Increased cardiac myocyte PDE5 levels in human and murine pressure overload hypertrophy contribute to adverse LV remodeling.

Increased cardiac myocyte PDE5 levels in human and murine pressure overload hypertrophy contribute to adverse LV remodeling.

<h4>Background</h4>The intracellular second messenger cGMP protects the heart under pathological conditions. We examined expression of phosphodiesterase 5 (PDE5), an enzyme that hydrolyzes cGMP, in human and mouse hearts subjected to sustained left ventricular (LV) pressure overload. We...

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Autores principales: Sara Vandenwijngaert, Peter Pokreisz, Hadewich Hermans, Hilde Gillijns, Marijke Pellens, Noortje A M Bax, Giulia Coppiello, Wouter Oosterlinck, Agnes Balogh, Zoltan Papp, Carlijn V C Bouten, Jozef Bartunek, Jan D'hooge, Aernout Luttun, Erik Verbeken, Marie Christine Herregods, Paul Herijgers, Kenneth D Bloch, Stefan Janssens
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9e817f3d05204959aef0b9fb7fe1b3fc
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