Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program

Over 100 million of opioid prescriptions are issued yearly in the USA alone, but the impact of opioid use on the immune system is barely characterized. Here the authors report antiviral immune response is blunted in several types of blood cells from opioid-dependent individuals, and when healthy don...

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Autores principales:	Tanya T. Karagiannis, John P. Cleary, Busra Gok, Andrew J. Henderson, Nicholas G. Martin, Masanao Yajima, Elliot C. Nelson, Christine S. Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e5ff00e7b874089bf331a67319d3183
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spelling	oai:doaj.org-article:9e5ff00e7b874089bf331a67319d31832021-12-02T16:53:16ZSingle cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program10.1038/s41467-020-16159-y2041-1723https://doaj.org/article/9e5ff00e7b874089bf331a67319d31832020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16159-yhttps://doaj.org/toc/2041-1723Over 100 million of opioid prescriptions are issued yearly in the USA alone, but the impact of opioid use on the immune system is barely characterized. Here the authors report antiviral immune response is blunted in several types of blood cells from opioid-dependent individuals, and when healthy donor cells are exposed to morphine in a dish.Tanya T. KaragiannisJohn P. ClearyBusra GokAndrew J. HendersonNicholas G. MartinMasanao YajimaElliot C. NelsonChristine S. ChengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tanya T. Karagiannis John P. Cleary Busra Gok Andrew J. Henderson Nicholas G. Martin Masanao Yajima Elliot C. Nelson Christine S. Cheng Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program
description	Over 100 million of opioid prescriptions are issued yearly in the USA alone, but the impact of opioid use on the immune system is barely characterized. Here the authors report antiviral immune response is blunted in several types of blood cells from opioid-dependent individuals, and when healthy donor cells are exposed to morphine in a dish.
format	article
author	Tanya T. Karagiannis John P. Cleary Busra Gok Andrew J. Henderson Nicholas G. Martin Masanao Yajima Elliot C. Nelson Christine S. Cheng
author_facet	Tanya T. Karagiannis John P. Cleary Busra Gok Andrew J. Henderson Nicholas G. Martin Masanao Yajima Elliot C. Nelson Christine S. Cheng
author_sort	Tanya T. Karagiannis
title	Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program
title_short	Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program
title_full	Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program
title_fullStr	Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program
title_full_unstemmed	Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program
title_sort	single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9e5ff00e7b874089bf331a67319d3183
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Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program

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