Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.

Serotonin and its receptors (HTRs) play critical roles in brain development and in the regulation of cognition, mood, and anxiety. HTRs are highly expressed in human prefrontal cortex and exert control over prefrontal excitability. The serotonin system is a key treatment target for several psychiatr...

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Autores principales:	Evelyn K Lambe, Stu G Fillman, Maree J Webster, Cynthia Shannon Weickert
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e5429374df34e03a647171db14fe77e
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spelling	oai:doaj.org-article:9e5429374df34e03a647171db14fe77e2021-11-18T06:49:02ZSerotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.1932-620310.1371/journal.pone.0022799https://doaj.org/article/9e5429374df34e03a647171db14fe77e2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829518/?tool=EBIhttps://doaj.org/toc/1932-6203Serotonin and its receptors (HTRs) play critical roles in brain development and in the regulation of cognition, mood, and anxiety. HTRs are highly expressed in human prefrontal cortex and exert control over prefrontal excitability. The serotonin system is a key treatment target for several psychiatric disorders; however, the effectiveness of these drugs varies according to age. Despite strong evidence for developmental changes in prefrontal Htrs of rodents, the developmental regulation of HTR expression in human prefrontal cortex has not been examined. Using postmortem human prefrontal brain tissue from across postnatal life, we investigated the expression of key serotonin receptors with distinct inhibitory (HTR1A, HTR5A) and excitatory (HTR2A, HTR2C, HTR4, HTR6) effects on cortical neurons, including two receptors which appear to be expressed to a greater degree in inhibitory interneurons of cerebral cortex (HTR2C, HTR6). We found distinct developmental patterns of expression for each of these six HTRs, with profound changes in expression occurring early in postnatal development and also into adulthood. However, a collective look at these HTRs in terms of their likely neurophysiological effects and major cellular localization leads to a model that suggests developmental changes in expression of these individual HTRs may not perturb an overall balance between inhibitory and excitatory effects. Examining and understanding the healthy balance is critical to appreciate how abnormal expression of an individual HTR may create a window of vulnerability for the emergence of psychiatric illness.Evelyn K LambeStu G FillmanMaree J WebsterCynthia Shannon WeickertPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22799 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Evelyn K Lambe Stu G Fillman Maree J Webster Cynthia Shannon Weickert Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.
description	Serotonin and its receptors (HTRs) play critical roles in brain development and in the regulation of cognition, mood, and anxiety. HTRs are highly expressed in human prefrontal cortex and exert control over prefrontal excitability. The serotonin system is a key treatment target for several psychiatric disorders; however, the effectiveness of these drugs varies according to age. Despite strong evidence for developmental changes in prefrontal Htrs of rodents, the developmental regulation of HTR expression in human prefrontal cortex has not been examined. Using postmortem human prefrontal brain tissue from across postnatal life, we investigated the expression of key serotonin receptors with distinct inhibitory (HTR1A, HTR5A) and excitatory (HTR2A, HTR2C, HTR4, HTR6) effects on cortical neurons, including two receptors which appear to be expressed to a greater degree in inhibitory interneurons of cerebral cortex (HTR2C, HTR6). We found distinct developmental patterns of expression for each of these six HTRs, with profound changes in expression occurring early in postnatal development and also into adulthood. However, a collective look at these HTRs in terms of their likely neurophysiological effects and major cellular localization leads to a model that suggests developmental changes in expression of these individual HTRs may not perturb an overall balance between inhibitory and excitatory effects. Examining and understanding the healthy balance is critical to appreciate how abnormal expression of an individual HTR may create a window of vulnerability for the emergence of psychiatric illness.
format	article
author	Evelyn K Lambe Stu G Fillman Maree J Webster Cynthia Shannon Weickert
author_facet	Evelyn K Lambe Stu G Fillman Maree J Webster Cynthia Shannon Weickert
author_sort	Evelyn K Lambe
title	Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.
title_short	Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.
title_full	Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.
title_fullStr	Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.
title_full_unstemmed	Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.
title_sort	serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/9e5429374df34e03a647171db14fe77e
work_keys_str_mv	AT evelynklambe serotoninreceptorexpressioninhumanprefrontalcortexbalancingexcitationandinhibitionacrosspostnataldevelopment AT stugfillman serotoninreceptorexpressioninhumanprefrontalcortexbalancingexcitationandinhibitionacrosspostnataldevelopment AT mareejwebster serotoninreceptorexpressioninhumanprefrontalcortexbalancingexcitationandinhibitionacrosspostnataldevelopment AT cynthiashannonweickert serotoninreceptorexpressioninhumanprefrontalcortexbalancingexcitationandinhibitionacrosspostnataldevelopment
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Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.

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