Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1

Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections. Here, we accessed samples from 153 pregnant women (77 without and 76 with CZS) and 143 newborns (77 without and 66 w...

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Autores principales:	Tamiris Azamor, Daniela Prado Cunha, Andréa Marques Vieira da Silva, Ohanna Cavalcanti de Lima Bezerra, Marcelo Ribeiro-Alves, Thyago Leal Calvo, Fernanda de Souza Gomes Kehdy, Fernanda Saloum de Neves Manta, Thiago Gomes de Toledo Pinto, Laís Pereira Ferreira, Elyzabeth Avvad Portari, Letícia da Cunha Guida, Leonardo Gomes, Maria Elisabeth Lopes Moreira, Elizeu Fagundes de Carvalho, Cynthia Chester Cardoso, Marcelo Muller, Ana Paula Dinis Ano Bom, Patrícia Cristina da Costa Neves, Zilton Vasconcelos, Milton Ozório Moraes
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Congenital Zika Syndrome rs2257167 placenta type I interferon type III interferon Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9e59da601860484194db897bc60c0cd0
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spelling	oai:doaj.org-article:9e59da601860484194db897bc60c0cd02021-12-01T03:00:51ZCongenital Zika Syndrome Is Associated With Interferon Alfa Receptor 11664-322410.3389/fimmu.2021.764746https://doaj.org/article/9e59da601860484194db897bc60c0cd02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.764746/fullhttps://doaj.org/toc/1664-3224Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections. Here, we accessed samples from 153 pregnant women (77 without and 76 with CZS) and 143 newborns (77 without and 66 with CZS) exposed to ZIKV conducted a case-control study to verify whether interferon alfa receptor 1 (IFNAR1) and interferon lambda 2 and 4 (IFNL2/4) single nucleotide polymorphisms (SNPs) contribute to CZS outcome, and characterized placenta gene expression profile at term. Newborns carrying CG/CC genotypes of rs2257167 in IFNAR1 presented higher risk of developing CZS (OR=3.41; IC=1.35-8.60; Pcorrected=0.032). No association between IFNL SNPs and CZS was observed. Placenta from CZS cases displayed lower levels of IFNL2 and ISG15 along with higher IFIT5. The rs2257167 CG/CC placentas also demonstrated high levels of IFIT5 and inflammation-related genes. We found CZS to be related with exacerbated type I IFN and insufficient type III IFN in placenta at term, forming an unbalanced response modulated by the IFNAR1 rs2257167 genotype. Despite of the low sample size se findings shed light on the host-pathogen interaction focusing on the genetically regulated type I/type III IFN axis that could lead to better management of Zika and other TORCH (Toxoplasma, Others, Rubella, Cytomegalovirus, Herpes) congenital infections.Tamiris AzamorTamiris AzamorDaniela Prado CunhaAndréa Marques Vieira da SilvaOhanna Cavalcanti de Lima BezerraMarcelo Ribeiro-AlvesThyago Leal CalvoFernanda de Souza Gomes KehdyFernanda Saloum de Neves MantaThiago Gomes de Toledo PintoLaís Pereira FerreiraElyzabeth Avvad PortariLetícia da Cunha GuidaLeonardo GomesMaria Elisabeth Lopes MoreiraElizeu Fagundes de CarvalhoCynthia Chester CardosoMarcelo MullerAna Paula Dinis Ano BomPatrícia Cristina da Costa NevesZilton VasconcelosMilton Ozório MoraesFrontiers Media S.A.articleCongenital Zika Syndromers2257167placentatype I interferontype III interferonImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Congenital Zika Syndrome rs2257167 placenta type I interferon type III interferon Immunologic diseases. Allergy RC581-607
spellingShingle	Congenital Zika Syndrome rs2257167 placenta type I interferon type III interferon Immunologic diseases. Allergy RC581-607 Tamiris Azamor Tamiris Azamor Daniela Prado Cunha Andréa Marques Vieira da Silva Ohanna Cavalcanti de Lima Bezerra Marcelo Ribeiro-Alves Thyago Leal Calvo Fernanda de Souza Gomes Kehdy Fernanda Saloum de Neves Manta Thiago Gomes de Toledo Pinto Laís Pereira Ferreira Elyzabeth Avvad Portari Letícia da Cunha Guida Leonardo Gomes Maria Elisabeth Lopes Moreira Elizeu Fagundes de Carvalho Cynthia Chester Cardoso Marcelo Muller Ana Paula Dinis Ano Bom Patrícia Cristina da Costa Neves Zilton Vasconcelos Milton Ozório Moraes Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1
description	Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections. Here, we accessed samples from 153 pregnant women (77 without and 76 with CZS) and 143 newborns (77 without and 66 with CZS) exposed to ZIKV conducted a case-control study to verify whether interferon alfa receptor 1 (IFNAR1) and interferon lambda 2 and 4 (IFNL2/4) single nucleotide polymorphisms (SNPs) contribute to CZS outcome, and characterized placenta gene expression profile at term. Newborns carrying CG/CC genotypes of rs2257167 in IFNAR1 presented higher risk of developing CZS (OR=3.41; IC=1.35-8.60; Pcorrected=0.032). No association between IFNL SNPs and CZS was observed. Placenta from CZS cases displayed lower levels of IFNL2 and ISG15 along with higher IFIT5. The rs2257167 CG/CC placentas also demonstrated high levels of IFIT5 and inflammation-related genes. We found CZS to be related with exacerbated type I IFN and insufficient type III IFN in placenta at term, forming an unbalanced response modulated by the IFNAR1 rs2257167 genotype. Despite of the low sample size se findings shed light on the host-pathogen interaction focusing on the genetically regulated type I/type III IFN axis that could lead to better management of Zika and other TORCH (Toxoplasma, Others, Rubella, Cytomegalovirus, Herpes) congenital infections.
format	article
author	Tamiris Azamor Tamiris Azamor Daniela Prado Cunha Andréa Marques Vieira da Silva Ohanna Cavalcanti de Lima Bezerra Marcelo Ribeiro-Alves Thyago Leal Calvo Fernanda de Souza Gomes Kehdy Fernanda Saloum de Neves Manta Thiago Gomes de Toledo Pinto Laís Pereira Ferreira Elyzabeth Avvad Portari Letícia da Cunha Guida Leonardo Gomes Maria Elisabeth Lopes Moreira Elizeu Fagundes de Carvalho Cynthia Chester Cardoso Marcelo Muller Ana Paula Dinis Ano Bom Patrícia Cristina da Costa Neves Zilton Vasconcelos Milton Ozório Moraes
author_facet	Tamiris Azamor Tamiris Azamor Daniela Prado Cunha Andréa Marques Vieira da Silva Ohanna Cavalcanti de Lima Bezerra Marcelo Ribeiro-Alves Thyago Leal Calvo Fernanda de Souza Gomes Kehdy Fernanda Saloum de Neves Manta Thiago Gomes de Toledo Pinto Laís Pereira Ferreira Elyzabeth Avvad Portari Letícia da Cunha Guida Leonardo Gomes Maria Elisabeth Lopes Moreira Elizeu Fagundes de Carvalho Cynthia Chester Cardoso Marcelo Muller Ana Paula Dinis Ano Bom Patrícia Cristina da Costa Neves Zilton Vasconcelos Milton Ozório Moraes
author_sort	Tamiris Azamor
title	Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1
title_short	Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1
title_full	Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1
title_fullStr	Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1
title_full_unstemmed	Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1
title_sort	congenital zika syndrome is associated with interferon alfa receptor 1
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9e59da601860484194db897bc60c0cd0
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Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1

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