Flower buds like PVA/ZnO composite nanofibers assembly: Antibacterial, in vivo wound healing, cytotoxicity and histological studies

Poly vinyl alcohol (PVA) nanofibers incorporated with ZnO nanoparticles were successfully fabricated by electrospinning technique. The developed nanofibrous composites were characterized by structural and morphological analysis techniques including X-ray diffraction (XRD), fourier-transform infrared...

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Autores principales:	Mohammad Ali Norouzi, Majid Montazer, Tina Harifi, Pegah Karimi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	PVA/ZnO electrospun Nanofibers Antibacterial Cytotoxicity Wound healing Histological analysis Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/9e59cc39f0174dd682067eb8ff9d49b6
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spelling	oai:doaj.org-article:9e59cc39f0174dd682067eb8ff9d49b62021-11-24T04:24:13ZFlower buds like PVA/ZnO composite nanofibers assembly: Antibacterial, in vivo wound healing, cytotoxicity and histological studies0142-941810.1016/j.polymertesting.2020.106914https://doaj.org/article/9e59cc39f0174dd682067eb8ff9d49b62021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0142941820321437https://doaj.org/toc/0142-9418Poly vinyl alcohol (PVA) nanofibers incorporated with ZnO nanoparticles were successfully fabricated by electrospinning technique. The developed nanofibrous composites were characterized by structural and morphological analysis techniques including X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (FESEM). Good dispersion of the nanoparticles in the resultant nanofibers was observed and the incorporated nanoparticles of ZnO were in the shape of flower buds. Moreover, porosity and swelling properties of the prepared membranes were evaluated. Antibacterial, cytotoxicity assays as well as in-vivo wound healing experiments in mice were also studied. The minimum inhibitory concentration (MIC) of PVA/ZnO nanoparticles against S. aureus and E. coli was 250 and 62.5 μg/mL respectively, indicating the antibacterial activities of the nanocomposite fibers relating to the zinc oxide nanoparticles. In-vivo studies and higher values of transforming growth factor-β (TGF-β) further proved that PVA/ZnO composite nanofibers had accelerated wound healing properties. ZnO nanoparticles were responsible for the accelerated epithelial regeneration and better cell attachment based on the histological analysis.Mohammad Ali NorouziMajid MontazerTina HarifiPegah KarimiElsevierarticlePVA/ZnO electrospun NanofibersAntibacterialCytotoxicityWound healingHistological analysisPolymers and polymer manufactureTP1080-1185ENPolymer Testing, Vol 93, Iss , Pp 106914- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PVA/ZnO electrospun Nanofibers Antibacterial Cytotoxicity Wound healing Histological analysis Polymers and polymer manufacture TP1080-1185
spellingShingle	PVA/ZnO electrospun Nanofibers Antibacterial Cytotoxicity Wound healing Histological analysis Polymers and polymer manufacture TP1080-1185 Mohammad Ali Norouzi Majid Montazer Tina Harifi Pegah Karimi Flower buds like PVA/ZnO composite nanofibers assembly: Antibacterial, in vivo wound healing, cytotoxicity and histological studies
description	Poly vinyl alcohol (PVA) nanofibers incorporated with ZnO nanoparticles were successfully fabricated by electrospinning technique. The developed nanofibrous composites were characterized by structural and morphological analysis techniques including X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (FESEM). Good dispersion of the nanoparticles in the resultant nanofibers was observed and the incorporated nanoparticles of ZnO were in the shape of flower buds. Moreover, porosity and swelling properties of the prepared membranes were evaluated. Antibacterial, cytotoxicity assays as well as in-vivo wound healing experiments in mice were also studied. The minimum inhibitory concentration (MIC) of PVA/ZnO nanoparticles against S. aureus and E. coli was 250 and 62.5 μg/mL respectively, indicating the antibacterial activities of the nanocomposite fibers relating to the zinc oxide nanoparticles. In-vivo studies and higher values of transforming growth factor-β (TGF-β) further proved that PVA/ZnO composite nanofibers had accelerated wound healing properties. ZnO nanoparticles were responsible for the accelerated epithelial regeneration and better cell attachment based on the histological analysis.
format	article
author	Mohammad Ali Norouzi Majid Montazer Tina Harifi Pegah Karimi
author_facet	Mohammad Ali Norouzi Majid Montazer Tina Harifi Pegah Karimi
author_sort	Mohammad Ali Norouzi
title	Flower buds like PVA/ZnO composite nanofibers assembly: Antibacterial, in vivo wound healing, cytotoxicity and histological studies
title_short	Flower buds like PVA/ZnO composite nanofibers assembly: Antibacterial, in vivo wound healing, cytotoxicity and histological studies
title_full	Flower buds like PVA/ZnO composite nanofibers assembly: Antibacterial, in vivo wound healing, cytotoxicity and histological studies
title_fullStr	Flower buds like PVA/ZnO composite nanofibers assembly: Antibacterial, in vivo wound healing, cytotoxicity and histological studies
title_full_unstemmed	Flower buds like PVA/ZnO composite nanofibers assembly: Antibacterial, in vivo wound healing, cytotoxicity and histological studies
title_sort	flower buds like pva/zno composite nanofibers assembly: antibacterial, in vivo wound healing, cytotoxicity and histological studies
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9e59cc39f0174dd682067eb8ff9d49b6
work_keys_str_mv	AT mohammadalinorouzi flowerbudslikepvaznocompositenanofibersassemblyantibacterialinvivowoundhealingcytotoxicityandhistologicalstudies AT majidmontazer flowerbudslikepvaznocompositenanofibersassemblyantibacterialinvivowoundhealingcytotoxicityandhistologicalstudies AT tinaharifi flowerbudslikepvaznocompositenanofibersassemblyantibacterialinvivowoundhealingcytotoxicityandhistologicalstudies AT pegahkarimi flowerbudslikepvaznocompositenanofibersassemblyantibacterialinvivowoundhealingcytotoxicityandhistologicalstudies
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Flower buds like PVA/ZnO composite nanofibers assembly: Antibacterial, in vivo wound healing, cytotoxicity and histological studies

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