Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study

Abstract We investigated the potential of mid-regional pro-adrenomedullin (MR-proADM) for use as a novel biomarker for arterial stiffness as the criterion for vascular failure and cardiometabolic disease (obesity, hypertension, dyslipidemia, diabetes, and metabolic syndrome) compared with high-sensi...

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Autores principales:	Teruhide Koyama, Nagato Kuriyama, Yosuke Suzuki, Satoshi Saito, Ryota Tanaka, Motoshi Iwao, Megumu Tanaka, Takakuni Maki, Hiroki Itoh, Masafumi Ihara, Takayuki Shindo, Ritei Uehara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e8c111562614512ae3245ecf977792c
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spelling	oai:doaj.org-article:9e8c111562614512ae3245ecf977792c2021-12-02T14:12:08ZMid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study10.1038/s41598-020-79525-22045-2322https://doaj.org/article/9e8c111562614512ae3245ecf977792c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79525-2https://doaj.org/toc/2045-2322Abstract We investigated the potential of mid-regional pro-adrenomedullin (MR-proADM) for use as a novel biomarker for arterial stiffness as the criterion for vascular failure and cardiometabolic disease (obesity, hypertension, dyslipidemia, diabetes, and metabolic syndrome) compared with high-sensitivity C-reactive protein (hsCRP). Overall, 2169 individuals (702 men and 1467 women) were enrolled. Multiple regression analysis was performed to assess the association of MR-proADM and hsCRP with brachial-ankle pulse wave velocity (baPWV), adjusting for other variables. The diagnostic performance (accuracy) of MR-proADM with regard to the index of vascular failure was tested with the help of receiver operating characteristic curve analysis in the models. MR-proADM was significantly higher in participants with vascular failure, as defined by baPWV and/or its risk factors (obesity, hypertension, dyslipidemia, diabetes, and metabolic syndrome), than in control groups. Independent of cardiovascular risk factors (age, drinking, smoking, body mass index, systolic blood pressure, lipid and glycol metabolism), MR-proADM was significantly associated with baPWV, and MR-proADM showed higher areas under the curve of baPWV than hsCRP showed. MR-proADM is more suitable for the diagnosis of higher arterial stiffness as the criterion for vascular failure than hsCRP. Because vascular assessment is important to mitigate the most significant modifiable cardiovascular risk factors, MR-proADM may be useful as a novel biomarker on routine blood examination.Teruhide KoyamaNagato KuriyamaYosuke SuzukiSatoshi SaitoRyota TanakaMotoshi IwaoMegumu TanakaTakakuni MakiHiroki ItohMasafumi IharaTakayuki ShindoRitei UeharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Teruhide Koyama Nagato Kuriyama Yosuke Suzuki Satoshi Saito Ryota Tanaka Motoshi Iwao Megumu Tanaka Takakuni Maki Hiroki Itoh Masafumi Ihara Takayuki Shindo Ritei Uehara Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study
description	Abstract We investigated the potential of mid-regional pro-adrenomedullin (MR-proADM) for use as a novel biomarker for arterial stiffness as the criterion for vascular failure and cardiometabolic disease (obesity, hypertension, dyslipidemia, diabetes, and metabolic syndrome) compared with high-sensitivity C-reactive protein (hsCRP). Overall, 2169 individuals (702 men and 1467 women) were enrolled. Multiple regression analysis was performed to assess the association of MR-proADM and hsCRP with brachial-ankle pulse wave velocity (baPWV), adjusting for other variables. The diagnostic performance (accuracy) of MR-proADM with regard to the index of vascular failure was tested with the help of receiver operating characteristic curve analysis in the models. MR-proADM was significantly higher in participants with vascular failure, as defined by baPWV and/or its risk factors (obesity, hypertension, dyslipidemia, diabetes, and metabolic syndrome), than in control groups. Independent of cardiovascular risk factors (age, drinking, smoking, body mass index, systolic blood pressure, lipid and glycol metabolism), MR-proADM was significantly associated with baPWV, and MR-proADM showed higher areas under the curve of baPWV than hsCRP showed. MR-proADM is more suitable for the diagnosis of higher arterial stiffness as the criterion for vascular failure than hsCRP. Because vascular assessment is important to mitigate the most significant modifiable cardiovascular risk factors, MR-proADM may be useful as a novel biomarker on routine blood examination.
format	article
author	Teruhide Koyama Nagato Kuriyama Yosuke Suzuki Satoshi Saito Ryota Tanaka Motoshi Iwao Megumu Tanaka Takakuni Maki Hiroki Itoh Masafumi Ihara Takayuki Shindo Ritei Uehara
author_facet	Teruhide Koyama Nagato Kuriyama Yosuke Suzuki Satoshi Saito Ryota Tanaka Motoshi Iwao Megumu Tanaka Takakuni Maki Hiroki Itoh Masafumi Ihara Takayuki Shindo Ritei Uehara
author_sort	Teruhide Koyama
title	Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study
title_short	Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study
title_full	Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study
title_fullStr	Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study
title_full_unstemmed	Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study
title_sort	mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e8c111562614512ae3245ecf977792c
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Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study

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