Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator and haploinsufficiency of its KANSL1 subunit results in the Koolen-de Vries syndrome in humans. Here, the authors identify the BET protein BRD4 as evolutionary conserved co-factor of the NSL com...
Guardado en:
Autores principales: | Aline Gaub, Bilal N. Sheikh, M. Felicia Basilicata, Marie Vincent, Mathilde Nizon, Cindy Colson, Matthew J. Bird, James E. Bradner, Julien Thevenon, Michael Boutros, Asifa Akhtar |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/9e7c4151d8d24cc0b2f5e39ab82d1466 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Transcription shapes genome-wide histone acetylation patterns
por: Benjamin J. E. Martin, et al.
Publicado: (2021) -
Investigation of the acetylation mechanism by GCN5 histone acetyltransferase.
por: Junfeng Jiang, et al.
Publicado: (2012) -
Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells
por: Claudia Isabelle Keller Valsecchi, et al.
Publicado: (2018) -
Histone chaperone exploits intrinsic disorder to switch acetylation specificity
por: Nataliya Danilenko, et al.
Publicado: (2019) -
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
por: Sant-Rayn Pasricha, et al.
Publicado: (2017)