Associations between human leukocyte antigens and renal function

Abstract Human leukocyte antigens (HLA) have been associated with renal function, but previous studies report contradictory findings with little consensus on the exact nature or impact of this observation. This study included 401,307 white British subjects aged 39–73 when they were recruited by UK B...

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Autores principales:	Marcus Lowe, Antony Payton, Arpana Verma, Judith Worthington, Isla Gemmell, Patrick Hamilton, William Ollier, Titus Augustine, Kay Poulton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e4bec67b54e4d8488a8d21324532617
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spelling	oai:doaj.org-article:9e4bec67b54e4d8488a8d213245326172021-12-02T14:06:57ZAssociations between human leukocyte antigens and renal function10.1038/s41598-021-82361-72045-2322https://doaj.org/article/9e4bec67b54e4d8488a8d213245326172021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82361-7https://doaj.org/toc/2045-2322Abstract Human leukocyte antigens (HLA) have been associated with renal function, but previous studies report contradictory findings with little consensus on the exact nature or impact of this observation. This study included 401,307 white British subjects aged 39–73 when they were recruited by UK Biobank. Subjects’ HLA types were imputed using HLAIMP:02 software. Regression analysis was used to compare 362 imputed HLA types with estimated glomerular filtration rate (eGFR) as a primary outcome and clinical indications as secondary outcome measures. 22 imputed HLA types were associated with increased eGFR (and therefore increased renal function). Decreased eGFR (decreased renal function) was associated with 11 imputed HLA types, seven of which were also associated with increased risk of end-stage renal disease and/or chronic kidney disease. Many of these HLA types are commonly inherited together in established haplotypes, for example: HLA-A01:01, B08:01, C07:01, DRB103:01, DQB102:01. This haplotype has a population frequency of 9.5% in England and each allele was associated with decreased renal function. 33 imputed HLA types were associated with kidney function in white British subjects. Linkage disequilibrium in HLA heritance suggests that this is not random and particularly affects carriers of established haplotypes. This could have important applications for the diagnosis and treatment of renal disease and global population health.Marcus LoweAntony PaytonArpana VermaJudith WorthingtonIsla GemmellPatrick HamiltonWilliam OllierTitus AugustineKay PoultonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcus Lowe Antony Payton Arpana Verma Judith Worthington Isla Gemmell Patrick Hamilton William Ollier Titus Augustine Kay Poulton Associations between human leukocyte antigens and renal function
description	Abstract Human leukocyte antigens (HLA) have been associated with renal function, but previous studies report contradictory findings with little consensus on the exact nature or impact of this observation. This study included 401,307 white British subjects aged 39–73 when they were recruited by UK Biobank. Subjects’ HLA types were imputed using HLAIMP:02 software. Regression analysis was used to compare 362 imputed HLA types with estimated glomerular filtration rate (eGFR) as a primary outcome and clinical indications as secondary outcome measures. 22 imputed HLA types were associated with increased eGFR (and therefore increased renal function). Decreased eGFR (decreased renal function) was associated with 11 imputed HLA types, seven of which were also associated with increased risk of end-stage renal disease and/or chronic kidney disease. Many of these HLA types are commonly inherited together in established haplotypes, for example: HLA-A01:01, B08:01, C07:01, DRB103:01, DQB102:01. This haplotype has a population frequency of 9.5% in England and each allele was associated with decreased renal function. 33 imputed HLA types were associated with kidney function in white British subjects. Linkage disequilibrium in HLA heritance suggests that this is not random and particularly affects carriers of established haplotypes. This could have important applications for the diagnosis and treatment of renal disease and global population health.
format	article
author	Marcus Lowe Antony Payton Arpana Verma Judith Worthington Isla Gemmell Patrick Hamilton William Ollier Titus Augustine Kay Poulton
author_facet	Marcus Lowe Antony Payton Arpana Verma Judith Worthington Isla Gemmell Patrick Hamilton William Ollier Titus Augustine Kay Poulton
author_sort	Marcus Lowe
title	Associations between human leukocyte antigens and renal function
title_short	Associations between human leukocyte antigens and renal function
title_full	Associations between human leukocyte antigens and renal function
title_fullStr	Associations between human leukocyte antigens and renal function
title_full_unstemmed	Associations between human leukocyte antigens and renal function
title_sort	associations between human leukocyte antigens and renal function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e4bec67b54e4d8488a8d21324532617
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Associations between human leukocyte antigens and renal function

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