Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease

Abstract Evidence from several unrelated animal models and some studies conducted in humans, points to the immunomodulatory effects of androgens on various components of the immune system, especially on allergic disorders. This study evaluated the serum concentrations of sex hormones in women with a...

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Autores principales:	Violeta Lokaj-Berisha, Besa Gacaferri Lumezi, Naser Berisha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e6a2b64f29a479ebc7258728d16ebcc
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spelling	oai:doaj.org-article:9e6a2b64f29a479ebc7258728d16ebcc2021-12-02T13:34:57ZLow serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease10.1038/s41598-021-85214-52045-2322https://doaj.org/article/9e6a2b64f29a479ebc7258728d16ebcc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85214-5https://doaj.org/toc/2045-2322Abstract Evidence from several unrelated animal models and some studies conducted in humans, points to the immunomodulatory effects of androgens on various components of the immune system, especially on allergic disorders. This study evaluated the serum concentrations of sex hormones in women with allergy. For this purpose, blood samples were obtained from 78 participants in order to detect serum IgE concentrations, total testosterone, estradiol, progesterone, and DHEA-S. The majority of the subjects (54) in the study were consecutive patients with doctor-diagnosed allergic pathologies: 32 with allergic rhinitis, 10 with asthma and rhinitis, and 12 with skin allergies. In addition, 24 healthy volunteers were included in the research as the control group. The average age of the subjects was 32.54 years (SD ± 11.08 years, range between 4–59 years). All participants stated that they had not used any medical treatment to alleviate any of their symptoms prior to taking part in the research. They all underwent skin-prick tests for common aero-allergens, which was used as criterion for subject selection. Hence, the subjects were selected if they reacted positively to at least one aero-allergen. Their height and weight were measured in order to calculate the BMI. As a result, statistically significant differences between controls and allergic women in serum concentrations of androgens (testosterone, p = 0.0017; DHEA-S, p = 0.04) were found, which lead to the conclusion that the concentration of total serum testosterone and DHEA-S was lower in female patients with allergic diseases compared to controls.Violeta Lokaj-BerishaBesa Gacaferri LumeziNaser BerishaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Violeta Lokaj-Berisha Besa Gacaferri Lumezi Naser Berisha Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease
description	Abstract Evidence from several unrelated animal models and some studies conducted in humans, points to the immunomodulatory effects of androgens on various components of the immune system, especially on allergic disorders. This study evaluated the serum concentrations of sex hormones in women with allergy. For this purpose, blood samples were obtained from 78 participants in order to detect serum IgE concentrations, total testosterone, estradiol, progesterone, and DHEA-S. The majority of the subjects (54) in the study were consecutive patients with doctor-diagnosed allergic pathologies: 32 with allergic rhinitis, 10 with asthma and rhinitis, and 12 with skin allergies. In addition, 24 healthy volunteers were included in the research as the control group. The average age of the subjects was 32.54 years (SD ± 11.08 years, range between 4–59 years). All participants stated that they had not used any medical treatment to alleviate any of their symptoms prior to taking part in the research. They all underwent skin-prick tests for common aero-allergens, which was used as criterion for subject selection. Hence, the subjects were selected if they reacted positively to at least one aero-allergen. Their height and weight were measured in order to calculate the BMI. As a result, statistically significant differences between controls and allergic women in serum concentrations of androgens (testosterone, p = 0.0017; DHEA-S, p = 0.04) were found, which lead to the conclusion that the concentration of total serum testosterone and DHEA-S was lower in female patients with allergic diseases compared to controls.
format	article
author	Violeta Lokaj-Berisha Besa Gacaferri Lumezi Naser Berisha
author_facet	Violeta Lokaj-Berisha Besa Gacaferri Lumezi Naser Berisha
author_sort	Violeta Lokaj-Berisha
title	Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease
title_short	Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease
title_full	Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease
title_fullStr	Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease
title_full_unstemmed	Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease
title_sort	low serum levels of dehydroepiandrosterone sulfate and testosterone in albanian female patients with allergic disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e6a2b64f29a479ebc7258728d16ebcc
work_keys_str_mv	AT violetalokajberisha lowserumlevelsofdehydroepiandrosteronesulfateandtestosteroneinalbanianfemalepatientswithallergicdisease AT besagacaferrilumezi lowserumlevelsofdehydroepiandrosteronesulfateandtestosteroneinalbanianfemalepatientswithallergicdisease AT naserberisha lowserumlevelsofdehydroepiandrosteronesulfateandtestosteroneinalbanianfemalepatientswithallergicdisease
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Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease

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