Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report

Epilepsy is a common and severe neurological disorder affecting millions of people worldwide. Nowadays, antiseizure medications (ASMs) are the main treatment for most epilepsy patients, although many of them do not respond to ASMs and suffer from drug-resistant epilepsy (DRE). Alternative and novel...

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Autores principales:	Georgios Mikellides, Panayiota Michael, Angelos Gregoriou, Teresa Schuhmann, Alexander T. Sack
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	epilepsy drug-resistant epilepsy orbitofrontal cortex repetitive transcranial magnetic stimulation Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9e605e839fdc43d19effb0ce807a3953
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spelling	oai:doaj.org-article:9e605e839fdc43d19effb0ce807a39532021-12-02T12:40:22ZBilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report1662-680X10.1159/000520257https://doaj.org/article/9e605e839fdc43d19effb0ce807a39532021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520257https://doaj.org/toc/1662-680XEpilepsy is a common and severe neurological disorder affecting millions of people worldwide. Nowadays, antiseizure medications (ASMs) are the main treatment for most epilepsy patients, although many of them do not respond to ASMs and suffer from drug-resistant epilepsy (DRE). Alternative and novel treatment methods have been offered nowadays, showing promising results for the treatment of DRE. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method that has become increasingly popular in the last decades. This article reports a patient with frontal lobe epilepsy. We aimed to investigate whether bilateral orbitofrontal (OFC) low-frequency rTMS (LF-rTMS) is feasible and tolerable, safe, and potentially clinically effective in treating epileptic seizures. The patient’s satisfaction with rTMS therapy was self-reported to be high, as rTMS helped in reducing the frequency of the focal attacks and completely abolished the preceding feeling of fear and panic. Therefore, bilateral OFC rTMS treatment can be well tolerated in patients with frontal epilepsy although the findings of the present case report with regard to clinical efficacy warrant further investigation.Georgios MikellidesPanayiota MichaelAngelos GregoriouTeresa SchuhmannAlexander T. SackKarger Publishersarticleepilepsydrug-resistant epilepsyorbitofrontal cortexrepetitive transcranial magnetic stimulationNeurology. Diseases of the nervous systemRC346-429ENCase Reports in Neurology, Vol 13, Iss 3, Pp 729-737 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epilepsy drug-resistant epilepsy orbitofrontal cortex repetitive transcranial magnetic stimulation Neurology. Diseases of the nervous system RC346-429
spellingShingle	epilepsy drug-resistant epilepsy orbitofrontal cortex repetitive transcranial magnetic stimulation Neurology. Diseases of the nervous system RC346-429 Georgios Mikellides Panayiota Michael Angelos Gregoriou Teresa Schuhmann Alexander T. Sack Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report
description	Epilepsy is a common and severe neurological disorder affecting millions of people worldwide. Nowadays, antiseizure medications (ASMs) are the main treatment for most epilepsy patients, although many of them do not respond to ASMs and suffer from drug-resistant epilepsy (DRE). Alternative and novel treatment methods have been offered nowadays, showing promising results for the treatment of DRE. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method that has become increasingly popular in the last decades. This article reports a patient with frontal lobe epilepsy. We aimed to investigate whether bilateral orbitofrontal (OFC) low-frequency rTMS (LF-rTMS) is feasible and tolerable, safe, and potentially clinically effective in treating epileptic seizures. The patient’s satisfaction with rTMS therapy was self-reported to be high, as rTMS helped in reducing the frequency of the focal attacks and completely abolished the preceding feeling of fear and panic. Therefore, bilateral OFC rTMS treatment can be well tolerated in patients with frontal epilepsy although the findings of the present case report with regard to clinical efficacy warrant further investigation.
format	article
author	Georgios Mikellides Panayiota Michael Angelos Gregoriou Teresa Schuhmann Alexander T. Sack
author_facet	Georgios Mikellides Panayiota Michael Angelos Gregoriou Teresa Schuhmann Alexander T. Sack
author_sort	Georgios Mikellides
title	Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report
title_short	Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report
title_full	Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report
title_fullStr	Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report
title_full_unstemmed	Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report
title_sort	bilateral orbitofrontal repetitive transcranial magnetic stimulation in frontal lobe epilepsy: a case report
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/9e605e839fdc43d19effb0ce807a3953
work_keys_str_mv	AT georgiosmikellides bilateralorbitofrontalrepetitivetranscranialmagneticstimulationinfrontallobeepilepsyacasereport AT panayiotamichael bilateralorbitofrontalrepetitivetranscranialmagneticstimulationinfrontallobeepilepsyacasereport AT angelosgregoriou bilateralorbitofrontalrepetitivetranscranialmagneticstimulationinfrontallobeepilepsyacasereport AT teresaschuhmann bilateralorbitofrontalrepetitivetranscranialmagneticstimulationinfrontallobeepilepsyacasereport AT alexandertsack bilateralorbitofrontalrepetitivetranscranialmagneticstimulationinfrontallobeepilepsyacasereport
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Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report

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