Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.

DSCR1/ RCAN1 is a chromosome 21 gene found to be overexpressed in the brains of Down syndrome (DS) and postulated as a good candidate to contribute to mental disability. However, even though Rcan1 knockout mice have pronounced spatial learning and memory deficits, the possible deleterious effects of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mara Dierssen, Gloria Arqué, Jerome McDonald, Nuria Andreu, Carmen Martínez-Cué, Jesús Flórez, Cristina Fillat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e7ed7bf502a4cbc88351f0f74b27a57
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e7ed7bf502a4cbc88351f0f74b27a57
record_format	dspace
spelling	oai:doaj.org-article:9e7ed7bf502a4cbc88351f0f74b27a572021-11-18T06:58:10ZBehavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.1932-620310.1371/journal.pone.0017010https://doaj.org/article/9e7ed7bf502a4cbc88351f0f74b27a572011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21364922/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203DSCR1/ RCAN1 is a chromosome 21 gene found to be overexpressed in the brains of Down syndrome (DS) and postulated as a good candidate to contribute to mental disability. However, even though Rcan1 knockout mice have pronounced spatial learning and memory deficits, the possible deleterious effects of its overexpression in DS are not well understood. We have generated a transgenic mouse model overexpressing DSCR1/RCAN1 in the brain and analyzed the effect of RCAN1 overexpression on cognitive function. TgRCAN1 mice present a marked disruption of the learning process in a visuo-spatial learning task. However, no significant differences were observed in the performance of the memory phase of the test (removal session) nor in a step-down passive avoidance task, thus suggesting that once learning has been established, the animals are able to consolidate the information in the longer term.Mara DierssenGloria ArquéJerome McDonaldNuria AndreuCarmen Martínez-CuéJesús FlórezCristina FillatPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17010 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mara Dierssen Gloria Arqué Jerome McDonald Nuria Andreu Carmen Martínez-Cué Jesús Flórez Cristina Fillat Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
description	DSCR1/ RCAN1 is a chromosome 21 gene found to be overexpressed in the brains of Down syndrome (DS) and postulated as a good candidate to contribute to mental disability. However, even though Rcan1 knockout mice have pronounced spatial learning and memory deficits, the possible deleterious effects of its overexpression in DS are not well understood. We have generated a transgenic mouse model overexpressing DSCR1/RCAN1 in the brain and analyzed the effect of RCAN1 overexpression on cognitive function. TgRCAN1 mice present a marked disruption of the learning process in a visuo-spatial learning task. However, no significant differences were observed in the performance of the memory phase of the test (removal session) nor in a step-down passive avoidance task, thus suggesting that once learning has been established, the animals are able to consolidate the information in the longer term.
format	article
author	Mara Dierssen Gloria Arqué Jerome McDonald Nuria Andreu Carmen Martínez-Cué Jesús Flórez Cristina Fillat
author_facet	Mara Dierssen Gloria Arqué Jerome McDonald Nuria Andreu Carmen Martínez-Cué Jesús Flórez Cristina Fillat
author_sort	Mara Dierssen
title	Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
title_short	Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
title_full	Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
title_fullStr	Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
title_full_unstemmed	Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
title_sort	behavioral characterization of a mouse model overexpressing dscr1/ rcan1.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/9e7ed7bf502a4cbc88351f0f74b27a57
work_keys_str_mv	AT maradierssen behavioralcharacterizationofamousemodeloverexpressingdscr1rcan1 AT gloriaarque behavioralcharacterizationofamousemodeloverexpressingdscr1rcan1 AT jeromemcdonald behavioralcharacterizationofamousemodeloverexpressingdscr1rcan1 AT nuriaandreu behavioralcharacterizationofamousemodeloverexpressingdscr1rcan1 AT carmenmartinezcue behavioralcharacterizationofamousemodeloverexpressingdscr1rcan1 AT jesusflorez behavioralcharacterizationofamousemodeloverexpressingdscr1rcan1 AT cristinafillat behavioralcharacterizationofamousemodeloverexpressingdscr1rcan1
_version_	1718424121897910272

Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.

Ejemplares similares