Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid

ES Bronze-Uhle,1 BC Costa,1 VF Ximenes,2 PN Lisboa-Filho1 1Department of Physics, São Paulo State University (Unesp), School of Sciences, Bauru, São Paulo, Brazil; 2Department of Chemistry, São Paulo State University (Unesp), School of Sciences, Bauru, São...

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Autores principales:	Bronze-Uhle ES, Costa BC, Ximenes VF, Lisboa-Filho PN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Albumin nanoparticles drug delivery salicylic acid entrapped nano-carriers. Medical technology R855-855.5 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/9e5a023225eb46cca395abb60a115da1
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spelling	oai:doaj.org-article:9e5a023225eb46cca395abb60a115da12021-12-02T08:15:36ZSynthetic nanoparticles of bovine serum albumin with entrapped salicylic acid1177-8903https://doaj.org/article/9e5a023225eb46cca395abb60a115da12016-12-01T00:00:00Zhttps://www.dovepress.com/synthetic-nanoparticles-of-bovine-serum-albumin-with-entrapped-salicyl-peer-reviewed-article-NSAhttps://doaj.org/toc/1177-8903ES Bronze-Uhle,1 BC Costa,1 VF Ximenes,2 PN Lisboa-Filho1 1Department of Physics, São Paulo State University (Unesp), School of Sciences, Bauru, São Paulo, Brazil; 2Department of Chemistry, São Paulo State University (Unesp), School of Sciences, Bauru, São Paulo, Brazil Abstract: Bovine serum albumin (BSA) is highly water soluble and binds drugs or inorganic substances noncovalently for their effective delivery to various affected areas of the body. Due to the well-defined structure of the protein, containing charged amino acids, albumin nanoparticles (NPs) may allow electrostatic adsorption of negatively or positively charged molecules, such that substantial amounts of drug can be incorporated within the particle, due to different albumin-binding sites. During the synthesis procedure, pH changes significantly. This variation modifies the net charge on the surface of the protein, varying the size and behavior of NPs as the drug delivery system. In this study, the synthesis of BSA NPs, by a desolvation process, was studied with salicylic acid (SA) as the active agent. SA and salicylates are components of various plants and have been used for medication with anti-inflammatory, antibacterial, and antifungal properties. However, when administered orally to adults (usual dose provided by the manufacturer), there is 50% decomposition of salicylates. Thus, there has been a search for some time to develop new systems to improve the bioavailability of SA and salicylates in the human body. Taking this into account, during synthesis, the pH was varied (5.4, 7.4, and 9) to evaluate its influence on the size and release of SA of the formed NPs. The samples were analyzed using field-emission scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, zeta potential, and dynamic light scattering. Through fluorescence, it was possible to analyze the release of SA in vitro in phosphate-buffered saline solution. The results of chemical morphology characterization and in vitro release studies indicated the potential use of these NPs as drug carriers in biological systems requiring a fast release of SA. Keywords: albumin nanoparticles, drug delivery, salicylic acid entrapped, nano-carriersBronze-Uhle ESCosta BCXimenes VFLisboa-Filho PNDove Medical PressarticleAlbumin nanoparticlesdrug deliverysalicylic acid entrappednano-carriers.Medical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol Volume 10, Pp 11-21 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Albumin nanoparticles drug delivery salicylic acid entrapped nano-carriers. Medical technology R855-855.5 Chemical technology TP1-1185
spellingShingle	Albumin nanoparticles drug delivery salicylic acid entrapped nano-carriers. Medical technology R855-855.5 Chemical technology TP1-1185 Bronze-Uhle ES Costa BC Ximenes VF Lisboa-Filho PN Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid
description	ES Bronze-Uhle,1 BC Costa,1 VF Ximenes,2 PN Lisboa-Filho1 1Department of Physics, São Paulo State University (Unesp), School of Sciences, Bauru, São Paulo, Brazil; 2Department of Chemistry, São Paulo State University (Unesp), School of Sciences, Bauru, São Paulo, Brazil Abstract: Bovine serum albumin (BSA) is highly water soluble and binds drugs or inorganic substances noncovalently for their effective delivery to various affected areas of the body. Due to the well-defined structure of the protein, containing charged amino acids, albumin nanoparticles (NPs) may allow electrostatic adsorption of negatively or positively charged molecules, such that substantial amounts of drug can be incorporated within the particle, due to different albumin-binding sites. During the synthesis procedure, pH changes significantly. This variation modifies the net charge on the surface of the protein, varying the size and behavior of NPs as the drug delivery system. In this study, the synthesis of BSA NPs, by a desolvation process, was studied with salicylic acid (SA) as the active agent. SA and salicylates are components of various plants and have been used for medication with anti-inflammatory, antibacterial, and antifungal properties. However, when administered orally to adults (usual dose provided by the manufacturer), there is 50% decomposition of salicylates. Thus, there has been a search for some time to develop new systems to improve the bioavailability of SA and salicylates in the human body. Taking this into account, during synthesis, the pH was varied (5.4, 7.4, and 9) to evaluate its influence on the size and release of SA of the formed NPs. The samples were analyzed using field-emission scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, zeta potential, and dynamic light scattering. Through fluorescence, it was possible to analyze the release of SA in vitro in phosphate-buffered saline solution. The results of chemical morphology characterization and in vitro release studies indicated the potential use of these NPs as drug carriers in biological systems requiring a fast release of SA. Keywords: albumin nanoparticles, drug delivery, salicylic acid entrapped, nano-carriers
format	article
author	Bronze-Uhle ES Costa BC Ximenes VF Lisboa-Filho PN
author_facet	Bronze-Uhle ES Costa BC Ximenes VF Lisboa-Filho PN
author_sort	Bronze-Uhle ES
title	Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid
title_short	Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid
title_full	Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid
title_fullStr	Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid
title_full_unstemmed	Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid
title_sort	synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/9e5a023225eb46cca395abb60a115da1
work_keys_str_mv	AT bronzeuhlees syntheticnanoparticlesofbovineserumalbuminwithentrappedsalicylicacid AT costabc syntheticnanoparticlesofbovineserumalbuminwithentrappedsalicylicacid AT ximenesvf syntheticnanoparticlesofbovineserumalbuminwithentrappedsalicylicacid AT lisboafilhopn syntheticnanoparticlesofbovineserumalbuminwithentrappedsalicylicacid
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Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid

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