenyang, 110001, People’s Republic of ChinaEmail yxsun_cmu@outlook.comPurpose: Some studies have established an association between hypertension or obesity and the risk of diabetes. This study aimed to examine the interaction of hypertension and obesity on diabetes.Participants and Methods: The data of 11,731 Chinese men and women were analyzed from the 2012– 2013 Northeast China Rural Cardiovascular Health Study. The interaction was examined by both additive and multiplicative scales. General obesity was measured by body mass index (BMI); central obesity was defined by waist circumference (WC), waist-to-height ratio (WHtR) and waist-to-hip ratio (WHpR).Results: After controlling for potential confounders, the odds ratios for diabetes were 3.864 (3.205– 4.660), 4.500 (3.673– 5.514), 4.932 (3.888– 6.255) and 4.701 (3.817– 5.788) for the combinations of hypertension and BMI, WC, WHtR or WHpR, respectively, which had the highest risk of diabetes among the four combinations. Notwithstanding the multiplicative interactions showed statistically significant in all analyses, the results of additive interactions were not consistent, suggesting the diabetes risk from female BMI (relative excess risk due to interaction (RERI): 1.136, 95% CI: 0.127– 2.146, attributable proportion due to interaction (AP): 0.267, 95% CI: 0.057– 0.477, synergy index (S):1.536, 95% CI: 1.017– 2.321) or female WHpR (RERI: 1.076, 95% CI: 0.150– 2.002, AP:0.205, 95% CI: 0.037– 0.374, S:1.340, 95% CI: 1.012– 1.775) was additive to the risk from hypertension.Conclusion: The findings suggest that high BMI and high WHpR have synergistic interactions with hypertension on the risk of diabetes for females. The results of this study also suggest that BMI and WHpR, rather than WC, should be used for the diagnosis of metabolic syndrome in Chinese population.Keywords: interaction, diabetes, hypertension, general obesity, central obesityChen MQShi WRWang HYLi ZGuo XFSun YXDove Medical Pressarticleinteractiondiabeteshypertensiongeneral obesitycentral obesitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1061-1072 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interaction diabetes hypertension general obesity central obesity Specialties of internal medicine RC581-951
spellingShingle	interaction diabetes hypertension general obesity central obesity Specialties of internal medicine RC581-951 Chen MQ Shi WR Wang HY Li Z Guo XF Sun YX Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China
description	Meng-Qi Chen,1 Wen-Rui Shi,1 Hao-Yu Wang,2 Zhao Li,1 Xiao-Fan Guo,1 Ying-Xian Sun1 1Department of Cardiology, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Cardiology, Coronary Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100037, People’s Republic of ChinaCorrespondence: Ying-Xian SunDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing, North Street, Heping District, Shenyang, 110001, People’s Republic of ChinaEmail yxsun_cmu@outlook.comPurpose: Some studies have established an association between hypertension or obesity and the risk of diabetes. This study aimed to examine the interaction of hypertension and obesity on diabetes.Participants and Methods: The data of 11,731 Chinese men and women were analyzed from the 2012– 2013 Northeast China Rural Cardiovascular Health Study. The interaction was examined by both additive and multiplicative scales. General obesity was measured by body mass index (BMI); central obesity was defined by waist circumference (WC), waist-to-height ratio (WHtR) and waist-to-hip ratio (WHpR).Results: After controlling for potential confounders, the odds ratios for diabetes were 3.864 (3.205– 4.660), 4.500 (3.673– 5.514), 4.932 (3.888– 6.255) and 4.701 (3.817– 5.788) for the combinations of hypertension and BMI, WC, WHtR or WHpR, respectively, which had the highest risk of diabetes among the four combinations. Notwithstanding the multiplicative interactions showed statistically significant in all analyses, the results of additive interactions were not consistent, suggesting the diabetes risk from female BMI (relative excess risk due to interaction (RERI): 1.136, 95% CI: 0.127– 2.146, attributable proportion due to interaction (AP): 0.267, 95% CI: 0.057– 0.477, synergy index (S):1.536, 95% CI: 1.017– 2.321) or female WHpR (RERI: 1.076, 95% CI: 0.150– 2.002, AP:0.205, 95% CI: 0.037– 0.374, S:1.340, 95% CI: 1.012– 1.775) was additive to the risk from hypertension.Conclusion: The findings suggest that high BMI and high WHpR have synergistic interactions with hypertension on the risk of diabetes for females. The results of this study also suggest that BMI and WHpR, rather than WC, should be used for the diagnosis of metabolic syndrome in Chinese population.Keywords: interaction, diabetes, hypertension, general obesity, central obesity
format	article
author	Chen MQ Shi WR Wang HY Li Z Guo XF Sun YX
author_facet	Chen MQ Shi WR Wang HY Li Z Guo XF Sun YX
author_sort	Chen MQ
title	Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China
title_short	Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China
title_full	Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China
title_fullStr	Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China
title_full_unstemmed	Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China
title_sort	interaction of general or central obesity and hypertension on diabetes: sex-specific differences in a rural population in northeast china
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9e4b74dd2f12479196f0b5cb5fec1c59
work_keys_str_mv	AT chenmq interactionofgeneralorcentralobesityandhypertensionondiabetessexspecificdifferencesinaruralpopulationinnortheastchina AT shiwr interactionofgeneralorcentralobesityandhypertensionondiabetessexspecificdifferencesinaruralpopulationinnortheastchina AT wanghy interactionofgeneralorcentralobesityandhypertensionondiabetessexspecificdifferencesinaruralpopulationinnortheastchina AT liz interactionofgeneralorcentralobesityandhypertensionondiabetessexspecificdifferencesinaruralpopulationinnortheastchina AT guoxf interactionofgeneralorcentralobesityandhypertensionondiabetessexspecificdifferencesinaruralpopulationinnortheastchina AT sunyx interactionofgeneralorcentralobesityandhypertensionondiabetessexspecificdifferencesinaruralpopulationinnortheastchina
_version_	1718391564210798592

Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China

Ejemplares similares