Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries

Background: Controlled hypotension is required for middle ear surgeries to achieve a bloodless operative field and improve its quality, both magnesium sulfate and nitroglycerine used to produce deliberate hypotension. Aim of the work: This study aimed to compare the efficacy of magnesium sulfate a...

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Autores principales:	Tawfik Noor El-Din, Mahmoud Madian, Eman Salem, Ahmed Hamed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	nitroglycerin magnesium sulphate hypotensive agents middle ear surgery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9e5c1aabc1284280a41c10689086fbf7
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spelling	oai:doaj.org-article:9e5c1aabc1284280a41c10689086fbf72021-12-02T15:22:19ZMagnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries2636-41742682-378010.21608/ijma.2020.23757.1098https://doaj.org/article/9e5c1aabc1284280a41c10689086fbf72020-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_100625_83faff5cbb13db8ce21f129b16c0e34b.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Controlled hypotension is required for middle ear surgeries to achieve a bloodless operative field and improve its quality, both magnesium sulfate and nitroglycerine used to produce deliberate hypotension. Aim of the work: This study aimed to compare the efficacy of magnesium sulfate and nitroglycerin in inducing controlled hypotensive anesthesia as a primary outcome and using propranolol if tachycardia occurred as a secondary outcome, in middle ear surgeries. Patients and Methods:The study was carried out on 40 adults’ patients were randomly classified into two equal groups, twenty patients each: Group [M]: Received an intravenous [IV] bolus of magnesium sulfate 30 mg/ kg in 100 ml saline over 10 min followed by infusion of 10 mg/kg/h. Group [N]: Received nitroglycerin IV infusion 0.5-10 mcg/kg/min. Propranolol 1- 2.5 mg IV had been given to both groups if there was tachycardia. Results: Both drugs induced hypotension with statistically significant difference in systolic and mean blood pressure [BP] and there was highly significant increase in heart rate [HR] in nitroglycerin more than magnesium sulfate and high doses of propranolol were administrated in nitroglycerine group. Postoperative pain was significantly increased in nitroglycerin than magnesium sulfate groups which had more analgesic effect. Conclusion: Both drugs induced hypotension. However, magnesium sulfate was better as it provided optimum surgical field, less tachycardia, need less dose of propranolol with less post-operative pain in comparison to nitroglycerinTawfik Noor El-DinMahmoud MadianEman SalemAhmed HamedAl-Azhar University, Faculty of Medicine (Damietta)articlenitroglycerinmagnesium sulphatehypotensive agentsmiddle earsurgeryMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 3, Pp 661-667 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nitroglycerin magnesium sulphate hypotensive agents middle ear surgery Medicine (General) R5-920
spellingShingle	nitroglycerin magnesium sulphate hypotensive agents middle ear surgery Medicine (General) R5-920 Tawfik Noor El-Din Mahmoud Madian Eman Salem Ahmed Hamed Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries
description	Background: Controlled hypotension is required for middle ear surgeries to achieve a bloodless operative field and improve its quality, both magnesium sulfate and nitroglycerine used to produce deliberate hypotension. Aim of the work: This study aimed to compare the efficacy of magnesium sulfate and nitroglycerin in inducing controlled hypotensive anesthesia as a primary outcome and using propranolol if tachycardia occurred as a secondary outcome, in middle ear surgeries. Patients and Methods:The study was carried out on 40 adults’ patients were randomly classified into two equal groups, twenty patients each: Group [M]: Received an intravenous [IV] bolus of magnesium sulfate 30 mg/ kg in 100 ml saline over 10 min followed by infusion of 10 mg/kg/h. Group [N]: Received nitroglycerin IV infusion 0.5-10 mcg/kg/min. Propranolol 1- 2.5 mg IV had been given to both groups if there was tachycardia. Results: Both drugs induced hypotension with statistically significant difference in systolic and mean blood pressure [BP] and there was highly significant increase in heart rate [HR] in nitroglycerin more than magnesium sulfate and high doses of propranolol were administrated in nitroglycerine group. Postoperative pain was significantly increased in nitroglycerin than magnesium sulfate groups which had more analgesic effect. Conclusion: Both drugs induced hypotension. However, magnesium sulfate was better as it provided optimum surgical field, less tachycardia, need less dose of propranolol with less post-operative pain in comparison to nitroglycerin
format	article
author	Tawfik Noor El-Din Mahmoud Madian Eman Salem Ahmed Hamed
author_facet	Tawfik Noor El-Din Mahmoud Madian Eman Salem Ahmed Hamed
author_sort	Tawfik Noor El-Din
title	Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries
title_short	Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries
title_full	Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries
title_fullStr	Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries
title_full_unstemmed	Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries
title_sort	magnesium sulfate versus nitroglycerin in controlled hypotensive anesthesia in middle ear surgeries
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/9e5c1aabc1284280a41c10689086fbf7
work_keys_str_mv	AT tawfiknooreldin magnesiumsulfateversusnitroglycerinincontrolledhypotensiveanesthesiainmiddleearsurgeries AT mahmoudmadian magnesiumsulfateversusnitroglycerinincontrolledhypotensiveanesthesiainmiddleearsurgeries AT emansalem magnesiumsulfateversusnitroglycerinincontrolledhypotensiveanesthesiainmiddleearsurgeries AT ahmedhamed magnesiumsulfateversusnitroglycerinincontrolledhypotensiveanesthesiainmiddleearsurgeries
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Magnesium Sulfate versus Nitroglycerin in Controlled Hypotensive Anesthesia in Middle Ear Surgeries

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