COMPARING HEPATITIS B SEROPROTECTION IN PAKISTANI CHILDREN AT 5 AND 6 YEARS OF AGE AFTER EXPANDED PROGRAMME ON IMMUNIZATION (EPI) VACCINATION

Objective: To compare seroprotection of children at 5 and 6 year of age after receiving Hepatitis B vaccination according to Expanded Programme on Immunization (EPI). Study Design: Cross sectional study. Place and Duration of Study: The study was conducted in the Department of Paediatric Medic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ehsan Qadir, Qudratullah Malik, Muhammad Zahid, Ali Raza, Sajid Ali Shah, Syed Saddam Hussain
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	anti-hbs antibodies epi hepatitis b vaccination seroprotection Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9e54e632cd19493abba465bb9a8c76f6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e54e632cd19493abba465bb9a8c76f6
record_format	dspace
spelling	oai:doaj.org-article:9e54e632cd19493abba465bb9a8c76f62021-12-02T19:12:31ZCOMPARING HEPATITIS B SEROPROTECTION IN PAKISTANI CHILDREN AT 5 AND 6 YEARS OF AGE AFTER EXPANDED PROGRAMME ON IMMUNIZATION (EPI) VACCINATION0030-96482411-8842https://doaj.org/article/9e54e632cd19493abba465bb9a8c76f62020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5562https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare seroprotection of children at 5 and 6 year of age after receiving Hepatitis B vaccination according to Expanded Programme on Immunization (EPI). Study Design: Cross sectional study. Place and Duration of Study: The study was conducted in the Department of Paediatric Medicine, Pak Emirates Military Hospital, Rawalpindi, from Oct 2015 to Apr 2016. Methodology: After the approval of ethics committee, informed consent of participants was obtained. Total 85 children, both male and female, aging 5 and 6 years were included in study fulfilling inclusion criteria. 3.5 ml blood samples were obtained ensuring antiseptic precautions using disposable syringes. Samples were taken in vaccutainers, labeled with patient’s demographic information and were immediately transported to the Armed Forces Institute of Pathology (AFIP) for analysis. Hepatitis B surface antibody titers of >10 IU/ L was taken as protective and <10 IU/L were considered negative. Children with anti-HBs titer <10 IU/L were sent for revaccination. Data was analyzed using SPSS version 22. Results: Out of 85 children, 41 (48.2%) were female and 44 (51.8%) male. Mean anti hepatitis B antibodies levels was 92.15 ± 66.03 IU/L. There were 32 (74.4%) seroprotected children who have age of five years and there were 20 (47.6%) seroprotected children who were six years old. Conclusion: Our study concluded that with increasing age, significant number of children have decline in seroprotection against hepatitis B after receiving vaccination according to EPI schedule.Ehsan QadirQudratullah MalikMuhammad ZahidAli RazaSajid Ali ShahSyed Saddam HussainArmy Medical College Rawalpindiarticleanti-hbs antibodiesepihepatitis b vaccinationseroprotectionMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1349-1353 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-hbs antibodies epi hepatitis b vaccination seroprotection Medicine R Medicine (General) R5-920
spellingShingle	anti-hbs antibodies epi hepatitis b vaccination seroprotection Medicine R Medicine (General) R5-920 Ehsan Qadir Qudratullah Malik Muhammad Zahid Ali Raza Sajid Ali Shah Syed Saddam Hussain COMPARING HEPATITIS B SEROPROTECTION IN PAKISTANI CHILDREN AT 5 AND 6 YEARS OF AGE AFTER EXPANDED PROGRAMME ON IMMUNIZATION (EPI) VACCINATION
