Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs

Dexmedetomidine is commonly used in small animal anesthesia for its potent sedative and analgesic properties; however, concerns regarding its cardiovascular effects prevent its full adoption into veterinary clinical practice. This meta-analysis was to determine the effects of dexmedetomidine on seda...

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Autores principales:	Shi-Yue Pan, Gang Liu, Jia-Hao Lin, Yi-Peng Jin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dexmedetomidine sedation and pain score hemodynamic effects dog meta-analysis Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/9e633e5ce820493dbd85f168e43ba626
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spelling	oai:doaj.org-article:9e633e5ce820493dbd85f168e43ba6262021-11-25T16:19:55ZEfficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs10.3390/ani111132542076-2615https://doaj.org/article/9e633e5ce820493dbd85f168e43ba6262021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3254https://doaj.org/toc/2076-2615Dexmedetomidine is commonly used in small animal anesthesia for its potent sedative and analgesic properties; however, concerns regarding its cardiovascular effects prevent its full adoption into veterinary clinical practice. This meta-analysis was to determine the effects of dexmedetomidine on sedation, analgesia, cardiovascular and adverse reactions in dogs compared to other premedications. Following the study protocol based on the Cochrane Review Methods, thirteen studies were included in this meta-analysis ultimately, involving a total of 576 dogs. Dexmedetomidine administration probably improved in sedation and analgesia in comparison to acepromazine, ketamine and lidocaine (MD: 1.96, 95% CI: [−0.08, 4.00], <i>p</i> = 0.06; MD: −0.95, 95% CI: [−1.52, −0.37] <i>p</i> = 0.001; respectively). Hemodynamic outcomes showed that dogs probably experienced lower heart rate and higher systolic arterial blood pressure and mean arterial blood pressure with dexmedetomidine at 30 min after premedication (MD: −13.25, 95% CI: [−19.67, −6.81], <i>p</i> < 0.0001; MD: 7.78, 95% CI: [1.83, 13.74], <i>p</i> = 0.01; MD: 8.32, 95% CI: [3.95, 12.70], <i>p</i> = 0.0002; respectively). The incidence of adverse effects was comparable between dexmedetomidine and other premedications (RR = 0.86, 95% CI [0.58, 1.29], <i>p</i> = 0.47). In summary, dexmedetomidine provides satisfactory sedative and analgesic effects, and its safety is proved despite its significant hemodynamic effects as part of balanced anesthesia of dogs.Shi-Yue PanGang LiuJia-Hao LinYi-Peng JinMDPI AGarticledexmedetomidinesedation and pain scorehemodynamic effectsdogmeta-analysisVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3254, p 3254 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dexmedetomidine sedation and pain score hemodynamic effects dog meta-analysis Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	dexmedetomidine sedation and pain score hemodynamic effects dog meta-analysis Veterinary medicine SF600-1100 Zoology QL1-991 Shi-Yue Pan Gang Liu Jia-Hao Lin Yi-Peng Jin Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs
description	Dexmedetomidine is commonly used in small animal anesthesia for its potent sedative and analgesic properties; however, concerns regarding its cardiovascular effects prevent its full adoption into veterinary clinical practice. This meta-analysis was to determine the effects of dexmedetomidine on sedation, analgesia, cardiovascular and adverse reactions in dogs compared to other premedications. Following the study protocol based on the Cochrane Review Methods, thirteen studies were included in this meta-analysis ultimately, involving a total of 576 dogs. Dexmedetomidine administration probably improved in sedation and analgesia in comparison to acepromazine, ketamine and lidocaine (MD: 1.96, 95% CI: [−0.08, 4.00], <i>p</i> = 0.06; MD: −0.95, 95% CI: [−1.52, −0.37] <i>p</i> = 0.001; respectively). Hemodynamic outcomes showed that dogs probably experienced lower heart rate and higher systolic arterial blood pressure and mean arterial blood pressure with dexmedetomidine at 30 min after premedication (MD: −13.25, 95% CI: [−19.67, −6.81], <i>p</i> < 0.0001; MD: 7.78, 95% CI: [1.83, 13.74], <i>p</i> = 0.01; MD: 8.32, 95% CI: [3.95, 12.70], <i>p</i> = 0.0002; respectively). The incidence of adverse effects was comparable between dexmedetomidine and other premedications (RR = 0.86, 95% CI [0.58, 1.29], <i>p</i> = 0.47). In summary, dexmedetomidine provides satisfactory sedative and analgesic effects, and its safety is proved despite its significant hemodynamic effects as part of balanced anesthesia of dogs.
format	article
author	Shi-Yue Pan Gang Liu Jia-Hao Lin Yi-Peng Jin
author_facet	Shi-Yue Pan Gang Liu Jia-Hao Lin Yi-Peng Jin
author_sort	Shi-Yue Pan
title	Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs
title_short	Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs
title_full	Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs
title_fullStr	Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs
title_full_unstemmed	Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs
title_sort	efficacy and safety of dexmedetomidine premedication in balanced anesthesia: a systematic review and meta-analysis in dogs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9e633e5ce820493dbd85f168e43ba626
work_keys_str_mv	AT shiyuepan efficacyandsafetyofdexmedetomidinepremedicationinbalancedanesthesiaasystematicreviewandmetaanalysisindogs AT gangliu efficacyandsafetyofdexmedetomidinepremedicationinbalancedanesthesiaasystematicreviewandmetaanalysisindogs AT jiahaolin efficacyandsafetyofdexmedetomidinepremedicationinbalancedanesthesiaasystematicreviewandmetaanalysisindogs AT yipengjin efficacyandsafetyofdexmedetomidinepremedicationinbalancedanesthesiaasystematicreviewandmetaanalysisindogs
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Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs

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