Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

Inflammatory responses determine the pathological course of spinal cord injury. Here, the authors report on pH responsive fibers for triggered release of IL-4 plasmid liposomes and sustained release of nerve growth factor to regulate the immune response and promote nerve regeneration to enhance func...

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Autores principales: Kun Xi, Yong Gu, Jincheng Tang, Hao Chen, Yun Xu, Liang Wu, Feng Cai, Lianfu Deng, Huilin Yang, Qin Shi, Wenguo Cui, Liang Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/9e599cdeffbb4b15b557c33380264a12
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spelling oai:doaj.org-article:9e599cdeffbb4b15b557c33380264a122021-12-02T17:41:08ZMicroenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery10.1038/s41467-020-18265-32041-1723https://doaj.org/article/9e599cdeffbb4b15b557c33380264a122020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18265-3https://doaj.org/toc/2041-1723Inflammatory responses determine the pathological course of spinal cord injury. Here, the authors report on pH responsive fibers for triggered release of IL-4 plasmid liposomes and sustained release of nerve growth factor to regulate the immune response and promote nerve regeneration to enhance functional recovery.Kun XiYong GuJincheng TangHao ChenYun XuLiang WuFeng CaiLianfu DengHuilin YangQin ShiWenguo CuiLiang ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kun Xi
Yong Gu
Jincheng Tang
Hao Chen
Yun Xu
Liang Wu
Feng Cai
Lianfu Deng
Huilin Yang
Qin Shi
Wenguo Cui
Liang Chen
Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery
description Inflammatory responses determine the pathological course of spinal cord injury. Here, the authors report on pH responsive fibers for triggered release of IL-4 plasmid liposomes and sustained release of nerve growth factor to regulate the immune response and promote nerve regeneration to enhance functional recovery.
format article
author Kun Xi
Yong Gu
Jincheng Tang
Hao Chen
Yun Xu
Liang Wu
Feng Cai
Lianfu Deng
Huilin Yang
Qin Shi
Wenguo Cui
Liang Chen
author_facet Kun Xi
Yong Gu
Jincheng Tang
Hao Chen
Yun Xu
Liang Wu
Feng Cai
Lianfu Deng
Huilin Yang
Qin Shi
Wenguo Cui
Liang Chen
author_sort Kun Xi
title Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery
title_short Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery
title_full Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery
title_fullStr Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery
title_full_unstemmed Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery
title_sort microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/9e599cdeffbb4b15b557c33380264a12
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AT yonggu microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT jinchengtang microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT haochen microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT yunxu microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT liangwu microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT fengcai microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT lianfudeng microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT huilinyang microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT qinshi microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT wenguocui microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
AT liangchen microenvironmentresponsiveimmunoregulatoryelectrospunfibersforpromotingnervefunctionrecovery
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