Dynamic 31P-MRI and 31P-MRS of lower leg muscles in heart failure patients

Abstract Impaired oxidative metabolism is one of multi-variate factors leading to exercise intolerance in heart failure patients. The purpose of the study was to demonstrate the use of dynamic 31P magnetic resonance spectroscopy (MRS) and 31P magnetic resonance imaging (MRI) techniques to measure PC...

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Autores principales:	Rajiv G. Menon, Ding Xia, Stuart D. Katz, Ravinder R. Regatte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e98d7af02b548e1a83de243c28ee62b
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spelling	oai:doaj.org-article:9e98d7af02b548e1a83de243c28ee62b2021-12-02T18:18:06ZDynamic 31P-MRI and 31P-MRS of lower leg muscles in heart failure patients10.1038/s41598-021-86392-y2045-2322https://doaj.org/article/9e98d7af02b548e1a83de243c28ee62b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86392-yhttps://doaj.org/toc/2045-2322Abstract Impaired oxidative metabolism is one of multi-variate factors leading to exercise intolerance in heart failure patients. The purpose of the study was to demonstrate the use of dynamic 31P magnetic resonance spectroscopy (MRS) and 31P magnetic resonance imaging (MRI) techniques to measure PCr resynthesis rate post-exercise as a biomarker for oxidative metabolism in skeletal muscle in HF patients and controls. In this prospective imaging study, we recruited six HF patients and five healthy controls. The imaging protocol included 31P-MRS, spectrally selective 3D turbo spin echo for 31P-MRI, and Dixon multi-echo GRE for fat–water imaging on a 3 T clinical MRI scanner. All the subjects were scanned pre-exercise, during plantar flexion exercise, and post-exercise recovery, with two rounds of exercise for 31P -MRS and 31P-MRI, respectively. Unpaired t-tests were used to compare 31P-MRS and 31P-MRI results between the HF and control cohorts. The results show that PCr resynthesis rate was significantly slower in the HF cohort compared to the controls using 31P-MRS (P = 0.0003) and 31P-MRI (P = 0.0014). 31P-MRI showed significant differences between the cohorts in muscle groups (soleus (P = 0.0018), gastrocnemius lateral (P = 0.0007) and gastrocnemius medial (P = 0.0054)). The results from this study suggest that 31P-MRS/31P-MRI may be used to quantify lower leg muscle oxidative metabolism in HF patients, with 31P-MRI giving an additional advantage of allowing further localization of oxidative metabolism deficits. Upon further validation, these techniques may serve as a potentially useful clinical imaging biomarker for staging and monitoring therapies in HF-patients.Rajiv G. MenonDing XiaStuart D. KatzRavinder R. RegatteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rajiv G. Menon Ding Xia Stuart D. Katz Ravinder R. Regatte Dynamic 31P-MRI and 31P-MRS of lower leg muscles in heart failure patients
description	Abstract Impaired oxidative metabolism is one of multi-variate factors leading to exercise intolerance in heart failure patients. The purpose of the study was to demonstrate the use of dynamic 31P magnetic resonance spectroscopy (MRS) and 31P magnetic resonance imaging (MRI) techniques to measure PCr resynthesis rate post-exercise as a biomarker for oxidative metabolism in skeletal muscle in HF patients and controls. In this prospective imaging study, we recruited six HF patients and five healthy controls. The imaging protocol included 31P-MRS, spectrally selective 3D turbo spin echo for 31P-MRI, and Dixon multi-echo GRE for fat–water imaging on a 3 T clinical MRI scanner. All the subjects were scanned pre-exercise, during plantar flexion exercise, and post-exercise recovery, with two rounds of exercise for 31P -MRS and 31P-MRI, respectively. Unpaired t-tests were used to compare 31P-MRS and 31P-MRI results between the HF and control cohorts. The results show that PCr resynthesis rate was significantly slower in the HF cohort compared to the controls using 31P-MRS (P = 0.0003) and 31P-MRI (P = 0.0014). 31P-MRI showed significant differences between the cohorts in muscle groups (soleus (P = 0.0018), gastrocnemius lateral (P = 0.0007) and gastrocnemius medial (P = 0.0054)). The results from this study suggest that 31P-MRS/31P-MRI may be used to quantify lower leg muscle oxidative metabolism in HF patients, with 31P-MRI giving an additional advantage of allowing further localization of oxidative metabolism deficits. Upon further validation, these techniques may serve as a potentially useful clinical imaging biomarker for staging and monitoring therapies in HF-patients.
format	article
author	Rajiv G. Menon Ding Xia Stuart D. Katz Ravinder R. Regatte
author_facet	Rajiv G. Menon Ding Xia Stuart D. Katz Ravinder R. Regatte
author_sort	Rajiv G. Menon
title	Dynamic 31P-MRI and 31P-MRS of lower leg muscles in heart failure patients
title_short	Dynamic 31P-MRI and 31P-MRS of lower leg muscles in heart failure patients
title_full	Dynamic 31P-MRI and 31P-MRS of lower leg muscles in heart failure patients
title_fullStr	Dynamic 31P-MRI and 31P-MRS of lower leg muscles in heart failure patients
title_full_unstemmed	Dynamic 31P-MRI and 31P-MRS of lower leg muscles in heart failure patients
title_sort	dynamic 31p-mri and 31p-mrs of lower leg muscles in heart failure patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e98d7af02b548e1a83de243c28ee62b
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Dynamic 31P-MRI and 31P-MRS of lower leg muscles in heart failure patients

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