Prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair

Abstract Hepatorenal dysfunction is a strong risk factor in patients with heart failure (HF). We investigated the prognostic significance of hepatorenal dysfunction in 172 consecutive patients undergoing transcatheter tricuspid valve repair (TTVR). The model for end-stage liver disease excluding int...

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Autores principales:	Tetsu Tanaka, Refik Kavsur, Atsushi Sugiura, Johanna Vogelhuber, Can Öztürk, Marcel Weber, Vedat Tiyerili, Sebastian Zimmer, Georg Nickenig, Marc Ulrich Becher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e8e6c05aadc46b7a938c6d9c4f8fd52
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spelling	oai:doaj.org-article:9e8e6c05aadc46b7a938c6d9c4f8fd522021-12-02T18:30:51ZPrognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair10.1038/s41598-021-93952-92045-2322https://doaj.org/article/9e8e6c05aadc46b7a938c6d9c4f8fd522021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93952-9https://doaj.org/toc/2045-2322Abstract Hepatorenal dysfunction is a strong risk factor in patients with heart failure (HF). We investigated the prognostic significance of hepatorenal dysfunction in 172 consecutive patients undergoing transcatheter tricuspid valve repair (TTVR). The model for end-stage liver disease excluding international normalized ratio (MELD-XI) score was calculated as 5.11 × ln(serum total bilirubin [mg/dl]) + 11.76 × ln(serum creatinine [mg/dl]) + 9.44. Patients were stratified into two groups: high (≥ 14) or low (< 14) MELD-XI score, according to the best cut-off value to predict a one-year composite outcome consisting of all-cause mortality and HF hospitalization. Compared to patients with low MELD-XI score (n = 121), patients with high MELD-XI score (n = 51) had a higher incidence of the composite outcome (47.1% vs. 17.4%; p < 0.0001). In the multivariable analysis, the MELD-XI score was an independent predictor of the composite outcome (adjusted hazard ratio: 1.12; 95% confidence interval [CI] 1.05–1.19; p = 0.0003). In addition, post-procedural TR < 3 + after TTVR was independently associated with a reduction in MELD-XI score six months after TTVR (adjusted odds ratio: 3.37; 95% CI 1.09–10.40; p = 0.03). Thus, the MELD-XI score was associated with the risk of one-year composite outcome, consisting of mortality and HF hospitalization, after TTVR and may help the risk stratification in patients undergoing TTVR.Tetsu TanakaRefik KavsurAtsushi SugiuraJohanna VogelhuberCan ÖztürkMarcel WeberVedat TiyeriliSebastian ZimmerGeorg NickenigMarc Ulrich BecherNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tetsu Tanaka Refik Kavsur Atsushi Sugiura Johanna Vogelhuber Can Öztürk Marcel Weber Vedat Tiyerili Sebastian Zimmer Georg Nickenig Marc Ulrich Becher Prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair
description	Abstract Hepatorenal dysfunction is a strong risk factor in patients with heart failure (HF). We investigated the prognostic significance of hepatorenal dysfunction in 172 consecutive patients undergoing transcatheter tricuspid valve repair (TTVR). The model for end-stage liver disease excluding international normalized ratio (MELD-XI) score was calculated as 5.11 × ln(serum total bilirubin [mg/dl]) + 11.76 × ln(serum creatinine [mg/dl]) + 9.44. Patients were stratified into two groups: high (≥ 14) or low (< 14) MELD-XI score, according to the best cut-off value to predict a one-year composite outcome consisting of all-cause mortality and HF hospitalization. Compared to patients with low MELD-XI score (n = 121), patients with high MELD-XI score (n = 51) had a higher incidence of the composite outcome (47.1% vs. 17.4%; p < 0.0001). In the multivariable analysis, the MELD-XI score was an independent predictor of the composite outcome (adjusted hazard ratio: 1.12; 95% confidence interval [CI] 1.05–1.19; p = 0.0003). In addition, post-procedural TR < 3 + after TTVR was independently associated with a reduction in MELD-XI score six months after TTVR (adjusted odds ratio: 3.37; 95% CI 1.09–10.40; p = 0.03). Thus, the MELD-XI score was associated with the risk of one-year composite outcome, consisting of mortality and HF hospitalization, after TTVR and may help the risk stratification in patients undergoing TTVR.
format	article
author	Tetsu Tanaka Refik Kavsur Atsushi Sugiura Johanna Vogelhuber Can Öztürk Marcel Weber Vedat Tiyerili Sebastian Zimmer Georg Nickenig Marc Ulrich Becher
author_facet	Tetsu Tanaka Refik Kavsur Atsushi Sugiura Johanna Vogelhuber Can Öztürk Marcel Weber Vedat Tiyerili Sebastian Zimmer Georg Nickenig Marc Ulrich Becher
author_sort	Tetsu Tanaka
title	Prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair
title_short	Prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair
title_full	Prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair
title_fullStr	Prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair
title_full_unstemmed	Prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair
title_sort	prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e8e6c05aadc46b7a938c6d9c4f8fd52
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Prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair

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