Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study

Adisu Birhanu Weldesenbet,1 Tadesse Awoke Ayele,2 Malede Mequanent Sisay,2 Biruk Shalmeno Tusa,1 Sewnet Adem Kebede2 1Department of Epidemiology and Biostatistics, College of Health and Medical Sciences, Haramaya University, Haramaya, Ethiopia; 2Department of Epidemiology and Biostatistics, Institut...

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Autores principales: Weldesenbet AB, Ayele TA, Sisay MM, Tusa BS, Kebede SA
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Lenguaje:EN
Publicado: Dove Medical Press 2020
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spelling oai:doaj.org-article:9e6de74945dd4701bae1c27a9bd32fe92021-12-02T12:57:14ZPredictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study1179-1373https://doaj.org/article/9e6de74945dd4701bae1c27a9bd32fe92020-08-01T00:00:00Zhttps://www.dovepress.com/predictors-of-change-in-weight-among-people-living-with-hiv-on-antiret-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Adisu Birhanu Weldesenbet,1 Tadesse Awoke Ayele,2 Malede Mequanent Sisay,2 Biruk Shalmeno Tusa,1 Sewnet Adem Kebede2 1Department of Epidemiology and Biostatistics, College of Health and Medical Sciences, Haramaya University, Haramaya, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Adisu Birhanu Weldesenbet Tel +251968295598Email adisuebi2009@gmail.comBackground: Human immunodeficiency virus (HIV) remains a major global public health issue, particularly in Africa. In resource-limited settings like Ethiopia, regular weight measurement and monitoring is useful in the examination of patient response to antiretroviral therapy and in clinical decision-making. However, there is a paucity of evidence on factors that affect longitudinal weight change. Therefore, the present study was intended to identify predictors of weight change among people living with HIV (PLWH) in West Hararghe, Ethiopia.Methods: An institutional-based retrospective cohort study was conducted among 558 PLWH aged 18 years and above from September 2013 to January 2019 at Chiro Zonal Hospital and Gelemso General Hospital in West Hararghe zone, Ethiopia. Data were entered in Epi info 7 and analyzed in R software. The linear mixed effect regression model was used to identify predictors of longitudinal change in weight. Regression coefficients with their 95% confidence intervals were used to indicate the strength and significance of the association.Results: Weight showed improvement in follow-up periods. In this study, age of respondent (beta=0.136, 95% CI, 0.044:0.227), time since the initiation of antiretroviral therapy (ART) (beta=0.089, 95% CI, 0.075:0.104), primary educational status (beta=2.403, 95% CI, 0.540:4.266), secondary educational status (beta=4.035, 95% CI, 1.666:6.404), tertiary and above educational status (beta=3.444, 95% CI, 0.330:6.558), sex (beta= − 5.514, 95% CI, -7.260:-3.768), ambulatory functional status (beta= − 3.419, 95% CI, − 6.169:-0.668) and baseline CD4 count (≤ 200) (beta=2.205, 95% CI, 0.593, 3.817) were significant predictors of longitudinal weight change.Conclusion: We observed an increment in weight among PLWH who were on ART in Ethiopia. Educational status, time since the beginning of ART, age and having CD4 count above 200 have contributed positively to the change in weight, while ambulatory functional status and being female are negatively associated with longitudinal change in weight. Close monitoring is recommended for patients with ambulatory baseline functional status and for patients with baseline CD4 count ≤ 200.Keywords: weight change, PLWH, ART, linear mixed effect model, EthiopiaWeldesenbet ABAyele TASisay MMTusa BSKebede SADove Medical Pressarticleweight changeplwhartlinear mixed effect modelethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 373-380 (2020)
institution DOAJ
collection DOAJ
language EN
topic weight change
plwh
art
linear mixed effect model
ethiopia
Immunologic diseases. Allergy
RC581-607
spellingShingle weight change
plwh
art
linear mixed effect model
ethiopia
Immunologic diseases. Allergy
RC581-607
Weldesenbet AB
Ayele TA
Sisay MM
Tusa BS
Kebede SA
Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study
description Adisu Birhanu Weldesenbet,1 Tadesse Awoke Ayele,2 Malede Mequanent Sisay,2 Biruk Shalmeno Tusa,1 Sewnet Adem Kebede2 1Department of Epidemiology and Biostatistics, College of Health and Medical Sciences, Haramaya University, Haramaya, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Adisu Birhanu Weldesenbet Tel +251968295598Email adisuebi2009@gmail.comBackground: Human immunodeficiency virus (HIV) remains a major global public health issue, particularly in Africa. In resource-limited settings like Ethiopia, regular weight measurement and monitoring is useful in the examination of patient response to antiretroviral therapy and in clinical decision-making. However, there is a paucity of evidence on factors that affect longitudinal weight change. Therefore, the present study was intended to identify predictors of weight change among people living with HIV (PLWH) in West Hararghe, Ethiopia.Methods: An institutional-based retrospective cohort study was conducted among 558 PLWH aged 18 years and above from September 2013 to January 2019 at Chiro Zonal Hospital and Gelemso General Hospital in West Hararghe zone, Ethiopia. Data were entered in Epi info 7 and analyzed in R software. The linear mixed effect regression model was used to identify predictors of longitudinal change in weight. Regression coefficients with their 95% confidence intervals were used to indicate the strength and significance of the association.Results: Weight showed improvement in follow-up periods. In this study, age of respondent (beta=0.136, 95% CI, 0.044:0.227), time since the initiation of antiretroviral therapy (ART) (beta=0.089, 95% CI, 0.075:0.104), primary educational status (beta=2.403, 95% CI, 0.540:4.266), secondary educational status (beta=4.035, 95% CI, 1.666:6.404), tertiary and above educational status (beta=3.444, 95% CI, 0.330:6.558), sex (beta= − 5.514, 95% CI, -7.260:-3.768), ambulatory functional status (beta= − 3.419, 95% CI, − 6.169:-0.668) and baseline CD4 count (≤ 200) (beta=2.205, 95% CI, 0.593, 3.817) were significant predictors of longitudinal weight change.Conclusion: We observed an increment in weight among PLWH who were on ART in Ethiopia. Educational status, time since the beginning of ART, age and having CD4 count above 200 have contributed positively to the change in weight, while ambulatory functional status and being female are negatively associated with longitudinal change in weight. Close monitoring is recommended for patients with ambulatory baseline functional status and for patients with baseline CD4 count ≤ 200.Keywords: weight change, PLWH, ART, linear mixed effect model, Ethiopia
format article
author Weldesenbet AB
Ayele TA
Sisay MM
Tusa BS
Kebede SA
author_facet Weldesenbet AB
Ayele TA
Sisay MM
Tusa BS
Kebede SA
author_sort Weldesenbet AB
title Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study
title_short Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study
title_full Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study
title_fullStr Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study
title_full_unstemmed Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study
title_sort predictors of change in weight among people living with hiv on antiretroviral treatment in west hararghe zone, ethiopia: a retrospective longitudinal study
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/9e6de74945dd4701bae1c27a9bd32fe9
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