Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility

Jay T Guevarra, Robert Hiensch, Andrew W Varga, David M Rapoport Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai Integrative Sleep Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USACorrespondence: Jay T GuevarraDivision of Pulmonary, Critical Care, and Sle...

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Autores principales:	Guevarra JT, Hiensch R, Varga AW, Rapoport DM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	narcolepsy pitolisant histamine 3 receptor excessive daytime sleepiness cataplexy Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/9e56c7d5904649659b556f6c4e2f56f7
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spelling	oai:doaj.org-article:9e56c7d5904649659b556f6c4e2f56f72021-12-02T08:01:13ZPitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility1179-1608https://doaj.org/article/9e56c7d5904649659b556f6c4e2f56f72020-10-01T00:00:00Zhttps://www.dovepress.com/pitolisant-to-treat-excessive-daytime-sleepiness-and-cataplexy-in-adul-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Jay T Guevarra, Robert Hiensch, Andrew W Varga, David M Rapoport Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai Integrative Sleep Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USACorrespondence: Jay T GuevarraDivision of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai Integrative Sleep Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USATel +1 646 339-3862Fax +1 212 876 5519Email jay.guevarra@mountsinai.orgAbstract: Narcolepsy is a sleep disorder marked by chronic, debilitating excessive daytime sleepiness and can be associated with cataplexy, sleep paralysis and sleep-related hallucinations. Pharmacological therapy for narcolepsy primarily aims to increase wakefulness and reduce cataplexy attacks. Pitolisant is a first-in-class agent utilizing histamine to improve wakefulness by acting as an antagonist/inverse agonist of the presynaptic histamine 3 receptor. This review summarizes the clinical efficacy, safety and tolerability of pitolisant in treating the symptoms of narcolepsy. Randomized and observational studies demonstrate pitolisant to be effective in treating both hypersomnolence and cataplexy while generally being well tolerated at prescribed doses. The most common adverse reactions include headache, insomnia and nausea.Keywords: narcolepsy, pitolisant, histamine 3 receptor, excessive daytime sleepiness, cataplexyGuevarra JTHiensch RVarga AWRapoport DMDove Medical Pressarticlenarcolepsypitolisanthistamine 3 receptorexcessive daytime sleepinesscataplexyPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 709-719 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	narcolepsy pitolisant histamine 3 receptor excessive daytime sleepiness cataplexy Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	narcolepsy pitolisant histamine 3 receptor excessive daytime sleepiness cataplexy Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Guevarra JT Hiensch R Varga AW Rapoport DM Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility
description	Jay T Guevarra, Robert Hiensch, Andrew W Varga, David M Rapoport Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai Integrative Sleep Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USACorrespondence: Jay T GuevarraDivision of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai Integrative Sleep Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USATel +1 646 339-3862Fax +1 212 876 5519Email jay.guevarra@mountsinai.orgAbstract: Narcolepsy is a sleep disorder marked by chronic, debilitating excessive daytime sleepiness and can be associated with cataplexy, sleep paralysis and sleep-related hallucinations. Pharmacological therapy for narcolepsy primarily aims to increase wakefulness and reduce cataplexy attacks. Pitolisant is a first-in-class agent utilizing histamine to improve wakefulness by acting as an antagonist/inverse agonist of the presynaptic histamine 3 receptor. This review summarizes the clinical efficacy, safety and tolerability of pitolisant in treating the symptoms of narcolepsy. Randomized and observational studies demonstrate pitolisant to be effective in treating both hypersomnolence and cataplexy while generally being well tolerated at prescribed doses. The most common adverse reactions include headache, insomnia and nausea.Keywords: narcolepsy, pitolisant, histamine 3 receptor, excessive daytime sleepiness, cataplexy
format	article
author	Guevarra JT Hiensch R Varga AW Rapoport DM
author_facet	Guevarra JT Hiensch R Varga AW Rapoport DM
author_sort	Guevarra JT
title	Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility
title_short	Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility
title_full	Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility
title_fullStr	Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility
title_full_unstemmed	Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility
title_sort	pitolisant to treat excessive daytime sleepiness and cataplexy in adults with narcolepsy: rationale and clinical utility
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9e56c7d5904649659b556f6c4e2f56f7
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Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility

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