Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography

Abstract Early diagnosis of ocular diseases improves the understanding of pathophysiology and aids in accurate monitoring and effective treatment. Advanced, multimodal ocular imaging platforms play a crucial role in visualization of ocular components and provide clinicians with a valuable tool for e...

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Autores principales:	Zohreh Hosseinaee, Nima Abbasi, Nicholas Pellegrino, Layla Khalili, Lyazzat Mukhangaliyeva, Parsin Haji Reza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e6c7897db7b4eebb911bfbac7df86b0
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spelling	oai:doaj.org-article:9e6c7897db7b4eebb911bfbac7df86b02021-12-02T17:51:13ZFunctional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography10.1038/s41598-021-90776-52045-2322https://doaj.org/article/9e6c7897db7b4eebb911bfbac7df86b02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90776-5https://doaj.org/toc/2045-2322Abstract Early diagnosis of ocular diseases improves the understanding of pathophysiology and aids in accurate monitoring and effective treatment. Advanced, multimodal ocular imaging platforms play a crucial role in visualization of ocular components and provide clinicians with a valuable tool for evaluating various eye diseases. Here, for the first time we present a non-contact, multiwavelength photoacoustic remote sensing (PARS) microscopy and swept-source optical coherence tomography (SS-OCT) for in-vivo functional and structural imaging of the eye. The system provides complementary imaging contrasts of optical absorption and optical scattering, and is used for simultaneous, non-contact, in-vivo imaging of murine eye. Results of vasculature and structural imaging as well as melanin content in the retinal pigment epithelium layer are presented. Multiwavelength PARS microscopy using Stimulated Raman scattering is applied to enable in-vivo, non-contact oxygen saturation estimation in the ocular tissue. The reported work may be a major step towards clinical translation of ophthalmic technologies and has the potential to advance the diagnosis and treatment of ocular diseases.Zohreh HosseinaeeNima AbbasiNicholas PellegrinoLayla KhaliliLyazzat MukhangaliyevaParsin Haji RezaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zohreh Hosseinaee Nima Abbasi Nicholas Pellegrino Layla Khalili Lyazzat Mukhangaliyeva Parsin Haji Reza Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography
description	Abstract Early diagnosis of ocular diseases improves the understanding of pathophysiology and aids in accurate monitoring and effective treatment. Advanced, multimodal ocular imaging platforms play a crucial role in visualization of ocular components and provide clinicians with a valuable tool for evaluating various eye diseases. Here, for the first time we present a non-contact, multiwavelength photoacoustic remote sensing (PARS) microscopy and swept-source optical coherence tomography (SS-OCT) for in-vivo functional and structural imaging of the eye. The system provides complementary imaging contrasts of optical absorption and optical scattering, and is used for simultaneous, non-contact, in-vivo imaging of murine eye. Results of vasculature and structural imaging as well as melanin content in the retinal pigment epithelium layer are presented. Multiwavelength PARS microscopy using Stimulated Raman scattering is applied to enable in-vivo, non-contact oxygen saturation estimation in the ocular tissue. The reported work may be a major step towards clinical translation of ophthalmic technologies and has the potential to advance the diagnosis and treatment of ocular diseases.
format	article
author	Zohreh Hosseinaee Nima Abbasi Nicholas Pellegrino Layla Khalili Lyazzat Mukhangaliyeva Parsin Haji Reza
author_facet	Zohreh Hosseinaee Nima Abbasi Nicholas Pellegrino Layla Khalili Lyazzat Mukhangaliyeva Parsin Haji Reza
author_sort	Zohreh Hosseinaee
title	Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography
title_short	Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography
title_full	Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography
title_fullStr	Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography
title_full_unstemmed	Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography
title_sort	functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e6c7897db7b4eebb911bfbac7df86b0
work_keys_str_mv	AT zohrehhosseinaee functionalandstructuralophthalmicimagingusingnoncontactmultimodalphotoacousticremotesensingmicroscopyandopticalcoherencetomography AT nimaabbasi functionalandstructuralophthalmicimagingusingnoncontactmultimodalphotoacousticremotesensingmicroscopyandopticalcoherencetomography AT nicholaspellegrino functionalandstructuralophthalmicimagingusingnoncontactmultimodalphotoacousticremotesensingmicroscopyandopticalcoherencetomography AT laylakhalili functionalandstructuralophthalmicimagingusingnoncontactmultimodalphotoacousticremotesensingmicroscopyandopticalcoherencetomography AT lyazzatmukhangaliyeva functionalandstructuralophthalmicimagingusingnoncontactmultimodalphotoacousticremotesensingmicroscopyandopticalcoherencetomography AT parsinhajireza functionalandstructuralophthalmicimagingusingnoncontactmultimodalphotoacousticremotesensingmicroscopyandopticalcoherencetomography
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Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography

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