Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program
Over 100 million of opioid prescriptions are issued yearly in the USA alone, but the impact of opioid use on the immune system is barely characterized. Here the authors report antiviral immune response is blunted in several types of blood cells from opioid-dependent individuals, and when healthy don...
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Nature Portfolio
2020
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oai:doaj.org-article:9e5ff00e7b874089bf331a67319d31832021-12-02T16:53:16ZSingle cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program10.1038/s41467-020-16159-y2041-1723https://doaj.org/article/9e5ff00e7b874089bf331a67319d31832020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16159-yhttps://doaj.org/toc/2041-1723Over 100 million of opioid prescriptions are issued yearly in the USA alone, but the impact of opioid use on the immune system is barely characterized. Here the authors report antiviral immune response is blunted in several types of blood cells from opioid-dependent individuals, and when healthy donor cells are exposed to morphine in a dish.Tanya T. KaragiannisJohn P. ClearyBusra GokAndrew J. HendersonNicholas G. MartinMasanao YajimaElliot C. NelsonChristine S. ChengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
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Science Q Tanya T. Karagiannis John P. Cleary Busra Gok Andrew J. Henderson Nicholas G. Martin Masanao Yajima Elliot C. Nelson Christine S. Cheng Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program |
description |
Over 100 million of opioid prescriptions are issued yearly in the USA alone, but the impact of opioid use on the immune system is barely characterized. Here the authors report antiviral immune response is blunted in several types of blood cells from opioid-dependent individuals, and when healthy donor cells are exposed to morphine in a dish. |
format |
article |
author |
Tanya T. Karagiannis John P. Cleary Busra Gok Andrew J. Henderson Nicholas G. Martin Masanao Yajima Elliot C. Nelson Christine S. Cheng |
author_facet |
Tanya T. Karagiannis John P. Cleary Busra Gok Andrew J. Henderson Nicholas G. Martin Masanao Yajima Elliot C. Nelson Christine S. Cheng |
author_sort |
Tanya T. Karagiannis |
title |
Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program |
title_short |
Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program |
title_full |
Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program |
title_fullStr |
Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program |
title_full_unstemmed |
Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program |
title_sort |
single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/9e5ff00e7b874089bf331a67319d3183 |
work_keys_str_mv |
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