Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator and haploinsufficiency of its KANSL1 subunit results in the Koolen-de Vries syndrome in humans. Here, the authors identify the BET protein BRD4 as evolutionary conserved co-factor of the NSL com...

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Autores principales:	Aline Gaub, Bilal N. Sheikh, M. Felicia Basilicata, Marie Vincent, Mathilde Nizon, Cindy Colson, Matthew J. Bird, James E. Bradner, Julien Thevenon, Michael Boutros, Asifa Akhtar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e7c4151d8d24cc0b2f5e39ab82d1466
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spelling	oai:doaj.org-article:9e7c4151d8d24cc0b2f5e39ab82d14662021-12-02T14:41:26ZEvolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation10.1038/s41467-020-16103-02041-1723https://doaj.org/article/9e7c4151d8d24cc0b2f5e39ab82d14662020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16103-0https://doaj.org/toc/2041-1723The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator and haploinsufficiency of its KANSL1 subunit results in the Koolen-de Vries syndrome in humans. Here, the authors identify the BET protein BRD4 as evolutionary conserved co-factor of the NSL complex and provide evidence that NSL-deposited histone acetylation induces BRD4 recruitment for transcription of constitutively active genes.Aline GaubBilal N. SheikhM. Felicia BasilicataMarie VincentMathilde NizonCindy ColsonMatthew J. BirdJames E. BradnerJulien ThevenonMichael BoutrosAsifa AkhtarNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aline Gaub Bilal N. Sheikh M. Felicia Basilicata Marie Vincent Mathilde Nizon Cindy Colson Matthew J. Bird James E. Bradner Julien Thevenon Michael Boutros Asifa Akhtar Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
description	The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator and haploinsufficiency of its KANSL1 subunit results in the Koolen-de Vries syndrome in humans. Here, the authors identify the BET protein BRD4 as evolutionary conserved co-factor of the NSL complex and provide evidence that NSL-deposited histone acetylation induces BRD4 recruitment for transcription of constitutively active genes.
format	article
author	Aline Gaub Bilal N. Sheikh M. Felicia Basilicata Marie Vincent Mathilde Nizon Cindy Colson Matthew J. Bird James E. Bradner Julien Thevenon Michael Boutros Asifa Akhtar
author_facet	Aline Gaub Bilal N. Sheikh M. Felicia Basilicata Marie Vincent Mathilde Nizon Cindy Colson Matthew J. Bird James E. Bradner Julien Thevenon Michael Boutros Asifa Akhtar
author_sort	Aline Gaub
title	Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
title_short	Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
title_full	Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
title_fullStr	Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
title_full_unstemmed	Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
title_sort	evolutionary conserved nsl complex/brd4 axis controls transcription activation via histone acetylation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9e7c4151d8d24cc0b2f5e39ab82d1466
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Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

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