Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus

SU Ogbonna,1 IU Ezeani,1 CI Okafor,2 S Chinenye31Department of Internal Medicine, Federal Medical Center, Umuahia, Abia State, Nigeria; 2Department of Internal Medicine, University of Nigeria Teaching Hospital, Enugu, Enugu State, Nigeria; 3Department of Internal Medicine, University of Port Harcour...

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Autores principales:	Ogbonna SU, Ezeani IU, Okafor CI, Chinenye S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Thyroid dysfunction type 2 diabetes mellitus hypothyroidism South east Nigeria relationship glycaemic status. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9e6d27bea42c4146a19e38bc0e409b1d
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spelling	oai:doaj.org-article:9e6d27bea42c4146a19e38bc0e409b1d2021-12-02T06:48:04ZAssociation between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus1178-7007https://doaj.org/article/9e6d27bea42c4146a19e38bc0e409b1d2019-07-01T00:00:00Zhttps://www.dovepress.com/association-between-glycemic-status-and-thyroid-dysfunction-in-patient-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007SU Ogbonna,1 IU Ezeani,1 CI Okafor,2 S Chinenye31Department of Internal Medicine, Federal Medical Center, Umuahia, Abia State, Nigeria; 2Department of Internal Medicine, University of Nigeria Teaching Hospital, Enugu, Enugu State, Nigeria; 3Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, NigeriaBackground: Thyroid dysfunction has been widely reported to be more common in patients with type 2 diabetes mellitus (T2DM) in various parts of the world; however, there is paucity of data on this in our environment.Objective: The aim of this study was to determine the possible relationship between glycemic status and thyroid dysfunction.Methodology: A total of 354 T2DM patients and 118 non-diabetic persons (controls) were recruited for the study. A pretested questionnaire was filled for each subject after due explanations. Their blood samples were tested for HbA1c, fT3, fT4, and TSH. Information retrieved from patient’s medical records included age at diagnosis of diabetes (DM) and duration of DM. Testing statistics done included Student’s t-test, chi square test, and regression analysis. P-value of less than 0.05 was taken to be statistically significant.Results: The results show that 43.5% and 37.3% of T2DM and control subjects, respectively, were males. Mean HbA1c was significantly higher in T2DM patients than in the controls (7.8±2.0% vs 5.8±1.2%, p=0.001), while mean fT3 was significantly lower in T2DM patients than in the controls (2.3±1.5 pg/mL vs 2.7±2.2 pg/mL, p=0.03). Mean HbA1c was significantly higher in T2DM patients with thyroid dysfunction compared to their euthyroid counterparts (8.1±1.9% vs 5.1±1.2%, p=0.001). HbA1c had a positive linear relationship with the presence of thyroid dysfunction (regression coefficient=1.89, p=0.001).Conclusion: There was a positive linear relationship between HbA1c and the presence of thyroid dysfunction in the T2DM patients in this study. There was an inverse relationship between HbA1c and serum fT3.Keywords: thyroid dysfunction, type 2 diabetes mellitus, hypothyroidism, South East Nigeria, relationship, glycemic statusOgbonna SUEzeani IUOkafor CIChinenye SDove Medical PressarticleThyroid dysfunctiontype 2 diabetes mellitushypothyroidismSouth east Nigeriarelationshipglycaemic status.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1113-1122 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Thyroid dysfunction type 2 diabetes mellitus hypothyroidism South east Nigeria relationship glycaemic status. Specialties of internal medicine RC581-951
spellingShingle	Thyroid dysfunction type 2 diabetes mellitus hypothyroidism South east Nigeria relationship glycaemic status. Specialties of internal medicine RC581-951 Ogbonna SU Ezeani IU Okafor CI Chinenye S Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
description	SU Ogbonna,1 IU Ezeani,1 CI Okafor,2 S Chinenye31Department of Internal Medicine, Federal Medical Center, Umuahia, Abia State, Nigeria; 2Department of Internal Medicine, University of Nigeria Teaching Hospital, Enugu, Enugu State, Nigeria; 3Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, NigeriaBackground: Thyroid dysfunction has been widely reported to be more common in patients with type 2 diabetes mellitus (T2DM) in various parts of the world; however, there is paucity of data on this in our environment.Objective: The aim of this study was to determine the possible relationship between glycemic status and thyroid dysfunction.Methodology: A total of 354 T2DM patients and 118 non-diabetic persons (controls) were recruited for the study. A pretested questionnaire was filled for each subject after due explanations. Their blood samples were tested for HbA1c, fT3, fT4, and TSH. Information retrieved from patient’s medical records included age at diagnosis of diabetes (DM) and duration of DM. Testing statistics done included Student’s t-test, chi square test, and regression analysis. P-value of less than 0.05 was taken to be statistically significant.Results: The results show that 43.5% and 37.3% of T2DM and control subjects, respectively, were males. Mean HbA1c was significantly higher in T2DM patients than in the controls (7.8±2.0% vs 5.8±1.2%, p=0.001), while mean fT3 was significantly lower in T2DM patients than in the controls (2.3±1.5 pg/mL vs 2.7±2.2 pg/mL, p=0.03). Mean HbA1c was significantly higher in T2DM patients with thyroid dysfunction compared to their euthyroid counterparts (8.1±1.9% vs 5.1±1.2%, p=0.001). HbA1c had a positive linear relationship with the presence of thyroid dysfunction (regression coefficient=1.89, p=0.001).Conclusion: There was a positive linear relationship between HbA1c and the presence of thyroid dysfunction in the T2DM patients in this study. There was an inverse relationship between HbA1c and serum fT3.Keywords: thyroid dysfunction, type 2 diabetes mellitus, hypothyroidism, South East Nigeria, relationship, glycemic status
format	article
author	Ogbonna SU Ezeani IU Okafor CI Chinenye S
author_facet	Ogbonna SU Ezeani IU Okafor CI Chinenye S
author_sort	Ogbonna SU
title	Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_short	Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_full	Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_fullStr	Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_full_unstemmed	Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
title_sort	association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9e6d27bea42c4146a19e38bc0e409b1d
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Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus

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