Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

The effects of antibiotics on the gut microbiota can lead to enhanced colonization of Clostridioides difficile (C. difficile) and toxin-mediated pathogenesis. Here, using defined toxin-mutant strains and a murine model, the authors provide insights into how toxin-induced inflammation alters C. diffi...

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Autores principales:	Joshua R. Fletcher, Colleen M. Pike, Ruth J. Parsons, Alissa J. Rivera, Matthew H. Foley, Michael R. McLaren, Stephanie A. Montgomery, Casey M. Theriot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e6aa7aed98f489781f33be6a4d04611
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spelling	oai:doaj.org-article:9e6aa7aed98f489781f33be6a4d046112021-12-02T10:49:08ZClostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota10.1038/s41467-020-20746-42041-1723https://doaj.org/article/9e6aa7aed98f489781f33be6a4d046112021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20746-4https://doaj.org/toc/2041-1723The effects of antibiotics on the gut microbiota can lead to enhanced colonization of Clostridioides difficile (C. difficile) and toxin-mediated pathogenesis. Here, using defined toxin-mutant strains and a murine model, the authors provide insights into how toxin-induced inflammation alters C. difficile metabolism, host tissue gene expression and gut microbiota, together influencing a beneficial niche for infection.Joshua R. FletcherColleen M. PikeRuth J. ParsonsAlissa J. RiveraMatthew H. FoleyMichael R. McLarenStephanie A. MontgomeryCasey M. TheriotNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua R. Fletcher Colleen M. Pike Ruth J. Parsons Alissa J. Rivera Matthew H. Foley Michael R. McLaren Stephanie A. Montgomery Casey M. Theriot Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
description	The effects of antibiotics on the gut microbiota can lead to enhanced colonization of Clostridioides difficile (C. difficile) and toxin-mediated pathogenesis. Here, using defined toxin-mutant strains and a murine model, the authors provide insights into how toxin-induced inflammation alters C. difficile metabolism, host tissue gene expression and gut microbiota, together influencing a beneficial niche for infection.
format	article
author	Joshua R. Fletcher Colleen M. Pike Ruth J. Parsons Alissa J. Rivera Matthew H. Foley Michael R. McLaren Stephanie A. Montgomery Casey M. Theriot
author_facet	Joshua R. Fletcher Colleen M. Pike Ruth J. Parsons Alissa J. Rivera Matthew H. Foley Michael R. McLaren Stephanie A. Montgomery Casey M. Theriot
author_sort	Joshua R. Fletcher
title	Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
title_short	Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
title_full	Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
title_fullStr	Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
title_full_unstemmed	Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
title_sort	clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e6aa7aed98f489781f33be6a4d04611
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Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

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