Complex disease interventions from a network model for type 2 diabetes.

There is accumulating evidence that the proteins encoded by the genes associated with a common disorder interact with each other, participate in similar pathways and share GO terms. It has been anticipated that the functional modules in a disease related functional linkage network are informative to...

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Autores principales:	Deniz Rende, Nihat Baysal, Betul Kirdar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e85728006e14867bb93b1681d856c66
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spelling	oai:doaj.org-article:9e85728006e14867bb93b1681d856c662021-11-18T07:42:18ZComplex disease interventions from a network model for type 2 diabetes.1932-620310.1371/journal.pone.0065854https://doaj.org/article/9e85728006e14867bb93b1681d856c662013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23776558/?tool=EBIhttps://doaj.org/toc/1932-6203There is accumulating evidence that the proteins encoded by the genes associated with a common disorder interact with each other, participate in similar pathways and share GO terms. It has been anticipated that the functional modules in a disease related functional linkage network are informative to reveal significant metabolic processes and disease's associations with other complex disorders. In the current study, Type 2 diabetes associated functional linkage network (T2DFN) containing 2770 proteins and 15041 linkages was constructed. The functional modules in this network were scored and evaluated in terms of shared pathways, co-localization, co-expression and associations with similar diseases. The assembly of top scoring overlapping members in the functional modules revealed that, along with the well known biological pathways, circadian rhythm, diverse actions of nuclear receptors in steroid and retinoic acid metabolisms have significant occurrence in the pathophysiology of the disease. The disease's association with other metabolic and neuromuscular disorders was established through shared proteins. Nuclear receptor NRIP1 has a pivotal role in lipid and carbohydrate metabolism, indicating the need to investigate subsequent effects of NRIP1 on Type 2 diabetes. Our study also revealed that CREB binding protein (CREBBP) and cardiotrophin-1 (CTF1) have suggestive roles in linking Type 2 diabetes and neuromuscular diseases.Deniz RendeNihat BaysalBetul KirdarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65854 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Deniz Rende Nihat Baysal Betul Kirdar Complex disease interventions from a network model for type 2 diabetes.
description	There is accumulating evidence that the proteins encoded by the genes associated with a common disorder interact with each other, participate in similar pathways and share GO terms. It has been anticipated that the functional modules in a disease related functional linkage network are informative to reveal significant metabolic processes and disease's associations with other complex disorders. In the current study, Type 2 diabetes associated functional linkage network (T2DFN) containing 2770 proteins and 15041 linkages was constructed. The functional modules in this network were scored and evaluated in terms of shared pathways, co-localization, co-expression and associations with similar diseases. The assembly of top scoring overlapping members in the functional modules revealed that, along with the well known biological pathways, circadian rhythm, diverse actions of nuclear receptors in steroid and retinoic acid metabolisms have significant occurrence in the pathophysiology of the disease. The disease's association with other metabolic and neuromuscular disorders was established through shared proteins. Nuclear receptor NRIP1 has a pivotal role in lipid and carbohydrate metabolism, indicating the need to investigate subsequent effects of NRIP1 on Type 2 diabetes. Our study also revealed that CREB binding protein (CREBBP) and cardiotrophin-1 (CTF1) have suggestive roles in linking Type 2 diabetes and neuromuscular diseases.
format	article
author	Deniz Rende Nihat Baysal Betul Kirdar
author_facet	Deniz Rende Nihat Baysal Betul Kirdar
author_sort	Deniz Rende
title	Complex disease interventions from a network model for type 2 diabetes.
title_short	Complex disease interventions from a network model for type 2 diabetes.
title_full	Complex disease interventions from a network model for type 2 diabetes.
title_fullStr	Complex disease interventions from a network model for type 2 diabetes.
title_full_unstemmed	Complex disease interventions from a network model for type 2 diabetes.
title_sort	complex disease interventions from a network model for type 2 diabetes.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9e85728006e14867bb93b1681d856c66
work_keys_str_mv	AT denizrende complexdiseaseinterventionsfromanetworkmodelfortype2diabetes AT nihatbaysal complexdiseaseinterventionsfromanetworkmodelfortype2diabetes AT betulkirdar complexdiseaseinterventionsfromanetworkmodelfortype2diabetes
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Complex disease interventions from a network model for type 2 diabetes.

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