description	Objective: To compare seroprotection of children at 5 and 6 year of age after receiving Hepatitis B vaccination according to Expanded Programme on Immunization (EPI). Study Design: Cross sectional study. Place and Duration of Study: The study was conducted in the Department of Paediatric Medicine, Pak Emirates Military Hospital, Rawalpindi, from Oct 2015 to Apr 2016. Methodology: After the approval of ethics committee, informed consent of participants was obtained. Total 85 children, both male and female, aging 5 and 6 years were included in study fulfilling inclusion criteria. 3.5 ml blood samples were obtained ensuring antiseptic precautions using disposable syringes. Samples were taken in vaccutainers, labeled with patient’s demographic information and were immediately transported to the Armed Forces Institute of Pathology (AFIP) for analysis. Hepatitis B surface antibody titers of >10 IU/ L was taken as protective and <10 IU/L were considered negative. Children with anti-HBs titer <10 IU/L were sent for revaccination. Data was analyzed using SPSS version 22. Results: Out of 85 children, 41 (48.2%) were female and 44 (51.8%) male. Mean anti hepatitis B antibodies levels was 92.15 ± 66.03 IU/L. There were 32 (74.4%) seroprotected children who have age of five years and there were 20 (47.6%) seroprotected children who were six years old. Conclusion: Our study concluded that with increasing age, significant number of children have decline in seroprotection against hepatitis B after receiving vaccination according to EPI schedule.
format	article
author	Ehsan Qadir Qudratullah Malik Muhammad Zahid Ali Raza Sajid Ali Shah Syed Saddam Hussain
author_facet	Ehsan Qadir Qudratullah Malik Muhammad Zahid Ali Raza Sajid Ali Shah Syed Saddam Hussain
author_sort	Ehsan Qadir
title	COMPARING HEPATITIS B SEROPROTECTION IN PAKISTANI CHILDREN AT 5 AND 6 YEARS OF AGE AFTER EXPANDED PROGRAMME ON IMMUNIZATION (EPI) VACCINATION
title_short	COMPARING HEPATITIS B SEROPROTECTION IN PAKISTANI CHILDREN AT 5 AND 6 YEARS OF AGE AFTER EXPANDED PROGRAMME ON IMMUNIZATION (EPI) VACCINATION
title_full	COMPARING HEPATITIS B SEROPROTECTION IN PAKISTANI CHILDREN AT 5 AND 6 YEARS OF AGE AFTER EXPANDED PROGRAMME ON IMMUNIZATION (EPI) VACCINATION
title_fullStr	COMPARING HEPATITIS B SEROPROTECTION IN PAKISTANI CHILDREN AT 5 AND 6 YEARS OF AGE AFTER EXPANDED PROGRAMME ON IMMUNIZATION (EPI) VACCINATION
title_full_unstemmed	COMPARING HEPATITIS B SEROPROTECTION IN PAKISTANI CHILDREN AT 5 AND 6 YEARS OF AGE AFTER EXPANDED PROGRAMME ON IMMUNIZATION (EPI) VACCINATION
title_sort	comparing hepatitis b seroprotection in pakistani children at 5 and 6 years of age after expanded programme on immunization (epi) vaccination
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/9e54e632cd19493abba465bb9a8c76f6
work_keys_str_mv	AT ehsanqadir comparinghepatitisbseroprotectioninpakistanichildrenat5and6yearsofageafterexpandedprogrammeonimmunizationepivaccination AT qudratullahmalik comparinghepatitisbseroprotectioninpakistanichildrenat5and6yearsofageafterexpandedprogrammeonimmunizationepivaccination AT muhammadzahid comparinghepatitisbseroprotectioninpakistanichildrenat5and6yearsofageafterexpandedprogrammeonimmunizationepivaccination AT aliraza comparinghepatitisbseroprotectioninpakistanichildrenat5and6yearsofageafterexpandedprogrammeonimmunizationepivaccination AT sajidalishah comparinghepatitisbseroprotectioninpakistanichildrenat5and6yearsofageafterexpandedprogrammeonimmunizationepivaccination AT syedsaddamhussain comparinghepatitisbseroprotectioninpakistanichildrenat5and6yearsofageafterexpandedprogrammeonimmunizationepivaccination
_version_	1718377056996163584

COMPARING HEPATITIS B SEROPROTECTION IN PAKISTANI CHILDREN AT 5 AND 6 YEARS OF AGE AFTER EXPANDED PROGRAMME ON IMMUNIZATION (EPI) VACCINATION

Ejemplares similares