Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

Abstract Zika virus (ZIKV) has been extensively studied since it was linked to congenital malformations, and recent research has revealed that astrocytes are targets of ZIKV. However, the consequences of ZIKV infection, especially to this cell type, remain largely unknown, particularly considering i...

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Autores principales: Pítia Flores Ledur, Karina Karmirian, Carolina da Silva Gouveia Pedrosa, Leticia Rocha Quintino Souza, Gabriela Assis-de-Lemos, Thiago Martino Martins, Jéssica de Cassia Cavalheiro Gomes Ferreira, Gabriel Ferreira de Azevedo Reis, Eduardo Santos Silva, Débora Silva, José Alexandre Salerno, Isis Moraes Ornelas, Sylvie Devalle, Rodrigo Furtado Madeiro da Costa, Livia Goto-Silva, Luiza Mendonça Higa, Adriana Melo, Amilcar Tanuri, Leila Chimelli, Marcos Massao Murata, Patrícia Pestana Garcez, Eduardo Cremonese Filippi-Chiela, Antonio Galina, Helena Lobo Borges, Stevens Kastrup Rehen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9e62ed1ee57742299fe776937168f5bf
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