Conformational heterogeneity of the calmodulin binding interface

Calmodulin is an important calcium sensor that can recognise and interact with a large range of proteins. Here, the authors use molecular dynamics simulations and Markov state models to show that the range of binding conformations adopted without substrate can help explain its diverse and specific b...

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Autores principales:	Diwakar Shukla, Ariana Peck, Vijay S. Pande
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e79a6d3f3e04b1184f9366e42aca192
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spelling	oai:doaj.org-article:9e79a6d3f3e04b1184f9366e42aca1922021-12-02T17:33:20ZConformational heterogeneity of the calmodulin binding interface10.1038/ncomms109102041-1723https://doaj.org/article/9e79a6d3f3e04b1184f9366e42aca1922016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms10910https://doaj.org/toc/2041-1723Calmodulin is an important calcium sensor that can recognise and interact with a large range of proteins. Here, the authors use molecular dynamics simulations and Markov state models to show that the range of binding conformations adopted without substrate can help explain its diverse and specific binding.Diwakar ShuklaAriana PeckVijay S. PandeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diwakar Shukla Ariana Peck Vijay S. Pande Conformational heterogeneity of the calmodulin binding interface
description	Calmodulin is an important calcium sensor that can recognise and interact with a large range of proteins. Here, the authors use molecular dynamics simulations and Markov state models to show that the range of binding conformations adopted without substrate can help explain its diverse and specific binding.
format	article
author	Diwakar Shukla Ariana Peck Vijay S. Pande
author_facet	Diwakar Shukla Ariana Peck Vijay S. Pande
author_sort	Diwakar Shukla
title	Conformational heterogeneity of the calmodulin binding interface
title_short	Conformational heterogeneity of the calmodulin binding interface
title_full	Conformational heterogeneity of the calmodulin binding interface
title_fullStr	Conformational heterogeneity of the calmodulin binding interface
title_full_unstemmed	Conformational heterogeneity of the calmodulin binding interface
title_sort	conformational heterogeneity of the calmodulin binding interface
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9e79a6d3f3e04b1184f9366e42aca192
work_keys_str_mv	AT diwakarshukla conformationalheterogeneityofthecalmodulinbindinginterface AT arianapeck conformationalheterogeneityofthecalmodulinbindinginterface AT vijayspande conformationalheterogeneityofthecalmodulinbindinginterface
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Conformational heterogeneity of the calmodulin binding interface

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