Concepts and practices used to develop functional PLGA-based nanoparticulate systems

Hongkee Sah,1,2 Laura A Thoma,2 Hari R Desu,2 Edel Sah,3 George C Wood21College of Pharmacy, Ewha Womans University, Sedaemun-gu, Seoul, South Korea; 2College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA; 3College of Science, University of Notre Dame, Notre Dame,...

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Autores principales:	Sah H, Thoma LA, Desu HR, Sah E, Wood GC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9e911acd158e4dfd8c0df827cbd733e3
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spelling	oai:doaj.org-article:9e911acd158e4dfd8c0df827cbd733e32021-12-02T02:38:34ZConcepts and practices used to develop functional PLGA-based nanoparticulate systems1176-91141178-2013https://doaj.org/article/9e911acd158e4dfd8c0df827cbd733e32013-02-01T00:00:00Zhttp://www.dovepress.com/concepts-and-practices-used-to-develop-functional-plga-based-nanoparti-a12267https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hongkee Sah,1,2 Laura A Thoma,2 Hari R Desu,2 Edel Sah,3 George C Wood21College of Pharmacy, Ewha Womans University, Sedaemun-gu, Seoul, South Korea; 2College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA; 3College of Science, University of Notre Dame, Notre Dame, IN, USAAbstract: The functionality of bare polylactide-co-glycolide (PLGA) nanoparticles is limited to drug depot or drug solubilization in their hard cores. They have inherent weaknesses as a drug-delivery system. For instance, when administered intravenously, the nanoparticles undergo rapid clearance from systemic circulation before reaching the site of action. Furthermore, plain PLGA nanoparticles cannot distinguish between different cell types. Recent research shows that surface functionalization of nanoparticles and development of new nanoparticulate dosage forms help overcome these delivery challenges and improve in-vivo performance. Immense research efforts have propelled the development of diverse functional PLGA-based nanoparticulate delivery systems. Representative examples include PEGylated micelles/nanoparticles (PEG, polyethylene glycol), polyplexes, polymersomes, core-shell&ndash;type lipid-PLGA hybrids, cell-PLGA hybrids, receptor-specific ligand-PLGA conjugates, and theranostics. Each PLGA-based nanoparticulate dosage form has specific features that distinguish it from other nanoparticulate systems. This review focuses on fundamental concepts and practices that are used in the development of various functional nanoparticulate dosage forms. We describe how the attributes of these functional nanoparticulate forms might contribute to achievement of desired therapeutic effects that are not attainable using conventional therapies. Functional PLGA-based nanoparticulate systems are expected to deliver chemotherapeutic, diagnostic, and imaging agents in a highly selective and effective manner.Keywords: nanoparticulate dosage forms, nanoparticles, polylactide-co-glycolide, functionalitySah HThoma LADesu HRSah EWood GCDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 747-765 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Sah H Thoma LA Desu HR Sah E Wood GC Concepts and practices used to develop functional PLGA-based nanoparticulate systems
description	Hongkee Sah,1,2 Laura A Thoma,2 Hari R Desu,2 Edel Sah,3 George C Wood21College of Pharmacy, Ewha Womans University, Sedaemun-gu, Seoul, South Korea; 2College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA; 3College of Science, University of Notre Dame, Notre Dame, IN, USAAbstract: The functionality of bare polylactide-co-glycolide (PLGA) nanoparticles is limited to drug depot or drug solubilization in their hard cores. They have inherent weaknesses as a drug-delivery system. For instance, when administered intravenously, the nanoparticles undergo rapid clearance from systemic circulation before reaching the site of action. Furthermore, plain PLGA nanoparticles cannot distinguish between different cell types. Recent research shows that surface functionalization of nanoparticles and development of new nanoparticulate dosage forms help overcome these delivery challenges and improve in-vivo performance. Immense research efforts have propelled the development of diverse functional PLGA-based nanoparticulate delivery systems. Representative examples include PEGylated micelles/nanoparticles (PEG, polyethylene glycol), polyplexes, polymersomes, core-shell&ndash;type lipid-PLGA hybrids, cell-PLGA hybrids, receptor-specific ligand-PLGA conjugates, and theranostics. Each PLGA-based nanoparticulate dosage form has specific features that distinguish it from other nanoparticulate systems. This review focuses on fundamental concepts and practices that are used in the development of various functional nanoparticulate dosage forms. We describe how the attributes of these functional nanoparticulate forms might contribute to achievement of desired therapeutic effects that are not attainable using conventional therapies. Functional PLGA-based nanoparticulate systems are expected to deliver chemotherapeutic, diagnostic, and imaging agents in a highly selective and effective manner.Keywords: nanoparticulate dosage forms, nanoparticles, polylactide-co-glycolide, functionality
format	article
author	Sah H Thoma LA Desu HR Sah E Wood GC
author_facet	Sah H Thoma LA Desu HR Sah E Wood GC
author_sort	Sah H
title	Concepts and practices used to develop functional PLGA-based nanoparticulate systems
title_short	Concepts and practices used to develop functional PLGA-based nanoparticulate systems
title_full	Concepts and practices used to develop functional PLGA-based nanoparticulate systems
title_fullStr	Concepts and practices used to develop functional PLGA-based nanoparticulate systems
title_full_unstemmed	Concepts and practices used to develop functional PLGA-based nanoparticulate systems
title_sort	concepts and practices used to develop functional plga-based nanoparticulate systems
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/9e911acd158e4dfd8c0df827cbd733e3
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Concepts and practices used to develop functional PLGA-based nanoparticulate systems

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