Recent Progress of Ferroptosis in Lung Diseases

Ferroptosis is a new form of programmed cell death due to iron-dependent excess accumulation of lipid peroxides and differs from other programmed cell deaths in morphological and biochemical characteristics. The process of ferroptosis is precisely regulated by iron metabolism, lipid metabolism, amin...

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Autores principales:	Shangjiang Yu, Jinqiu Jia, Jinyu Zheng, Yiyang Zhou, Danyun Jia, Junlu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ferroptosis mechanism lung diseases iron-dependent programmed cell death Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9e70578952a54fbb8031a9d2c7d83f55
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spelling	oai:doaj.org-article:9e70578952a54fbb8031a9d2c7d83f552021-11-16T05:14:11ZRecent Progress of Ferroptosis in Lung Diseases2296-634X10.3389/fcell.2021.789517https://doaj.org/article/9e70578952a54fbb8031a9d2c7d83f552021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.789517/fullhttps://doaj.org/toc/2296-634XFerroptosis is a new form of programmed cell death due to iron-dependent excess accumulation of lipid peroxides and differs from other programmed cell deaths in morphological and biochemical characteristics. The process of ferroptosis is precisely regulated by iron metabolism, lipid metabolism, amino acid metabolism, and numerous signaling pathways, and plays a complex role in many pathophysiological processes. Recent studies have found that ferroptosis is closely associated with the development and progression of many lung diseases, including acute lung injury, pulmonary ischemia-reperfusion injury, lung cancer, chronic obstructive pulmonary disease, and pulmonary fibrosis. Here, we present a review of the main regulatory mechanisms of ferroptosis and its research progress in the pathogenesis and treatment of lung diseases, with the aim of providing new ideas for basic and clinical research of lung-related diseases.Shangjiang YuJinqiu JiaJinyu ZhengYiyang ZhouDanyun JiaJunlu WangFrontiers Media S.A.articleferroptosismechanismlung diseasesiron-dependentprogrammed cell deathBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferroptosis mechanism lung diseases iron-dependent programmed cell death Biology (General) QH301-705.5
spellingShingle	ferroptosis mechanism lung diseases iron-dependent programmed cell death Biology (General) QH301-705.5 Shangjiang Yu Jinqiu Jia Jinyu Zheng Yiyang Zhou Danyun Jia Junlu Wang Recent Progress of Ferroptosis in Lung Diseases
description	Ferroptosis is a new form of programmed cell death due to iron-dependent excess accumulation of lipid peroxides and differs from other programmed cell deaths in morphological and biochemical characteristics. The process of ferroptosis is precisely regulated by iron metabolism, lipid metabolism, amino acid metabolism, and numerous signaling pathways, and plays a complex role in many pathophysiological processes. Recent studies have found that ferroptosis is closely associated with the development and progression of many lung diseases, including acute lung injury, pulmonary ischemia-reperfusion injury, lung cancer, chronic obstructive pulmonary disease, and pulmonary fibrosis. Here, we present a review of the main regulatory mechanisms of ferroptosis and its research progress in the pathogenesis and treatment of lung diseases, with the aim of providing new ideas for basic and clinical research of lung-related diseases.
format	article
author	Shangjiang Yu Jinqiu Jia Jinyu Zheng Yiyang Zhou Danyun Jia Junlu Wang
author_facet	Shangjiang Yu Jinqiu Jia Jinyu Zheng Yiyang Zhou Danyun Jia Junlu Wang
author_sort	Shangjiang Yu
title	Recent Progress of Ferroptosis in Lung Diseases
title_short	Recent Progress of Ferroptosis in Lung Diseases
title_full	Recent Progress of Ferroptosis in Lung Diseases
title_fullStr	Recent Progress of Ferroptosis in Lung Diseases
title_full_unstemmed	Recent Progress of Ferroptosis in Lung Diseases
title_sort	recent progress of ferroptosis in lung diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9e70578952a54fbb8031a9d2c7d83f55
work_keys_str_mv	AT shangjiangyu recentprogressofferroptosisinlungdiseases AT jinqiujia recentprogressofferroptosisinlungdiseases AT jinyuzheng recentprogressofferroptosisinlungdiseases AT yiyangzhou recentprogressofferroptosisinlungdiseases AT danyunjia recentprogressofferroptosisinlungdiseases AT junluwang recentprogressofferroptosisinlungdiseases
_version_	1718426684987801600

Recent Progress of Ferroptosis in Lung Diseases

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