Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study
Adisu Birhanu Weldesenbet,1 Tadesse Awoke Ayele,2 Malede Mequanent Sisay,2 Biruk Shalmeno Tusa,1 Sewnet Adem Kebede2 1Department of Epidemiology and Biostatistics, College of Health and Medical Sciences, Haramaya University, Haramaya, Ethiopia; 2Department of Epidemiology and Biostatistics, Institut...
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2020
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oai:doaj.org-article:9e6de74945dd4701bae1c27a9bd32fe92021-12-02T12:57:14ZPredictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study1179-1373https://doaj.org/article/9e6de74945dd4701bae1c27a9bd32fe92020-08-01T00:00:00Zhttps://www.dovepress.com/predictors-of-change-in-weight-among-people-living-with-hiv-on-antiret-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Adisu Birhanu Weldesenbet,1 Tadesse Awoke Ayele,2 Malede Mequanent Sisay,2 Biruk Shalmeno Tusa,1 Sewnet Adem Kebede2 1Department of Epidemiology and Biostatistics, College of Health and Medical Sciences, Haramaya University, Haramaya, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Adisu Birhanu Weldesenbet Tel +251968295598Email adisuebi2009@gmail.comBackground: Human immunodeficiency virus (HIV) remains a major global public health issue, particularly in Africa. In resource-limited settings like Ethiopia, regular weight measurement and monitoring is useful in the examination of patient response to antiretroviral therapy and in clinical decision-making. However, there is a paucity of evidence on factors that affect longitudinal weight change. Therefore, the present study was intended to identify predictors of weight change among people living with HIV (PLWH) in West Hararghe, Ethiopia.Methods: An institutional-based retrospective cohort study was conducted among 558 PLWH aged 18 years and above from September 2013 to January 2019 at Chiro Zonal Hospital and Gelemso General Hospital in West Hararghe zone, Ethiopia. Data were entered in Epi info 7 and analyzed in R software. The linear mixed effect regression model was used to identify predictors of longitudinal change in weight. Regression coefficients with their 95% confidence intervals were used to indicate the strength and significance of the association.Results: Weight showed improvement in follow-up periods. In this study, age of respondent (beta=0.136, 95% CI, 0.044:0.227), time since the initiation of antiretroviral therapy (ART) (beta=0.089, 95% CI, 0.075:0.104), primary educational status (beta=2.403, 95% CI, 0.540:4.266), secondary educational status (beta=4.035, 95% CI, 1.666:6.404), tertiary and above educational status (beta=3.444, 95% CI, 0.330:6.558), sex (beta= − 5.514, 95% CI, -7.260:-3.768), ambulatory functional status (beta= − 3.419, 95% CI, − 6.169:-0.668) and baseline CD4 count (≤ 200) (beta=2.205, 95% CI, 0.593, 3.817) were significant predictors of longitudinal weight change.Conclusion: We observed an increment in weight among PLWH who were on ART in Ethiopia. Educational status, time since the beginning of ART, age and having CD4 count above 200 have contributed positively to the change in weight, while ambulatory functional status and being female are negatively associated with longitudinal change in weight. Close monitoring is recommended for patients with ambulatory baseline functional status and for patients with baseline CD4 count ≤ 200.Keywords: weight change, PLWH, ART, linear mixed effect model, EthiopiaWeldesenbet ABAyele TASisay MMTusa BSKebede SADove Medical Pressarticleweight changeplwhartlinear mixed effect modelethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 373-380 (2020) |
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weight change plwh art linear mixed effect model ethiopia Immunologic diseases. Allergy RC581-607 |
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weight change plwh art linear mixed effect model ethiopia Immunologic diseases. Allergy RC581-607 Weldesenbet AB Ayele TA Sisay MM Tusa BS Kebede SA Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study |
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Adisu Birhanu Weldesenbet,1 Tadesse Awoke Ayele,2 Malede Mequanent Sisay,2 Biruk Shalmeno Tusa,1 Sewnet Adem Kebede2 1Department of Epidemiology and Biostatistics, College of Health and Medical Sciences, Haramaya University, Haramaya, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Adisu Birhanu Weldesenbet Tel +251968295598Email adisuebi2009@gmail.comBackground: Human immunodeficiency virus (HIV) remains a major global public health issue, particularly in Africa. In resource-limited settings like Ethiopia, regular weight measurement and monitoring is useful in the examination of patient response to antiretroviral therapy and in clinical decision-making. However, there is a paucity of evidence on factors that affect longitudinal weight change. Therefore, the present study was intended to identify predictors of weight change among people living with HIV (PLWH) in West Hararghe, Ethiopia.Methods: An institutional-based retrospective cohort study was conducted among 558 PLWH aged 18 years and above from September 2013 to January 2019 at Chiro Zonal Hospital and Gelemso General Hospital in West Hararghe zone, Ethiopia. Data were entered in Epi info 7 and analyzed in R software. The linear mixed effect regression model was used to identify predictors of longitudinal change in weight. Regression coefficients with their 95% confidence intervals were used to indicate the strength and significance of the association.Results: Weight showed improvement in follow-up periods. In this study, age of respondent (beta=0.136, 95% CI, 0.044:0.227), time since the initiation of antiretroviral therapy (ART) (beta=0.089, 95% CI, 0.075:0.104), primary educational status (beta=2.403, 95% CI, 0.540:4.266), secondary educational status (beta=4.035, 95% CI, 1.666:6.404), tertiary and above educational status (beta=3.444, 95% CI, 0.330:6.558), sex (beta= − 5.514, 95% CI, -7.260:-3.768), ambulatory functional status (beta= − 3.419, 95% CI, − 6.169:-0.668) and baseline CD4 count (≤ 200) (beta=2.205, 95% CI, 0.593, 3.817) were significant predictors of longitudinal weight change.Conclusion: We observed an increment in weight among PLWH who were on ART in Ethiopia. Educational status, time since the beginning of ART, age and having CD4 count above 200 have contributed positively to the change in weight, while ambulatory functional status and being female are negatively associated with longitudinal change in weight. Close monitoring is recommended for patients with ambulatory baseline functional status and for patients with baseline CD4 count ≤ 200.Keywords: weight change, PLWH, ART, linear mixed effect model, Ethiopia |
format |
article |
author |
Weldesenbet AB Ayele TA Sisay MM Tusa BS Kebede SA |
author_facet |
Weldesenbet AB Ayele TA Sisay MM Tusa BS Kebede SA |
author_sort |
Weldesenbet AB |
title |
Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study |
title_short |
Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study |
title_full |
Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study |
title_fullStr |
Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study |
title_full_unstemmed |
Predictors of Change in Weight Among People Living with HIV on Antiretroviral Treatment in West Hararghe Zone, Ethiopia: A Retrospective Longitudinal Study |
title_sort |
predictors of change in weight among people living with hiv on antiretroviral treatment in west hararghe zone, ethiopia: a retrospective longitudinal study |
publisher |
Dove Medical Press |
publishDate |
2020 |
url |
https://doaj.org/article/9e6de74945dd4701bae1c27a9bd32fe9 |
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