Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator and haploinsufficiency of its KANSL1 subunit results in the Koolen-de Vries syndrome in humans. Here, the authors identify the BET protein BRD4 as evolutionary conserved co-factor of the NSL com...

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Autores principales: Aline Gaub, Bilal N. Sheikh, M. Felicia Basilicata, Marie Vincent, Mathilde Nizon, Cindy Colson, Matthew J. Bird, James E. Bradner, Julien Thevenon, Michael Boutros, Asifa Akhtar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/9e7c4151d8d24cc0b2f5e39ab82d1466
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