DNA Methylation and Immune Memory Response

The generation of memory is a cardinal feature of the adaptive immune response, involving different factors in a complex process of cellular differentiation. This process is essential for protecting the second encounter with pathogens and is the mechanism by which vaccines work. Epigenetic changes p...

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Autores principales:	Nathalia Noschang Mittelstaedt, André Luiz Becker, Deise Nascimento de Freitas, Rafael F. Zanin, Renato T. Stein, Ana Paula Duarte de Souza
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	B cells T cells epigenetic DNA methylation memory response Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9e834b62e9e442798bc3e2c4020671df
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spelling	oai:doaj.org-article:9e834b62e9e442798bc3e2c4020671df2021-11-25T17:09:31ZDNA Methylation and Immune Memory Response10.3390/cells101129432073-4409https://doaj.org/article/9e834b62e9e442798bc3e2c4020671df2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2943https://doaj.org/toc/2073-4409The generation of memory is a cardinal feature of the adaptive immune response, involving different factors in a complex process of cellular differentiation. This process is essential for protecting the second encounter with pathogens and is the mechanism by which vaccines work. Epigenetic changes play important roles in the regulation of cell differentiation events. There are three types of epigenetic regulation: DNA methylation, histone modification, and microRNA expression. One of these epigenetic changes, DNA methylation, occurs in cytosine residues, mainly in CpG dinucleotides. This brief review aimed to analyse the literature to verify the involvement of DNA methylation during memory T and B cell development. Several studies have highlighted the importance of the DNA methyltransferases, enzymes that catalyse the methylation of DNA, during memory differentiation, maintenance, and function. The methylation profile within different subsets of naïve activated and memory cells could be an interesting tool to help monitor immune memory response.Nathalia Noschang MittelstaedtAndré Luiz BeckerDeise Nascimento de FreitasRafael F. ZaninRenato T. SteinAna Paula Duarte de SouzaMDPI AGarticleB cellsT cellsepigeneticDNA methylationmemory responseBiology (General)QH301-705.5ENCells, Vol 10, Iss 2943, p 2943 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	B cells T cells epigenetic DNA methylation memory response Biology (General) QH301-705.5
spellingShingle	B cells T cells epigenetic DNA methylation memory response Biology (General) QH301-705.5 Nathalia Noschang Mittelstaedt André Luiz Becker Deise Nascimento de Freitas Rafael F. Zanin Renato T. Stein Ana Paula Duarte de Souza DNA Methylation and Immune Memory Response
description	The generation of memory is a cardinal feature of the adaptive immune response, involving different factors in a complex process of cellular differentiation. This process is essential for protecting the second encounter with pathogens and is the mechanism by which vaccines work. Epigenetic changes play important roles in the regulation of cell differentiation events. There are three types of epigenetic regulation: DNA methylation, histone modification, and microRNA expression. One of these epigenetic changes, DNA methylation, occurs in cytosine residues, mainly in CpG dinucleotides. This brief review aimed to analyse the literature to verify the involvement of DNA methylation during memory T and B cell development. Several studies have highlighted the importance of the DNA methyltransferases, enzymes that catalyse the methylation of DNA, during memory differentiation, maintenance, and function. The methylation profile within different subsets of naïve activated and memory cells could be an interesting tool to help monitor immune memory response.
format	article
author	Nathalia Noschang Mittelstaedt André Luiz Becker Deise Nascimento de Freitas Rafael F. Zanin Renato T. Stein Ana Paula Duarte de Souza
author_facet	Nathalia Noschang Mittelstaedt André Luiz Becker Deise Nascimento de Freitas Rafael F. Zanin Renato T. Stein Ana Paula Duarte de Souza
author_sort	Nathalia Noschang Mittelstaedt
title	DNA Methylation and Immune Memory Response
title_short	DNA Methylation and Immune Memory Response
title_full	DNA Methylation and Immune Memory Response
title_fullStr	DNA Methylation and Immune Memory Response
title_full_unstemmed	DNA Methylation and Immune Memory Response
title_sort	dna methylation and immune memory response
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9e834b62e9e442798bc3e2c4020671df
work_keys_str_mv	AT nathalianoschangmittelstaedt dnamethylationandimmunememoryresponse AT andreluizbecker dnamethylationandimmunememoryresponse AT deisenascimentodefreitas dnamethylationandimmunememoryresponse AT rafaelfzanin dnamethylationandimmunememoryresponse AT renatotstein dnamethylationandimmunememoryresponse AT anapauladuartedesouza dnamethylationandimmunememoryresponse
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DNA Methylation and Immune Memory Response

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