Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing

Episodic memory requires associating items with temporal context, a process for which the medial temporal lobe (MTL) is critical. This study uses recordings from 27 human subjects who were undergoing surgical intervention for intractable epilepsy. These same data were also utilized in Umbach et al....

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Autores principales:	Hye Bin Yoo, Gray Umbach, Bradley Lega
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Episodic memory MTL Single unit Local field potential Temporal clustering Phase offset Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/9e6ab531548d49b6b6502130db06eb9f
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spelling	oai:doaj.org-article:9e6ab531548d49b6b6502130db06eb9f2021-11-10T04:21:11ZNeurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing1095-957210.1016/j.neuroimage.2021.118689https://doaj.org/article/9e6ab531548d49b6b6502130db06eb9f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921009629https://doaj.org/toc/1095-9572Episodic memory requires associating items with temporal context, a process for which the medial temporal lobe (MTL) is critical. This study uses recordings from 27 human subjects who were undergoing surgical intervention for intractable epilepsy. These same data were also utilized in Umbach et al. (2020). We identify 103 memory-sensitive neurons in the hippocampus and entorhinal cortex, whose firing rates predicted successful episodic memory encoding as subjects performed a verbal free recall task. These neurons exhibit important properties. First, as predicted from the temporal context model, they demonstrate reinstatement of firing patterns observed during encoding at the time of retrieval. The magnitude of reinstatement predicted the tendency of subjects to cluster retrieved memory items according to input serial position. Also, we found that spiking activity of these neurons was locked to the phase of hippocampal theta oscillations, but that the mean phase of spiking shifted between memory encoding versus retrieval. This unique observation is consistent with predictions of the “Separate Phases at Encoding And Retrieval (SPEAR)” model. Together, the properties we identify for memory-sensitive neurons characterize direct electrophysiological mechanisms for the representation of contextual information in the human MTL.Hye Bin YooGray UmbachBradley LegaElsevierarticleEpisodic memoryMTLSingle unitLocal field potentialTemporal clusteringPhase offsetNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118689- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Episodic memory MTL Single unit Local field potential Temporal clustering Phase offset Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Episodic memory MTL Single unit Local field potential Temporal clustering Phase offset Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Hye Bin Yoo Gray Umbach Bradley Lega Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing
description	Episodic memory requires associating items with temporal context, a process for which the medial temporal lobe (MTL) is critical. This study uses recordings from 27 human subjects who were undergoing surgical intervention for intractable epilepsy. These same data were also utilized in Umbach et al. (2020). We identify 103 memory-sensitive neurons in the hippocampus and entorhinal cortex, whose firing rates predicted successful episodic memory encoding as subjects performed a verbal free recall task. These neurons exhibit important properties. First, as predicted from the temporal context model, they demonstrate reinstatement of firing patterns observed during encoding at the time of retrieval. The magnitude of reinstatement predicted the tendency of subjects to cluster retrieved memory items according to input serial position. Also, we found that spiking activity of these neurons was locked to the phase of hippocampal theta oscillations, but that the mean phase of spiking shifted between memory encoding versus retrieval. This unique observation is consistent with predictions of the “Separate Phases at Encoding And Retrieval (SPEAR)” model. Together, the properties we identify for memory-sensitive neurons characterize direct electrophysiological mechanisms for the representation of contextual information in the human MTL.
format	article
author	Hye Bin Yoo Gray Umbach Bradley Lega
author_facet	Hye Bin Yoo Gray Umbach Bradley Lega
author_sort	Hye Bin Yoo
title	Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing
title_short	Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing
title_full	Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing
title_fullStr	Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing
title_full_unstemmed	Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing
title_sort	neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9e6ab531548d49b6b6502130db06eb9f
work_keys_str_mv	AT hyebinyoo neuronsinthehumanmedialtemporallobetrackmultipletemporalcontextsduringepisodicmemoryprocessing AT grayumbach neuronsinthehumanmedialtemporallobetrackmultipletemporalcontextsduringepisodicmemoryprocessing AT bradleylega neuronsinthehumanmedialtemporallobetrackmultipletemporalcontextsduringepisodicmemoryprocessing
_version_	1718440678204112896

Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing

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